<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27894

Description Uncharacterized protein
SequenceMTAAPASPQQIRDRLLQAIDPQSNIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTTNEELAKRAKKLLRSWQKLIEPAHQNEAALRGLAGAAGSANGGAHHCRPEAGPPGTPKSIQELKSRNDIQRLPGQRPDRLGGQKRRGDQRDLGHPGPPAKVSKASHEPLLPNSSPLPTNGISGSPESFPGPPDGGGGGGGGGGGHGPESGRVEPTENDTHSGKIPVHAVRPHTSSPGLGQPPGPCLQTKAAVLQQLDRVDETPGPPHPRGPARCSFSPRNSRHEGSFARQRSPYAPKGSVSSPSPRLQPLDATQVPSPLPLAQPSTPPVRRLELLPSAESPVRWLEQPEGRHRLAAPGCKAGLPPAGFSPDSSRVDSDAAAAGGSDSKKKKRYRPRDYTVNLDGQVAEAGVRPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPARTEQPPRTEPDAPEAKASLQSPFEQTNWKELSGNEIIQSYLSRQSSLLLSSGTQTPGAHHFMSKYLKQEQSRLGARRPHVLLPHSPPAELPGLSRELTQDDLDRIQAGQWPGVNGCRDTQGNWYDWTQCISLDPHGDDGRLNVLPYVCLD
Length599
PositionUnknown
OrganismOryctolagus cuniculus (Rabbit)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Lagomorpha> Leporidae> Oryctolagus.
Aromaticity0.04
Grand average of hydropathy-0.849
Instability index64.29
Isoelectric point9.52
Molecular weight64647.78
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27894
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      86.23|      19|      19|     172|     190|       2
---------------------------------------------------------------------------
  151-  166 (25.46/ 6.31)	GDQR..DL...GHPGPPAKVS
  168-  186 (30.89/ 9.37)	ASHE..PLLPNSSPLPTNGIS
  187-  207 (29.87/ 8.80)	GSPEsfPGPPDGGGGGGGGGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.64|      16|      18|      87|     102|       3
---------------------------------------------------------------------------
   87-  102 (26.13/ 9.96)	AHQNEAALRGLAGAAG
  104-  119 (31.51/13.38)	ANGGAHHCRPEAGPPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.19|      24|      24|     305|     328|       5
---------------------------------------------------------------------------
  251-  272 (26.29/ 7.34)	QTKAAVLQQLDrVD..ETPGP..P..HP
  278-  304 (24.02/ 6.05)	CSFSPRNSRHE.GSfaRQRSPYaPKGSV
  305-  328 (43.89/17.34)	SSPSPRLQPLD.AT..QVPSPL.PLAQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.53|      23|      24|     374|     396|       6
---------------------------------------------------------------------------
  374-  396 (38.29/25.49)	PDSSRV..DSDAAAAGGSDSKKKKR
  399-  423 (35.24/22.82)	PRDYTVnlDGQVAEAGVRPVRLKER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.32|      14|      15|     216|     229|       7
---------------------------------------------------------------------------
  216-  229 (21.32/ 6.74)	VEPTENDTHSGKIP
  233-  246 (29.00/11.81)	VRPHTSSPGLGQPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.04|      14|     100|     343|     367|       8
---------------------------------------------------------------------------
  354-  367 (26.70/ 6.58)	GRHRLAAPGCKAGL
  455-  468 (25.34/11.55)	PRTEPDAPEAKASL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.07|      18|      19|      44|      62|       9
---------------------------------------------------------------------------
   44-   62 (23.52/19.19)	TKEALEEtRLGKLINDVRK
   65-   82 (29.55/19.14)	TNEELAK.RAKKLLRSWQK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27894 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AHQNEAALRGLAGAAGSANGGAHHCRPEAGPPGTPKSIQELKSRNDIQRLPGQRPDRLGGQKRRGDQRDLGHPGPPAKVSKASHEPLLPNSSPLPTNGISGSPESFPGPPDGGGGGGGGGGGHGPESGRVEPTENDTHSGKIPVHAVRPHTSSPGLGQPPGPCLQTKAAVLQQLDRVDETPGPPHPRGPARCSFSPRNSRHEGSFARQRSPYAPKGSVSSPSPRLQPLDATQVPSPLPLAQPSTPPVRRLELLPSAESPVRWLEQPEGRHRLAAPGCKAGLPPAGFSPDSSRVDSDAAAAGGSDSKKKKRYRPRDYTVNLDGQVAEAGVRPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPARTEQPPRTEPDAPEAKASLQSPFEQTNW
2) RLGARRPHVLLPHSPPAELPGLSRELTQDDLDRIQAGQWP
87
521
477
560










Molecular Recognition Features






MoRF SequenceStartStop




1) IRDRLL
2) KKKKRYRPRDYTVNLD
3) VRRLELLP
11
392
333
16
407
340