<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27889

Description Mediator of RNA polymerase II transcription subunit 15
SequenceEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAAPQITQVDVQEEKRTWKIQEQGQETWKGHPFAIQGINGRRKRDQKREGIFQTSWKNWNKKKKRAITQQKSKKQSQSHKKEEKKHKKKKKRDLSQLQLQQAALIKLHHQNQQQVPGAPPPSWAQAGEQGPVTAPSQVLPLNHPGDVSSRAQSPSVAGALLPTLQAQPPMQQPPMLVSQAQALPGQMLYAQQQLKFVRAPMVVQQPQVQPQVPQVQPQVPQQTAVQTAQAAQMVAPGVQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPSSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCARKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWVDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAT
Length725
PositionTail
OrganismOryctolagus cuniculus (Rabbit)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Lagomorpha> Leporidae> Oryctolagus.
Aromaticity0.04
Grand average of hydropathy-0.630
Instability index75.55
Isoelectric point9.80
Molecular weight79073.67
Publications
PubMed=21993624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27889
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     138.03|      25|      26|     256|     280|       2
---------------------------------------------------------------------------
   73-   91 (30.77/ 7.31)	AA...GIGMPPRGPG......QSLGGMG
  256-  280 (44.27/13.78)	AP...SQVLPLNHPGDVSSRAQSPSVAG
  283-  307 (32.58/ 8.18)	LPtlqAQP.PMQQPPMLVSQAQ..ALPG
  441-  460 (30.42/ 7.14)	.P...SPG.PLNTPVNPSS.VMSP..AG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.38|      19|      27|     145|     170|       3
---------------------------------------------------------------------------
  139-  166 (25.74/26.74)	TWKiqEQG..QETWKghpfaiqGINGRRKR
  167-  187 (32.64/16.52)	DQK..REGifQTSWK.......NWNKKKKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.40|      23|      28|     500|     526|       4
---------------------------------------------------------------------------
  491-  518 (35.23/18.41)	DKNEdrkkdLSKMKSLLDILTDPSKRCP
  523-  547 (39.17/13.81)	QKCE...iaLEKLKNDMAVPTPPPPPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.25|      15|      20|     322|     341|       5
---------------------------------------------------------------------------
  233-  247 (29.23/ 8.51)	NQQQVPGAPPPS.......WAQ
  330-  351 (21.02/ 8.64)	VQPQVPQVQPQVpqqtavqTAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.84|      34|     158|     395|     438|       6
---------------------------------------------------------------------------
   97-  133 (60.04/19.02)	GQPmplSGQPPPG.TSGMAPHGMAVVSTAAPQITQVDV
  396-  430 (61.81/32.44)	GQP...SSQPSSNvSSGPAPSPSSFLPSPSPQPSQSPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27889 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APMVVQQPQVQPQVPQVQPQVPQQTAVQTAQAAQMVAPGVQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPSSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
2) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSTAAPQITQVDVQEEKRTWKIQEQGQETWKGHPFAIQGINGRRKRDQKREGIFQTSWKNWNKKKKRAITQQKSKKQSQSHKKEEKKHKKKKKRDLSQLQLQQAA
3) IKLHHQNQQQVPGAPPPSWAQAGEQGPVTAPSQVLPLNHPGDVSSRAQSPSVAGALLPTLQAQPPMQQPPMLVSQAQALP
321
47
227
475
225
306










Molecular Recognition Features






MoRF SequenceStartStop




NANANA