<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27892

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMKAQGKTEGESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPVSCPELVQQLREKNFDEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAIMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNMKYYASPSDLLDDKTASPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSVTSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETQPTYAPLYELITQFELSKDPDPVPLSHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNIIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLPPDKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDSDVFQTNNNENPYTDPADLIADAAGSPSSDSPTNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFASQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIISVAGKALGPADLMEHHSGSQSPLLATGDLGKEKTQKRVKEGNGTSNSSLPGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSSSASTSGKMKSSKSEGSSSSKLSSSMYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSSTKMKPQGKPSSLMNPSLSKPNISPSHSRPPGSSDKLSSPMKPVPGTPPSKAKSPISSGSGGSHISGTSSSSGMKSSSGLGSSGSLSQKTPPSSNSCTASSASFSSSGSSMSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGSEDPMDGQMGVSTNSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSTEKHKKHKKDKKKVKDKDRDRERDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSADRPSRLSPDFMIGEEDDDLMDVALIGN
Length1581
PositionMiddle
OrganismOryctolagus cuniculus (Rabbit)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Lagomorpha> Leporidae> Oryctolagus.
Aromaticity0.04
Grand average of hydropathy-0.682
Instability index54.64
Isoelectric point8.94
Molecular weight168369.15
Publications
PubMed=21993624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	ISS:UniProtKB
nucleolus	GO:0005730	ISS:UniProtKB
nucleoplasm	GO:0005654	IEA:Ensembl
nucleus	GO:0005634	ISS:UniProtKB

GO - Biological Function
chromatin binding	GO:0003682	ISS:UniProtKB
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	ISS:UniProtKB
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	ISS:UniProtKB
transcription coactivator activity	GO:0003713	ISS:UniProtKB
transcription coregulator activity	GO:0003712	ISS:UniProtKB
transcription corepressor activity	GO:0003714	ISS:UniProtKB
vitamin D receptor binding	GO:0042809	IEA:Ensembl

