<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27872

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKPQVNQKDNFWLVTPRSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKDEVFGYLAKYTVPVMRAAWLIKMTCAYYAAITETKVKKRLVIDPFMEWTQIITRYLWEQLQKMAEYYRPGPTGSGSCGSTVGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVIAAQSTSTLPTTPAPQPPTSSTPSTPFSDLLLCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFPLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGAEELPEEEGGGGNGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSAASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYNQVHQIVKNWRDGQYLDDCKPKQLMHEALKLRLNLMESMFDTVQRSTQQTTECAILLLEIIISSTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKELGEHQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPNTEERKKKATKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSIPHLNYRPGPIGLYTQNQPLPAGGPRVDTYRPVRLPMQKLPTRPTYPGVLPTTMTNVISLDPSYKTSMYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTTYVSHVGLQQHTGPADPARHLQQRSSGYVHQQAPTYGHGLASAQRFPHPTLQQTTMLGTMNPLSTQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQPQPPQQQQQQPPPPQQHQQQPQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2160
PositionKinase
OrganismOryctolagus cuniculus (Rabbit)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Lagomorpha> Leporidae> Oryctolagus.
Aromaticity0.07
Grand average of hydropathy-0.506
Instability index57.57
Isoelectric point6.66
Molecular weight241237.94
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27872
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     186.94|      15|      16|    2025|    2039|       1
---------------------------------------------------------------------------
 2025- 2039 (33.76/13.41)	EQQQQQQQQ..QQQQ..QQ
 2042- 2056 (35.61/14.58)	QQQQQQQQQ..QQQQ..QQ
 2061- 2075 (30.17/11.14)	QQQQQQILR..QQQQ..QQ
 2076- 2092 (32.35/12.52)	QQQQQQQPQppQQQQ..QQ
 2096- 2110 (29.04/10.43)	PQQHQQQPQ..QQAA..PP
 2111- 2127 (26.01/ 8.51)	QPQPQSQPQ..FQRQglQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     710.16|     212|     234|     354|     585|       2
---------------------------------------------------------------------------
  217-  441 (246.33/160.07)	.........GSTVGPLPHDVEV....AIRQWDYNEKLamfmfqDGMLDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRRLAYFCT.RRLAlQL..DGVSSHSShvIAAQSTSTlPTTPAPQ..................PPtsstpstpfsdlllcpqHRPLVFGLscilqtILLCCP...SALVWH..YSLT.DSR..IKTGSPLDHlPIAPSNLPM..PEGNSAfTQQVRAKLReiEQQIKErGQAVEVRWS
  442-  674 (322.51/188.81)	FDKCQEatAGFTIGRVLHTLEVLDSHSFERSDFSNSL......DSLCNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKRQAEIEA.ERCG.ES..EAADEKGS..IASGSLSA.PSAPIFQDVLLQFL...DTQapmltDP.............rsesERVEFFNL......VLLFCElirHDVFSHnmYTCTlISRgdLAFGAPGPR.PPSPFDDPAddPERKEA.EGSSSSKLE..DPGLSE.SMDIDPSSS
  677-  814 (141.32/68.04)	FEDMEK..PDFPLFSPTMPCEGKGSPSPEKPDVEKEV.....kPPPKEKIEGtLG........VLYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRDDARHAiKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ........................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.68|      34|     231|    1899|    1937|       4
---------------------------------------------------------------------------
 1899- 1937 (60.20/36.99)	RQQQPAVPQG....QRLRQQLQQSQGMLGqssvhQMTPSSSYG
 1975- 2012 (58.48/27.66)	HQQAPTYGHGlasaQRFPHPTLQQTTMLG.....TMNPLSTQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.04|      42|      44|     934|     976|       5
---------------------------------------------------------------------------
  926-  970 (66.82/46.79)	CIVAVL.rhYHACLILnQDQMAQVFEGLCGVVKHGM..NRSDGSSAER
  971- 1017 (66.22/41.65)	CILAYLydlYTSCSHL.KSKFGELFSDFCSKVKNTIycNVEPSESNMR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     312.53|      76|     231|    1143|    1219|       6
---------------------------------------------------------------------------
 1143- 1219 (123.94/74.87)	LLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRiLLHLFKT.PQLNPCQSDG...NKPTVG.IRSSCDRHLLAASQNRIVDG
 1296- 1360 (97.82/54.28)	......RC..LKSLCEDSNDLQDPVLSSAQAQR.LMQLICY.PHRLLDNEDG...ENPQ....RQRIKRILQNLDQWTMRQS
 1379- 1455 (90.77/49.78)	LLENIAK.ATIEVFQQSA..ETGSSSGSAASN..MPSSSKTkPVLSSLERSGvwlVAPLIAkLPTSVQGHVLKAAGEELEKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.40|      17|      17|    1780|    1796|      10
---------------------------------------------------------------------------
 1759- 1773 (22.48/12.31)	..EPEKKAPEPPKTDKP
 1780- 1796 (29.60/19.27)	TEERKKKATKGKKRSQP
 1800- 1812 (25.32/15.08)	TEDY....GMGPGRSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.10|      18|     174|    1952|    1971|      11
---------------------------------------------------------------------------
 1952- 1971 (30.03/24.49)	GL.....QQHTgpADPARHLQQRSS
 2124- 2146 (26.07/13.07)	GLqqtqqQQQT..AALVRQLQQQLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.70|      15|      23|    1553|    1575|      12
---------------------------------------------------------------------------
 1547- 1561 (23.90/ 6.74)	TVQRSTQQTTECAIL
 1570- 1584 (24.80/24.12)	TVDMQSNNELFTTVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     152.70|      36|     127|    1491|    1527|      13
---------------------------------------------------------------------------
 1491- 1527 (58.97/36.31)	KGQDE..QREGLLTSLyNQVHQIVKNWRDGQYLDDCKPK
 1620- 1655 (56.12/29.77)	KLQKE..LGEHQSDSL.EKVRQLLPLPKQTRDVITCEPQ
 1667- 1697 (37.62/17.48)	AGFDSifKKEGLQVS....TKQKISPW...DLFEGLKP.
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27872 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPNTEERKKKATKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHANPGSIPHLNYRPGPIGLYTQNQPLPAGGPRVDTYRPVRLPMQKLPTRPTYPGVLPTTMTNV
2) GAPGPRPPSPFDDPADDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVL
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKN
4) LDPSYKTSMYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQ
5) LFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLY
6) QQQQQQQQQQQPQPPQQQQQQPPPPQQHQQQPQQQAAPPQPQPQSQPQFQRQGLQQT
7) YVSHVGLQQHTGPADPARHLQQRSSGYVHQQAPTYGHGLASAQRFPHPTLQQTTMLGTMNPLSTQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ
1737
628
15
1889
687
2072
1947
1886
676
61
1942
727
2128
2056










Molecular Recognition Features






MoRF SequenceStartStop




1) EERKKKATK
2) IFGRY
3) MAAFG
1781
2156
1
1789
2160
5