<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27865

Description Mediator complex subunit 23
SequenceMVPVARKNVVSTLAPGRQGSRSISLRHQLAPGCAKSFSAGCSPWAPIFFPVCKRVSPGPGALPPGGGGLLPKTPAADLGSSLLLRALLSSGRVAYKRNRRVRSLVSGGVRKRRAPSLFRLPCRSLLFARLWRVPGPLSTGVGKRRGRAAVSSWGLRPSAPFFPQLGPGHPGEAGAMVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLTSCLGAFRQFWSGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRLVCESLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAKEVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQTLNIAQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSKLQIPIPHSLRLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVPQTNLNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMSNENEIITHFPVQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEVHLRQRAFLKRKLVHAIIGSLKDNRPQGWCLSDTYLKCAMNAREENPWIPEDSYYCRLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGEDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVSVINSRSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLLPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAAVPPQAMNSGSPAPQSNQVPVSLPVTQ
Length1552
PositionTail
OrganismOryctolagus cuniculus (Rabbit)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Lagomorpha> Leporidae> Oryctolagus.
Aromaticity0.09
Grand average of hydropathy-0.011
Instability index50.09
Isoelectric point8.83
Molecular weight175778.74
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27865
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     224.70|      56|     133|    1089|    1147|       1
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 1089- 1147 (98.92/71.00)	K.ENSPEHWLQNDWHTK.HMNYHKK...YPEKLYFE.GLAEQVDPPVQIQSPYlPiyFGNVCLRF
 1180- 1214 (31.27/12.86)	KfHDRPVTYLYNTLH...YYEVHLR.....QRAFLKrKLVHAI......................
 1219- 1278 (94.52/57.83)	K.DNRPQGWCLSDTYLKcAMNAREEnpwIPEDSYYC.RLIGRLVDTMAGKSPG.P..FPNCDWRF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     241.52|      58|     133|      16|      89|       2
---------------------------------------------------------------------------
   16-   77 (100.81/60.61)	GRQGSRSISLR......H.QLA...PGCAKSFSAGCSPWAPIFFPVCKRVSPGPGALPpgggGLLPKTPAAD
  146-  211 (82.44/39.33)	GRAAVSSWGLRpsapffP.QLGpghPGEAGAMVQMETQLQSIFEEVVK.TEIIEEAFP....GMFMDTPEDE
  223-  271 (58.27/34.15)	.RQFWSGLSQE.....sHeQCI...QWIVKFIHGQHSPKRISFLYDCLAMAVETGLLP..............
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     445.89|     106|     264|     702|     808|       3
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  702-  808 (169.79/130.13)	GSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESL.G...IKGFISQLLPTV..FKSHAWGiLHTL......LEMFSYRMHHIQP.HYRVQLL
  832-  940 (132.44/95.76)	TALRLITA..LGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIqG.....TWCKDILQTImsFTPHNWA.SHTLscfpgpLQAF.FKQNNVPQ.ESRFNL.
  968- 1073 (143.66/104.65)	GS.PPLFLCLLWKMLLETDH..INQIGYRVLERIGARALV....AHVRTFADFLVYEFSTSA.GgqqLNKCIEILNDMV..WKYNIVT.LDRL...ilcLAMRSHEGNEAQVcYFIIQLL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.95|      19|      30|      95|     113|       4
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   95-  113 (34.09/20.51)	YKRNRRVRSLVSGGVRKRR
  127-  145 (36.86/22.79)	FARLWRVPGPLSTGVGKRR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     289.77|      79|     216|     349|     431|       5
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  349-  393 (61.33/33.82)	.................................................................................................LE.............RNACLLPAY.FAVTEI.RKLYPEGK.LPHWLLGNLVSD..FVDTFRPT
  394-  427 (37.74/24.04)	ARINSICGRCSLLPVVNN..SG.....AICNSWKLDPATLR.......................................................................................................................
  484-  531 (39.35/18.34)	.........................................fplkgllpydkdlfepqtallryvleqpysrdmvcnmlglnkqtlniaqhkqrcpvLE.............DQLVDLVVYaMERSET.EEKFDDGG.TSQLLWQHLSSQliFFVLFQFA
  545-  604 (69.01/40.36)	AGRGLIKGRDHLMWVLLQfiSG.....SI..................................................................................qKNA..LADF.LPVMKLfDLLYPEKEcIP.......VPD...INKPQST
  605-  686 (82.34/49.75)	HAFAMTCIWIHLNRKAQN..DNsklqiPIPHSLRLHHEFLQ..........................................................qslrnkslqmndyKIALLCNAY.STNSEC.FTL.PMGA.LVETIYGN..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.46|      22|     862|     446|     467|       8
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  446-  467 (41.84/27.07)	ALLRYVLE.QP.YSRDMVC...NMLGL
 1309- 1335 (24.62/12.81)	ALLNVVLKsQPlVPRENITawmNAIGL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27865 with Med23 domain of Kingdom Metazoa
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