<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27788

Description Mediator complex subunit 12
SequenceMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPSKISSNFSNIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTPRSQSAINTWFTDLAGTKPLTQLAKKVPIFGKKDEVFGYLAKYTVPVMRAAWLIKMTCAYYAAINETKVKKRNTIDPFIEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVELAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGMSSHSAHVMSAQSTSTLPTTPAPQPPTSSTPSIPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNIYTCTLISRGDLAFGAPGPRPPSPFDDPADDPERKEAECNSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKADVEKEVKPPPKEKMEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKIKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGTGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSFGNTASNMPSSNKAKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVNQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKITGFDSIFKKEQGLQVSTKQRLSPWDLFEGLKPSAPLSWGWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPASTEERKKKSTKGKKRSQPAAKTEDFGMGSGRSGPYGVTVPPDLLHHTNPGSITHVSYRQGPIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPARPPYPGVLPTTMSGVMGLEPSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTTSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMIGTLTPLSTQGVQAAVRSAAILPEQQQQQPPQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQILRQQQQQQQQQQQQQQQQQQAHQQQQQQQQQQQQQQQAAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2187
PositionKinase
OrganismMyotis lucifugus (Little brown bat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Microchiroptera> Vespertilionidae> Myotis.
Aromaticity0.07
Grand average of hydropathy-0.504
Instability index57.47
Isoelectric point6.70
Molecular weight244240.18
Publications
PubMed=21993624

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27788
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     171.11|      18|      18|    2062|    2079|       1
---------------------------------------------------------------------------
 2054- 2070 (36.71/12.55)	EQQQQ.QPPQ...QQQQQQQQ
 2071- 2089 (31.95/10.04)	QQQQQ.QQQQ.qQQQYHIRQQ
 2090- 2108 (33.85/11.04)	QQQQQiLRQQ..QQQQQQQQQ
 2109- 2126 (40.31/14.46)	QQQQQ.QQAH..QQQQQQQQQ
 2127- 2146 (28.30/ 8.11)	QQQQQ.QAAAppQPQPQSQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     161.77|      73|     613|      13|      95|       2
---------------------------------------------------------------------------
   13-   54 (35.00/21.34)	...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................PLKRPRlGPPDVYPQDPKQKEDEltaLNVKQGFNNqPAVSGD
   55-   95 (28.98/18.88)	EHGSAKNVNFNPSKiSSNFSnIIAEKLRCNtlpDTGRRKPQ................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  630-  666 (51.74/18.55)	.........................................vnqkdnfwlvtprsqsaintwftdlagtkpltqlakkvpifgkkdevfgylakytvpvmraawlikmtcayyaainetkvkkrntidpfiewtqiitkylweqlqkmaeyyrpgpagsggcgstigplphdvelairqwdyneklamfmfqdgmldrhefltwvlecfekirpgedellklllplllrysgefvqsaylsrrlayfctrrlalqldgmsshsahvmsaqststlpttpapqpptsstpsipfsdllmcpqhrplvfglscilqtillccpsalvwhysltdsriktgspldhlpiapsnlpmpegnsaftqqvraklreieqqikergqavevrwsfdkcqeatagftigrvlhtlevldshsfersdfsnsldslcnrifglgpskdgheissdddavvsllcewavsckrsgrhramvvakllekrqaeieaercgeseaadekgsiasgslsapsapifqdvllqfldtqapmltdprseserveffnlvllfcelirhdvfshniytctlisrgdlafgaPGPRPP.SPFDDPADDPERKEAE...CNSSSKLED.PGLSES
  668-  703 (46.04/15.55)	DIDPSSSVLFEDME.KPDFS.LFSPTMPCE...GKGSPSPE................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.10|      28|     612|     523|     552|       3
---------------------------------------------------------------------------
  523-  552 (42.61/33.36)	AMVVAK...LLEK..RQAEIEA...ERCGESEAadEKG
 1134- 1169 (34.49/20.01)	AILIARqclLLEDliRCAAIPSllnAACSEQDS..EPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.45|      15|      20|    1741|    1755|       4
---------------------------------------------------------------------------
 1741- 1755 (30.11/15.39)	LEP...LPLPPEDEEPPA
 1759- 1776 (25.34/11.54)	LEPekkAPEPPKTDKPGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     161.61|      33|     230|    1921|    1953|       5
---------------------------------------------------------------------------
 1875- 1907 (35.15/16.01)	PYPGVLPT................TMSGVMGLEPSyktsvyRQQQPAVP
 1921- 1953 (61.26/34.41)	QSQGMLGQSS..........VHQMTTSSSYGLQTS......QGYTPYVS
 1962- 1979 (30.42/12.68)	GPAGTM...................VPPSYS...S......Q...PYQS
 1983- 2021 (34.79/15.76)	STNPTLVDPTrhlqqrpsgyVHQQAPTYGHGLTST......QRF....S
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     223.15|      56|     125|    1491|    1554|      13
---------------------------------------------------------------------------
 1491- 1548 (85.17/56.69)	KGQDEQREGLLTSLySQVNQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGmFDTV
 1620- 1672 (82.31/45.00)	KLQKELGERQSDSL.EKVRQLLPLPKQTRDVITCEPQGSL...IDTKGNKITG.FDSI
 1697- 1735 (55.67/32.06)	KPSAPLSWGWFGTV..RVDRRVARGEEQQRL......LLYHTHLRPR...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.54|      19|     124|    2022|    2047|      15
---------------------------------------------------------------------------
 1833- 1854 (32.87/ 9.20)	HVSYRQGP.IGLYTqnqPLPAGG
 2022- 2041 (31.67/22.03)	HQTLQQTPmIGTLT...PLSTQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.61|      59|     200|    1346|    1408|      18
---------------------------------------------------------------------------
 1346- 1408 (93.97/94.88)	KRILQNLDQWTMrqssLELQLMIKQT....PNNEMNS....LLENIAKATIEVFQQSAETGSSFGNTASNM
 1549- 1615 (86.64/75.17)	QRSTQQTTEWAV....LLLEIIISGTvdmqSNNELFTtvldMLSVLINGTLAADMSSISQGSMEENKRAYM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27788 with Med12 domain of Kingdom Metazoa
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