<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27809

Description Mediator complex subunit 14
SequenceHLPWQLENHQLVPPGGGGGGSSGPASAPAPPPPGAAVAAAAAAAASPGYRLSTLIEFLLHRAYSELMVLTDLLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKTEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPGNLHAASSPSGALRAPSPASFVPTPPPSSHGLSIGPGASFASPHGALDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNNLLMPSPTPGFVPGLAGSYLCSPLERFLGSVIMFKTDALKCRVALSPKTNQTLQLKVTPENTGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGGRP
Length626
PositionTail
OrganismMyotis lucifugus (Little brown bat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Microchiroptera> Vespertilionidae> Myotis.
Aromaticity0.06
Grand average of hydropathy-0.075
Instability index51.33
Isoelectric point9.57
Molecular weight66885.63
Publications
PubMed=21993624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27809
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     163.13|      36|     234|       9|      47|       2
---------------------------------------------------------------------------
    9-   44 (62.90/19.64)	HQLVPPGGGGGGSSGPAS.APAP...PPPGAAVAAAAAAA
  245-  280 (59.71/18.13)	HAASSPSGALRAPS.PASfVPTP...PPSSHGLSIGPGAS
  340-  370 (40.53/10.80)	H...SPRAGTSSQTMPTN.MPPPrklPQRSWAASI.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.06|      24|      24|     535|     558|       3
---------------------------------------------------------------------------
  534-  557 (39.65/22.19)	KMLFFL..QLTQKTSVPPQEPVSIIV
  558-  583 (34.41/18.14)	PIIYDMasGTTQQADIPRQQNSSVAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.84|      13|      15|     451|     465|       4
---------------------------------------------------------------------------
  451-  465 (18.69/17.14)	QVLEKFfeTRVAGPP
  469-  481 (22.14/12.35)	NTLIAF..TKLLGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.78|      31|      31|      66|      96|       5
---------------------------------------------------------------------------
   66-   96 (49.61/33.45)	LMVLTDLLPRKSDVERKIEIVQFASRTRQLF
   99-  129 (51.17/34.71)	LLALVKWANNAGKVEKCAMISSFLDQQAILF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.31|      11|      17|     307|     317|       6
---------------------------------------------------------------------------
  307-  317 (22.28/10.18)	PGSPQVSGPSP
  326-  336 (22.04/ 9.98)	PANPSLHSPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.64|      11|      17|     140|     150|       7
---------------------------------------------------------------------------
  140-  150 (19.70/10.47)	ARDALVHARLP
  199-  209 (17.93/ 8.90)	LRHRLVTTDLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27809 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FEATLTVMGDDPGNLHAASSPSGALRAPSPASFVPTPPPSSHGLSIGPGASFASPHGALDPSSPYTMVSPSGRAGNWPGSPQVSGPSPATRLPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWA
230
367










Molecular Recognition Features






MoRF SequenceStartStop




NANANA