<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27795

Description Mediator complex subunit 12 like
SequenceQDELTAVNVKQGFSNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTPRSQSAIHSWFSELAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRAMWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQLAKISDFYHMASSMGDGPVPVPPDVEQALKQWEYNAKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSSGLLTAHSPHMMIGPNNASIGAPSPGPPGPGVSPVQLAFSDFLSCAQHGPLIYGLSCMLQTVTLCCPSALVWNYSTNDSKSVNPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSLRRFIASSSEGLRPEFENHEVAPSDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKAEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTSSTRPRSPSGENADEHYPKDHDMKMEAPGLSYSKDFNMSVRLLLFVSKEKFSVSKFKITLRCRGRGEGDPQRTDIRKEVKPARARGSRGTLGRVYNQKRNKGFTVHFSVFQDESSSHECNQRTVLLYGVGKARDEARHQLKKITRDILKILNKKSTTEMGVYTPLPPVTSPSSLCFNVGDEGPRARKNRQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFSIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPEQTAQVFEGLCSVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSLSSACSKVKQTIYNNVIPANSNLRWDPDFMMDFIENPSACSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACLLPQAAGKTFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNSVSSLKNDDFTMRGLRRDGNADDIWTASQTAKSCGRSISIETANLKEYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPVAEMNNLLDNIAKATIEVFQQSADMSINSSNSGSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLMSLQNQVNQILSNWREERYQHDLKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNALPGGSEENRRAYMNLVKKLKKELGDKRSESIDKVQQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRIDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDVSAGSRGNLYSPSLTPDDLLDEAQVPGAIVHILASQSYLAICYSNQRCFVGGSRLDPTGSFVPTNTKQALSNMLQRRSGALMQPPSLHAITSQQQQLVQMKLLQQQQRLLRQAQARPCQQNALSKSCIHEHGGSSSELYFLAMPQGYTMYGTQMPLQQTPQQQAGSVVLSPSYNSRTYPVAHSNPTLMERLRQMQQPPSGYIQQQASQYLQPLTGSQRLNHQSLQQSPLMGGGVDAVLTPTHPNLPSVPLPQDPMRPRQPQVRQQQRLLQKCQQAVSIYCIALKKKNKLEDSIHTELENAKDEKNFLKKQKRNTTNESSSSSRCHRMQQSQQPPQPQPSSQPQSQPLSLQAVQPQQ
Length2134
PositionKinase
OrganismMyotis lucifugus (Little brown bat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Microchiroptera> Vespertilionidae> Myotis.
Aromaticity0.07
Grand average of hydropathy-0.372
Instability index54.49
Isoelectric point8.46
Molecular weight238528.89
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IEA:Ensembl

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27795
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     300.86|     100|     651|     778|     879|       1
---------------------------------------------------------------------------
  778-  879 (158.67/111.53)	GDE.......GPRARKNR....QEAFPTL.ETVFTKLQL..LSYFDQHQVTSQIS.NNVLEQITSFASGTSYHLPLAHHiQLIFDLMEPALN.INGLIDfSIQLLNELSVVEAELLLK
 1430- 1545 (142.20/91.10)	GEElekgqhlGSSSKKERdrqkQKSMSLLsQQPFLSLVLtcLKGQDEQREGLLMSlQNQVNQILSNWREERYQHDLKAR.QMMHEALQLRLNlVGGMFD.TVQRSTQWTTDWALLLLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.40|      16|      66|    1934|    1949|       2
---------------------------------------------------------------------------
 1934- 1949 (30.02/13.35)	LQQTPQQQAG.SVVLSP
 2002- 2018 (23.39/ 8.90)	LQQSPLMGGGvDAVLTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.59|      23|      68|     570|     594|       3
---------------------------------------------------------------------------
  570-  594 (38.76/38.43)	LLFceFIRHDVFSHDAYMCTLISRG
  641-  663 (39.83/30.10)	LLL..FVSKEKFSVSKFKITLRCRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.77|      26|      32|     952|     983|       4
---------------------------------------------------------------------------
  943-  969 (44.41/27.67)	YlYDLYVSCSHLR..SKF.GDLFSLSSACS
  976- 1004 (40.36/15.08)	Y.NNVIPANSNLRwdPDFmMDFIENPSACS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.70|      34|     204|    1057|    1092|       5
---------------------------------------------------------------------------
 1057- 1092 (57.03/41.61)	TVLSSEWLG..VLKA...LCCSSNHVwgFNDVLCTVDVSDL
 1263- 1301 (50.67/29.19)	TICQQEWVGehCLKEperLCTDKELI..LDPVLSNMQAQKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     157.80|      26|      67|    1973|    1998|      11
---------------------------------------------------------------------------
 1861- 1888 (32.16/15.35)	.QPPSLHAitsQQQQLVQMKL.LQQQQRLL
 1973- 1998 (48.23/27.47)	QQPPSGYI...QQQASQYLQP.LTGSQRLN
 2024- 2046 (26.00/10.71)	...PSVPL...PQDPMRPRQPqVRQQQRL.
 2050- 2068 (19.89/ 6.09)	.......C...QQAVSIYCIA.LKKKNKLE
 2109- 2125 (31.53/14.87)	QQPP.......QPQPSS..QP...QSQPL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.45|      20|      69|    1105|    1138|      15
---------------------------------------------------------------------------
  917-  937 (34.29/11.20)	FeGLCSVVKHVVNPS....ECSSPE
 1111- 1134 (31.16/23.95)	F.SLEDVVQHVALPSllaaACGDAD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27795 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EDSIHTELENAKDEKNFLKKQKRNTTNESSSSSRCHRMQQSQQPPQPQPSSQPQSQPLSLQAVQPQQ
2) PLTGSQRLNHQSLQQSPLMGGGVDAVLTPTHPNLPSVPLPQDPMRPRQPQVRQQQRL
3) RSYYLEPLPLPPEEEEEEPTSPISQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKSSSRVDVSAGSRGNLYSPSLTPDD
4) YPVAHSNPTLMERLRQMQQPPSGYIQQQASQ
2068
1990
1717
1956
2134
2046
1796
1986










Molecular Recognition Features






MoRF SequenceStartStop




NANANA