<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27883

Description Cyclin dependent kinase 19
SequenceMDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQVPPPQQNSTQTNGTAGGAAAGVGGAGAGLQHSQDSSLSQVPPSKKPRLGPSGANSGGPGLPADYQHSSSRLNYQSNVQGSSQAQSTLGYSSSSQQSAQYHPSHQAHRY
Length502
PositionKinase
OrganismOryctolagus cuniculus (Rabbit)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Lagomorpha> Leporidae> Oryctolagus.
Aromaticity0.09
Grand average of hydropathy-0.677
Instability index51.43
Isoelectric point8.66
Molecular weight56692.49
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27883
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.76|      28|      36|     394|     426|       1
---------------------------------------------------------------------------
  394-  425 (43.41/28.58)	QVPPPQQNSTqtnGTAgGAAAGVGGAGAGLQH
  433-  460 (52.35/23.57)	QVPPSKKPRL...GPS.GANSGGPGLPADYQH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.89|      15|      41|     151|     165|       2
---------------------------------------------------------------------------
  151-  165 (25.86/14.56)	DLKPANILVMGEGPE
  189-  203 (27.03/15.50)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.33|      28|      41|     314|     341|       3
---------------------------------------------------------------------------
  314-  341 (48.64/29.71)	KLLTMD.PTKRITSEQALQDPYFQEDPLP
  357-  385 (45.69/27.47)	EFLNEDePEEKGDKNQQQQQNQHQQPTAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.50|      23|      25|      17|      41|       4
---------------------------------------------------------------------------
   17-   41 (33.05/28.54)	EDLFEYEGCKVgRGTyGHVYKARRK
   44-   66 (40.46/23.93)	KDEKEYALKQI.EGT.GISMSACRE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27883 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQVPPPQQNSTQTNGTAGGAAAGVGGAGAGLQHSQDSSLSQVPPSKKPRLGPSGANSGGPGLPADYQHSSSRLNYQSNVQGSSQAQSTLGYSSSSQQSAQYHPSHQAHRY
353
502










Molecular Recognition Features






MoRF SequenceStartStop




1) SKKPRLG
437
443