<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27787

Description Mediator of RNA polymerase II transcription subunit 15
SequenceEDAMRKAGVAHSKSSKDMESHVFLKAKTREEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQFQQQQAALQQQQQQQFQAQQNAMQQQFQAVVQQQQQQLQQQQQQQQHLLKLHHQNQQQIQQQQQLQRMAQLQLQQQQQQQALQAQPPMQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPQPQPQQPPVAQNQPSQLPPQSQTQPLVSQAPALPGQMLYPQPPLKLVRAPMVVQQPQVQPPVQQQTAPTAQAPQIVGSGVQMIAEALAQGGMQVRARFPPTTAVSAVQSSSIPLGREPSAQEIWNSSMVNWCISNPVPSKKKGTAQVGTPPPPPECTNFCAPNTGQSKXPCPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRKLEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAESIHQACLSAA
Length750
PositionTail
OrganismMyotis lucifugus (Little brown bat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Microchiroptera> Vespertilionidae> Myotis.
Aromaticity0.03
Grand average of hydropathy-0.647
Instability index81.36
Isoelectric point9.30
Molecular weight82280.95
Publications
PubMed=21993624

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
nucleoplasm	GO:0005654	IEA:Ensembl
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27787
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     135.92|      18|      19|     133|     150|       1
---------------------------------------------------------------------------
  133-  150 (37.76/ 9.95)	QQVALQQQQQQQQQFQQQ
  174-  191 (34.02/ 8.07)	QAVVQQQQQQLQQQQQQQ
  235-  252 (32.39/ 7.25)	QQPPMQQPQPPPSQALPQ
  253-  270 (31.75/ 6.93)	QLQQMHHPQHHQPQPQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.40|      19|      19|     305|     323|       2
---------------------------------------------------------------------------
  298-  322 (30.50/ 7.53)	LPQPPLKLVRAPMVVQQPQ
  443-  461 (28.90/ 6.72)	LPSPSPQPSQSPVTARTPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.67|      23|     150|     405|     431|       4
---------------------------------------------------------------------------
  354-  374 (33.46/ 6.17)	QGGMQVRARFPP..TTAVSAVQS
  375-  396 (30.36/ 6.67)	.SSIPLGREPSAQEIWNSSMVNW
  407-  429 (46.85/23.07)	KGTAQVGTPPPPPECTNFCAPNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.87|      17|      19|      63|      79|       5
---------------------------------------------------------------------------
   63-   79 (32.91/16.84)	QSLTGGPAAGAAGI...GMP
   85-   99 (29.43/14.20)	QSLGGMGGLGA..M...GQP
  100-  118 (23.53/ 9.72)	MPLSGQPPPGTSGMaphGM.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.22|      15|      21|     195|     209|       6
---------------------------------------------------------------------------
  195-  209 (27.70/ 8.66)	LKLHHQNQQQIQQQQ
  217-  231 (26.23/ 7.74)	LQLQQQQQQQALQAQ
  280-  294 (25.29/ 7.15)	SQLPPQSQTQPLVSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.40|      23|      28|     525|     551|       7
---------------------------------------------------------------------------
  516-  543 (35.23/21.80)	DKNEdrkkdLSKMKSLLDILTDPSKRCP
  548-  572 (39.17/16.36)	QKCE...iaLEKLKNDMAVPTPPPPPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.05|      11|     140|     462|     500|       8
---------------------------------------------------------------------------
  462-  476 (15.22/13.96)	NFsvpsPGPLNTPVN
  503-  513 (18.83/12.03)	KY....IEPLRRMIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.41|      42|     128|     575|     618|      10
---------------------------------------------------------------------------
  577-  618 (74.87/59.97)	QYLCQPLLDAVLANIRSPVF....NHSLYRTFVPAMTAIHGPPITA
  704-  749 (68.54/47.20)	QYDANPFLQSVHRCMTSRLLqlpdKHSVTALLNTWAESIHQACLSA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27787 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPSRGPGQSLGGMGGLGAMGQPMPLSGQPPPGTSGMAPHGMAVVSTAT
2) NPVPSKKKGTAQVGTPPPPPECTNFCAPNTGQSKXPCPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQ
3) QQQQQQALQAQPPMQQPPMQQPQPPPSQALPQQLQQMHHPQHHQPQPQPQQPPVAQNQPSQLPPQSQTQPLVSQAPALPGQMLYPQPPLKLVRAPMVVQQPQVQPPVQQQTAPTAQAPQIVGSGVQMIAEALAQGGMQVRARFPPTTAVSAVQSSSIPLGREPSA
47
400
221
125
500
385










Molecular Recognition Features






MoRF SequenceStartStop




1) FGEEYFD
2) GIRLLPEYSTEKHKKHKKEKKKVKDK
3) KKPSLTAVIDKLKHGVV
4) PITKHG
5) PKITIQIPKGT
6) RLSPDFMIGEEDDDLMDVALI
7) SIKAKVTLQK
8) VAKIIISKH
878
1479
1294
1154
1059
1553
1397
1383
884
1504
1310
1159
1069
1573
1406
1391