Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | KMENFTALFGAQADPPPPPTALGFGPGKPPPPPPPPPGGGPGTAPPPTAATAPPGADKSAAGCGPFYLMRELPGSTELTGSTNLITHYNLEHAYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDHPGMGSSQASSSSSLR |
Length | 245 |
Position | Head |
Organism | Myotis lucifugus (Little brown bat) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Microchiroptera> Vespertilionidae> Myotis. |
Aromaticity | 0.04 |
Grand average of hydropathy | -1.027 |
Instability index | 64.95 |
Isoelectric point | 9.86 |
Molecular weight | 26403.96 |
Publications | PubMed=21993624 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP27790 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 79.91| 16| 16| 191| 206| 2 --------------------------------------------------------------------------- 171- 184 (25.73/10.55) P..PKKKNKHKHKQSR 191- 206 (27.40/11.64) PETPSDSDHKKKKKKK 210- 225 (26.77/11.23) PERKRKKKEKKKKKNR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 43.68| 13| 114| 115| 131| 5 --------------------------------------------------------------------------- 115- 131 (19.80/21.32) GMidlpGSHDNSSLRSL 232- 244 (23.88/13.45) GM....GSSQASSSSSL --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GFGPGKPPP 2) KMENFTALFG 3) SDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPD | 23 1 197 | 31 10 229 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab