<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27870

Description Mediator complex subunit 12 like
SequenceFGLLSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTGRSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKMKKRQVPDPNLEWTQISTRYLREQLAKISDFYHVASSAGDGPVPVPPEVEQAMRQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPTLLAAHSPHMMIGPNSSSIGAPSPGPPGPGMSPVHLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENADEHYSKDHDVKMEIFSPMPGESCENANPSLGRRMSVNSEKLVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGGGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQAYFFPQSAGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVSSLKNEDFTMRGLRRDGNADDIWTASQNSKACGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVAEMNNLLDNIAKATIEVFQQSADLNNSASNSGLSLFNPNSIGSADASSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIRARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLTKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQARGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQSLPAGGSRLDPAGSFVPSNTKQALSHMLQRRSGAMMQPPALHTITSQQQLIQMKLLQQQQQQRLLRQAQTRPFQQVGADPVFQGQPGDQAALFAAQARPSLQLPQYPGLQQAQTMPQGYTMYGTQMSLQQTAQQQAGSVVLSPSYNSRAYPAAHSSPALMERLRQIQQQPTSYVQQQTSPYLQPFPGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQVLGGEPPQPQQPPQPPQSSQPQSQPLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
Length2153
PositionKinase
OrganismOryctolagus cuniculus (Rabbit)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Lagomorpha> Leporidae> Oryctolagus.
Aromaticity0.07
Grand average of hydropathy-0.419
Instability index59.03
Isoelectric point7.84
Molecular weight240650.32
Publications
PubMed=21993624

Function

Annotated function 
ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744
	.uniprot.org/unirule/RU364152' style='color:#FF0000;'>RuleBase:RU364152
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats
>MDP27870
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     115.24|      21|      25|    1841|    1861|       1
---------------------------------------------------------------------------
 1897- 1917 (30.63/10.97)	QAQTRPFQQVGAD..PVFQGQPG
 1995- 2017 (31.98/11.81)	QIQQQPTSYVQQQtsPYLQPFPG
 2079- 2094 (23.97/ 6.84)	...PQPQQP.PQP..PQ.SSQPQ
 2095- 2114 (28.65/ 9.74)	SQPLGLQAMQPQQ..P.LFPRQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.38|      29|      38|    1244|    1280|       2
---------------------------------------------------------------------------
 1244- 1277 (33.73/33.15)	LRTICQQEWVGEhClKEPERLctDKELIlDPVLS
 1285- 1313 (49.65/28.53)	LQLICYPHGIKE.C.TEGDNL..QRQHI.KRILQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.22|      34|     152|     872|     918|       4
---------------------------------------------------------------------------
  879-  913 (56.61/61.42)	CIVAVLRR.YHSCLILNpEQTAQVFEGLCGVVKHVV
  924-  958 (57.61/26.80)	CILAYLYDlYVSCSHLR.SKFGDLFSSACSKVKQTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.08|      12|     152|    1708|    1720|      13
---------------------------------------------------------------------------
    3-   14 (22.27/ 7.94)	LLSYEQRPLKRP
 1709- 1720 (24.81/10.24)	LLLYHTHPMPKP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     148.40|      45|     175|    1852|    1896|      17
---------------------------------------------------------------------------
 1808- 1860 (28.49/ 9.82)	...................QSTLWGYNLVGQPQQPGFFlqnqslpaggsrldpagsfvpsntK.......................QALSHMLQR
 1861- 1928 (61.03/30.21)	RSGAMMQ.P..PALHTITSQQQLIQMKLLQQQQQQRLL........................RqaqtrpfqqvgadpvfqgqpgdqAALFAAQAR
 1929- 1951 (27.77/ 9.37)	PSLQLPQ.Y..PGLQQAQTMPQGYTM.....................................................................
 2048- 2078 (31.12/11.47)	PSVPLPQdPmrPRQPQVRQQQRLLQV.LGGEP...............................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.67|      39|     608|     444|     489|      19
---------------------------------------------------------------------------
  444-  489 (61.32/64.21)	CQESTAGVTISRVLHTLEVLDRHCFDrtdssnSMETlYHKIFWANQ
 1054- 1092 (71.35/52.94)	CCSSNHVWGFNDVLCTVDVSDLSFHD......SLAT.FIAILIARQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.32|      22|      38|    1605|    1629|      21
---------------------------------------------------------------------------
 1605- 1629 (30.20/31.28)	TKelGDKRS..ESIDKvRQLLPLPKQT
 1644- 1667 (33.12/21.45)	TK..GNKIAgfDSIDK.KQARGLQVST
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27870 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQQQAGSVVLSPSYNSRAYPAAHSSPALMERLRQIQQQPTSYVQQQTSPYLQPFPGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVPLPQDPMRPRQPQVRQQQRLLQVLGGEPPQPQQPPQPPQSSQPQSQPLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHPSHF
2) PGFFLQNQSLPAGGSRLDPAGSFVPSNTKQALSHMLQRRSGAMMQPPALHT
3) RSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTATDEEKKTKGRKRKTKSSSRVDEYPQSNIYRVPPNYSPISSQMMH
1962
1823
1721
2153
1873
1805










Molecular Recognition Features






MoRF SequenceStartStop




1) YLEPL
1724
1728