<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27835

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSTLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGMMGIVRTCRSEIFKKWNSFLCPRPYLNPPSLSFGLQISSDDDAVVSIAIVLGRHRDMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSLFCPISLFLDEKLMGLRFCGARFFLRAFVLFPRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQQQAAPPQPQPQSQPQVAAGLQPQAQGQLPRLDTQPQPSTNIFGRY
Length2106
PositionKinase
OrganismNomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hylobatidae> Nomascus.
Aromaticity0.07
Grand average of hydropathy-0.473
Instability index57.89
Isoelectric point7.15
Molecular weight235090.73
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27835
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     165.07|      16|      16|    1992|    2007|       1
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 1992- 2007 (37.57/14.80)	QQQQQQQQ....QQQQQQQQ
 2021- 2036 (32.18/11.62)	QQQQQQIL....RQQQQQQQ
 2037- 2052 (37.57/14.80)	QQQQQQQQ....QQQQQQQQ
 2053- 2068 (33.44/12.37)	QQQHQQQQ....QQQAAPPQ
 2069- 2088 (24.30/ 6.98)	PQPQSQPQvaagLQPQAQGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     112.31|      18|      18|    1675|    1692|       2
---------------------------------------------------------------------------
  666-  682 (25.47/ 8.93)	PDFSLFSP....TMPCEGKGS
 1675- 1692 (32.13/13.43)	PRAYYLEP...LPLPPEDEEP
 1693- 1713 (27.32/10.19)	PAPTLLEPekkAPEPPKTDKP
 1736- 1752 (27.38/10.23)	P.ATKTED...YGMGPGRSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     244.61|      74|     233|     331|     411|       3
---------------------------------------------------------------------------
  331-  411 (122.20/102.02)	TPAPQ..PPTSSTPSTPFSD..LLMCPQHRPLVFglSCILQTILLCCPSALVwhYSLTDSRikTGSPLDHLPIAP..........SNLPMPeGNS
  560-  647 (122.42/78.16)	TQAPMltDPRSESERVEFFNlvLLFCELIRHDVF..SHNMYTCTLISRGDLA..FGAPGPR..PPSPFDDPADDPehkeaegsssSKLEDP.GLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.19|      72|     233|    1083|    1159|       4
---------------------------------------------------------------------------
 1083- 1159 (110.47/80.98)	LLEDLIRcAAIPSLLNAAcsEQDSEPGArlTCRILLHLFKT.PQLNPCQSDG...NKPTVG.IRSSCDRHLLAASQNRIVDG
 1319- 1395 (102.72/59.26)	LLENIAK.ATIEVFQQSA..ETGSSSGS..TASNMPSSSKTkPVLSSLERSGvwlVAPLIAkLPTSVQGHVLKAAGEELEKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     338.72|      74|     233|    1566|    1644|       5
---------------------------------------------------------------------------
 1566- 1639 (115.47/67.90)	GERQSDS..LEKVRQLLPLPK.QTRDVITCEPQGSLIDTKGNKIAGFD......SIFK......KEGLQVSTKQKIS.PWDLFEG.........LKPSA
 1757- 1788 (39.91/16.34)	.........VPP..DLLHHPN.PGSITHLNYRQGSI.........GL.........YT......QNQP...............................
 1792- 1875 (102.19/53.24)	GGPRVDP..YRPVR..LPMQKlPTRPTY...P..GVLPTTMTGVMGLEpssyktSVYR......QQQPAVPQGQRLRqQLQQSQGmlgqssvhqMTPSS
 1917- 1975 (81.15/42.13)	THPSTNPtlVDPTR...HLQQ.........RPSGYVHQQAPTYGHGLT......STQRfshqtlQQTPMIST......................MTPMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.28|      14|     233|     729|     742|       6
---------------------------------------------------------------------------
  729-  742 (28.15/18.22)	SCSHECNQ..RLVVLF
  965-  980 (22.12/12.69)	SCSHLKNKfgELFSLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.66|      40|     596|     237|     315|       8
---------------------------------------------------------------------------
  248-  293 (62.32/90.42)	MLDRHEFLTWVLECFEkirpGEDELLKLLLPLLlrYS......GEFVQSAYL
 1416- 1461 (66.33/22.37)	LLSQQPFLSLVLTCLK....GQDEQREGLLTSL..YSqvhqivNNWRDDQYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.85|      15|     233|    1228|    1257|      14
---------------------------------------------------------------------------
 1032- 1046 (30.98/ 8.23)	EWLG..VLKALCCSSNN
 1231- 1247 (26.87/26.34)	EWVGerCLKSLCEDSND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.70|      14|      23|    1502|    1515|      15
---------------------------------------------------------------------------
 1502- 1515 (24.50/13.51)	LLEIIISGTV..DMQS
 1526- 1541 (20.20/10.00)	MLSVLINGTLaaDMSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27835 with Med12 domain of Kingdom Metazoa
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