<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27898

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMPGMLMDTGLGDLFEDNASTIRGIQEYIDRLRQGGCRQSIAWGKLGCIASVAANGTDVEIRHLQASTKDGSWSLSSKHTIKNVHGGSQLASVHWNNIGSEIAITDIYGRLAIWTVYVSLDRLNLLRQSQVTARDDLSMLAGLWWLNMNKPYALSKAAIKTDGVFKYPTNSLPPMGPLNPIQGRAACLGVTRHGVVKMWYSSDAQHIQKATAELESYTSMDDLITHAAYAPDRDRTAVLAVYTQSKQLRLYRISIDWKHPALPPNTNVSQLPLPVTIIVKRLKIEHYPGDGQDSATSFLTHLEVLSPFPGNNMQYHVVLGFFANTSQQQPVTTIKRWELRNIGTSLHPGFDQLAQRRNSTVTEKERHELISYPDVPLHKCALSVTQINASTMIGVTFTDGSFEIRDRMQFNTVHPTANNDKLLNMVHAGWHFPLLGPHVDIVLSPNYAAVALLTKEHDVNLVLMTHNDALEGTPEENPNILIAAATLAQQHACSSNNHSNNDDLAAVARQYNNDHFKTCVLLEAHRSLNQAIDFLQEQSNEKLQRNPFFQRCLSLQSVLYYKGWANPKPIPAKIAQATLHLKATSVGFGYFMNNVARHRQDVEDSKSNALQNLLGVVKWEIDFHVYLVDELLELARRVRSNPGDMELVKKIMHETNSCALPLILTGASRFLLKYNSRALRGFDQAARDHLAQNTVDEALKQGFQSLRTIMDANPVKFNMFEKLLVDIIAHIKRITETWDAQRRIDVDRMIFLTGEIPEVFYPIVEKFLQHSLGILKNDIDPSQIFFFDTTWLGFHDDRKSVVFKRTEKVDTLRKCLLKKGTPVRRCLRCGEVVEDLIPSARMGLWLQNVSRVCVCGCLWMHGD
Length862
PositionTail
OrganismArthrobotrys oligospora (strain ATCC 24927 / CBS 115.81 / DSM 1491) (Nematode-trapping fungus) (Didymozoophaga oligospora)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Orbiliomycetes> Orbiliales> Orbiliaceae> Orbilia> Arthrobotrys oligospora.
Aromaticity0.08
Grand average of hydropathy-0.243
Instability index42.14
Isoelectric point8.25
Molecular weight97118.05
Publications
PubMed=21909256

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27898
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.40|      59|     331|      47|     114|       1
---------------------------------------------------------------------------
   47-  114 (98.71/73.79)	CIASVAangtdveirHLQAST......KDGSWSLSSKHTIKNVHGGSQ....LASVH..WN..NIGS..EIAITDIYGRLAIWT
  379-  453 (79.69/45.65)	CALSVT.........QINASTmigvtfTDGSFEIRDRMQFNTVHPTANndklLNMVHagWHfpLLGPhvDIVLSPNYAAVALLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     137.63|      32|     331|     331|     362|       2
---------------------------------------------------------------------------
  331-  362 (55.65/36.00)	TTIKRWELRNIGTSLHPGFDQLAQRR..NSTVTE
  617-  643 (36.84/21.41)	....KWEI.DFHVYLVDELLELARRV..RSNPGD
  664-  696 (45.14/27.85)	TGASRFLLKYNSRALR.GFDQAARDHlaQNTVDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     216.11|      57|     364|     178|     236|       3
---------------------------------------------------------------------------
  178-  236 (96.86/75.40)	NPIQGRaaCLGVTRHGVVKMWYSSD..AQHIQKATAELESYTS......MDDLITHA.AYAPDRDRTA
  487-  518 (35.78/20.03)	...........................AQ..QHACSS.NNHSN......NDDLAAVArQYNNDHFKTC
  545-  608 (83.47/58.56)	NPFFQR..CLSLQSVLYYKGWANPKpiPAKIAQATLHLKA.TSvgfgyfMNNVARHR.QDVEDSKSNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.56|      23|     698|     125|     149|       4
---------------------------------------------------------------------------
  125-  149 (38.98/29.97)	LRQSQVTarDDL..SMLAGLWWLNMNK
  826-  850 (37.59/22.50)	LRCGEVV..EDLipSARMGLWLQNVSR
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27898 with Med16 domain of Kingdom Fungi
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