<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27893

Description Mediator complex subunit 25
SequenceRFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTDSLVQKIGEQGIHFSVVSPRKLPALRLLFEKAAPPSLLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVPLPPAPSSGAALAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGAPFSQAAAPPSGPPGAPKPPPASQPSLVSTVAPGAGLAPSAQPGAPSMAGTVAPGGVSGPSPAQLGTPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGTAGQPQPQGTSQTPPGAPQGPPGAAPGPAPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPTLLPPPHQGLGQPQLGPPLLHPPPTQSWPAQLPPRAPLPGQMLLSGGPRGPVPPPGLQPSVMEDDILMDLI
Length642
PositionUnknown
OrganismOryctolagus cuniculus (Rabbit)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Lagomorpha> Leporidae> Oryctolagus.
Aromaticity0.04
Grand average of hydropathy-0.283
Instability index61.41
Isoelectric point9.54
Molecular weight66890.30
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27893
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     530.58|      65|      65|     451|     515|       2
---------------------------------------------------------------------------
   92-  154 (62.43/12.13)	LLFEK...AAPPSLLEPL..QPPADV.....SQDprhmvlvrglvlPVGGG..................SAPGPLQ..............PKQPVPLPPA..........................PSS.GA
  155-  199 (58.30/10.69)	AL......AAPQQPLPPV...PPQYQ.....VPG............NLSAA..................QVAAQNA..............VEAAK...........................nQKA..GLGP
  200-  240 (51.15/ 8.22)	................RF..SPINPL.....QQ...............AAS..................G.VGAPF..............SQAAA...P..PSG.........pP.....GA.PKPPPASQP
  241-  290 (64.30/12.78)	SLVST...VAPGAGL......APSAQ.....P................GAP..................SMAGTVA..............PGGVSGPSP.AQLG......TPA.L.....GG.QQS......
  360-  423 (66.52/13.54)	LF.......RNSR.MVQF..HFTNKD.....LES............LKGLY..................RIMGNGF..............A.GCVHFPHTAPCE......VRV.LmllysSK.KKIFMGLIP
  424-  465 (47.90/ 7.09)	Y..DQ...SGFVNGIRQVitNHKQVQ.....QQK.........................................................................leqQRG.M.....GA.QQAPPGLGP
  466-  528 (117.40/31.19)	ILEDQ...ARPSQNLLQL..RPPQPQ.....PQG............TVGAS..................GTAGQPQ..............PQGTSQTPPGAPQG......PPG.A.....AP.GPAPPG..P
  529-  630 (62.58/12.18)	ILRPQnpgANPQLRSLLL..NPPPPQtgvppPQ................ASlhhlqppgaptllppphqGL.GQPQlgppllhppptqswP...AQLPPRAPLPgqmllsGGP.R.....GP..VPPPGLQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.71|      15|      23|     318|     332|       3
---------------------------------------------------------------------------
  318-  332 (28.29/22.23)	KLTRSL.PCQVYVNHG
  343-  358 (21.42/14.48)	KLIMQLiPQQLLTTLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27893 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVPLPPAPSSGAALAAPQQPLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAASGVGAPFSQAAAPPSGPPGAPKPPPASQPSLVSTVAPGAGLAPSAQPGAPSMAGTVAPGGVSGPSPAQLGTPALG
2) HKQVQQQKLEQQRGMGAQQAPPGLGPILEDQARPSQNLLQLRPPQPQPQGTVGASGTAGQPQPQGTSQTPPGAPQGPPGAAPGPAPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPTLLPPPHQGLGQPQLGPPLLHPPPTQSWPAQLPPRAPLPGQMLLSGGPRGPVPPPGLQPSVMEDDILMD
131
440
286
640










Molecular Recognition Features






MoRF SequenceStartStop




NANANA