<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27806

Description Mediator complex subunit 25
SequenceMVPGSEGPARAGGLVADVVFVIEGTANLGPYFEGRKHYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGCTTESLVQKIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLEPLQPPADVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQPVSLPPAPSSSAALSAAPQQSLPSVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPIKPSAAGAPGGPPFSQAQAPALPQGPPGAPKPVSPLPSPTWSPRWLPVQGLAPTAQPGAPVHQAGTVAPGGVNGPSPAQLGASALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNQGENLKTEQWPQKLIMQLIPPATAETTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGAQQAPPGLGPILEDQTRPSPNLLQLRPPQPQPQGTVGASAAVGQPQPQSAAQAPPGAAQGPPGAAPGPLPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPQQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length747
PositionUnknown
OrganismMyotis lucifugus (Little brown bat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Microchiroptera> Vespertilionidae> Myotis.
Aromaticity0.05
Grand average of hydropathy-0.242
Instability index60.43
Isoelectric point8.82
Molecular weight78302.90
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27806
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.06|      32|      41|     592|     632|       2
---------------------------------------------------------------------------
  310-  351 (50.77/ 9.86)	AG......APGGP.PFSQAQA.PALPQGPPG.APKPVSPLpsptwsprwlP
  593-  637 (43.29/19.08)	QGtvgasaAVGQPqPQSAAQApPGAAQGPPGaAPGPLPPG......pilrP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     518.42|     115|     161|     183|     302|       3
---------------------------------------------------------------------------
  183-  239 (67.92/21.68)	.....................................................................................................................................................S.PRKLPA.LRLLFekaAPPA....MLEPLQPPADVS.............................................Q...DPRHMVLVRGLVLPVGGGSAPGPLQ
  240-  383 (146.36/51.24)	PKQPV...SLP.P.APSSSAA..................L....SAAPQQSLPSVPQQY..........QVPG.NLSAAQVaaQNAVEAAKN...QKA..GLGPRFspikpsaagapggppfsqaqapalpqgppgapkpvsplpsptwS.PRWL..pVQGL....APTA.........QPGAPVH.............................................Q...........AGTVAP.GGVNGPSPAQ
  401-  497 (107.35/33.30)	AWSGVlewQEK.P.KPASVDA.......................NTKLTRSLPC..QVY..........VNQGeNLKTEQ......................................................................wPQKL...IMQLI....PPAtaetTLGPLFRNSRMV.............................................QfhfTNKDLESLKGLYRIMGNGFA.G...
  498-  657 (107.78/33.46)	...CV...HFPhT.APCEVRV..................LmllySSKKKIFMGLIP..YdqsgfvngirQVIT.NHKQVQ...QQKLEQQRGmgaQQAppGLGPIL...........................................E.DQTRPS...........PN....LLQ.LRPPQPQPqgtvgasaavgqpqpqsaaqappgaaqgppgaapgplppgpilrpQ...NPGANPQLRSLLL......NPPPPQ
  661-  734 (89.01/26.27)	PPQQA...SLH.HlQPPGAPAllppphqglgqpqlgpplL....HPPPAQSWP.........................AQL......................................................................................PPR......APL.........................................................PGQMLLSGG...PRGPVPQPG.LQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.92|      30|     111|      38|      68|       4
---------------------------------------------------------------------------
   38-   68 (53.43/30.58)	YLLPAIEYFN.GGPPAETdFGGDYG..GTQYSLV
  150-  182 (44.49/21.03)	YLLPAVESTTySGCTTES.LVQKIGerGIHFSIV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27806 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQPVSLPPAPSSSAALSAAPQQSLPSVPQQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPIKPSAAGAPGGPPFSQAQAPALPQGPPGAPKPVSPLPSPTWSPRWLPVQGLAPTAQPGAPVHQAGTVAPGGVNGPSPAQLGASALG
2) HKQVQQQKLEQQRGMGAQQAPPGLGPILEDQTRPSPNLLQLRPPQPQPQGTVGASAAVGQPQPQSAAQAPPGAAQGPPGAAPGPLPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPQQASLHHLQPPGAPALLPPPHQGLGQPQLGPPLLHPPPAQSWPAQLPPRAPLPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
231
545
390
745










Molecular Recognition Features






MoRF SequenceStartStop




NANANA