GO - Biological Process
androgen biosynthetic process	GO:0006702	ISS:UniProtKB
angiogenesis	GO:0001525	ISS:UniProtKB
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	ISS:UniProtKB
cellular response to epidermal growth factor stimulus	GO:0071364	ISS:UniProtKB
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
embryonic placenta development	GO:0001892	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
epithelial cell proliferation involved in mammary gland duct elongation	GO:0060750	IEA:Ensembl
erythrocyte development	GO:0048821	ISS:UniProtKB
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	ISS:UniProtKB
keratinocyte differentiation	GO:0030216	ISS:UniProtKB
lactation	GO:0007595	IEA:Ensembl
lens development in camera-type eye	GO:0002088	ISS:UniProtKB
liver development	GO:0001889	IEA:Ensembl
mammary gland branching involved in pregnancy	GO:0060745	IEA:Ensembl
mammary gland branching involved in thelarche	GO:0060744	IEA:Ensembl
megakaryocyte development	GO:0035855	ISS:UniProtKB
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	ISS:UniProtKB
negative regulation of apoptotic process	GO:0043066	ISS:UniProtKB
negative regulation of keratinocyte proliferation	GO:0010839	ISS:UniProtKB
negative regulation of neuron differentiation	GO:0045665	ISS:UniProtKB
negative regulation of transcription by RNA polymerase II	GO:0000122	ISS:UniProtKB
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	ISS:UniProtKB
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	ISS:UniProtKB
positive regulation of transcription by RNA polymerase II	GO:0045944	ISS:UniProtKB
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	ISS:UniProtKB
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of RNA biosynthetic process	GO:2001141	ISS:UniProtKB
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	ISS:UniProtKB
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27892
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     863.33|     100|     100|    1109|    1208|       1
---------------------------------------------------------------------------
  589-  665 (81.40/16.35)	...............SVGHGEDFSKV..........SQNPILTSLLQ..IT..G..NG..........GSTI..................G..SSP...............TPPHHT.PPPVSS.M........AG....N................TK.....N...HP.MLMN..L.L......K.DNP.AQD.FS.TLY.G...SS...
  671-  784 (77.01/15.06)	.....NSSSG................SP...RM.EMCSGSNKTKKKK..SS..R..LP..........PDKPkhqteddfqrelfsmdvdS..QNPifdvnmtadtldtphITP.AP.SQCSTP.P........TT....Y................PQ.....P...VPHP..QPSI.Q......RmVRL.SSS.DS.IGP.D...VTDIL
  786-  871 (69.34/12.79)	D...IAEEASKLP.STSDD...CPPIGT...PV.RDS.SSSGHSQSAlfDS..DvfQT..........NN................................................................NE....N................PY.....T...DPADLIADAA.G......S.PSSdSPTnHF.FPD.GvdfNPDLL
  885- 1005 (81.49/16.38)	D...ESSQSGDND.DFK..GFASQALNTlgvPM.LG..GDNGETKFK..GN..S..QAdtvdfsiisvAGKA.................lG..PAD...............LMEH...HSGSQS.PllatgdlgKE....K................TQkrvkeGngtSNSSLPGPGLdS......K.P....GK.RS.RTP.....SNDGK
 1008- 1093 (91.25/19.27)	D...K...PPKRK.KADTEGKSPSHSSS...NRpFTPPTSTGGSKSP..GS..S.gRS..........QTPP..................GvaTPP...............IPKITI.QI.PKG.T........VM......................V.....G...KPSS.....................HS.QY.TSS.G...SVSSS
 1109- 1208 (179.80/45.43)	S...SASTSGKMK.SSKSEGSSSSKLSS...SM.YSSQGSSGSSQSK..NS..S..QS..........GGKP..................G..SSP...............ITKHGL.SSGSSS.T........KM....K................PQ.....G...KPSSLMNPSL.S......K.PNI.SPS.HS.RPP.G...SSDKL
 1210- 1263 (49.62/ 6.96)	.........SPMK.P..VPGTPPSKAKS...PI...SSGSGGSHISG..TS..S..SS..........GMK...................S..SS....................GLgSSGSLS.Q........KT....P................P......................................................
 1264- 1324 (61.67/10.52)	..............SSNSCTASSAS.........FSSSGSSMSSQN...................................................................QHGS.SKGKS..............................................PSRNKKPSL.TavidklK.HGV.VTS.....GP.G...SED..
 1325- 1431 (85.95/17.70)	......PMDGQMGvSTNSSHPMSSKHNM...SG.GEFQGKREKSDKD..KSkvS..TS..........GGSV..................D..SSK...............KTSESK.NVGSTGvA........KIiiskH................DG.....G...SPSIKAKVTL.Q......K.PGE.SSG.EGlRPQmA...SSKNY
 1433- 1543 (85.80/17.65)	SpliSGSTPKHER.GSPSH.SKSPAYTP...QN.LDSESESGSSIAE..KS..Y..QN........spSSDD..................G..IRP...............LPEYST.EKHKKH.K........KD....KkkvkdkdrdrerdkdrDK.....K...KSHSIKPESW.S......K.SPI.SSD.QS..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     201.93|      47|      47|     311|     357|       2
---------------------------------------------------------------------------
  274-  329 (55.09/28.55)	LiMGSHPVdnkWTPSFSSVT....SANSVDLP...acfflkfpqPIPVS..............R...AFVQK.LQNC..........TGIP
  330-  382 (57.03/29.84)	L.FETQPT...YAPLYELITQFELSKDPDPVP...lshnmrfyaALPGQ.........................QHC......yflnKDAP
  383-  439 (46.55/22.87)	L.PDGRSL...QGTLVSKITFQH....PGRVP...........lILNII..............RhqvAYNTL.IGSCvkrtilkedsPGLL
  440-  506 (43.25/20.68)	Q.FEV.......CPLSE..SRFSVSFQ.HPVNdslvcvvmdvqdSTHVScklykglsdalictD...DFIAKvVQRC..........MSIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.86|      16|      37|     198|     218|       4
---------------------------------------------------------------------------
  198-  218 (21.26/23.14)	AGPLdkILHGSVgylTPRSGG
  238-  253 (30.60/15.34)	ASPI..ILHENN...VPRSLG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27892 with Med1 domain of Kingdom Metazoa
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