Description | Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MKAQGETEESEKLSKMSSLLERLHAKFNQNRPWSETIKLVRQVMEKRVVMSSGGHQHLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSASGTECYITSDMFYVEVQLDPAGQLCDVKVAHHGENPMSCPELVQQLREKNFEEFSKHLKGLVNLYNLPGDNKLKTKMYLALQSLEQDLSKMAVMYWKATNAGPLDKILHGSVGYLTPRSGGHLMNLKYYASPSDLLDDKTTSPIILHENNVPRSLGMNASVTIEGTSAMYKLPIAPLIMGSHPVDNKWTPSFSSITSANSVDLPACFFLKFPQPIPVSRAFVQKLQNCTGIPLFETPPTYIPLYELITQFELSKDPDPIPLKHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLVSKITFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTILKEDSPGLLQFEVCPLSESRFSVSFQHPVNDSLVCVVMDVQDSTHVSCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTNTFPGGPITTLFNMSMSIKDRHESVGHGEDFSKVSQNPILTSLLQITGNGGSTIGSSPTPPHHTPPPVSSMAGNTKNHPMLMNLLKDNPAQDFSTLYGCSPLERQNSSSGSPRMEMCSGSNKTKKKKSSRLLPEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPVPHPQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSDDCPPIGTPVRDSSSSGHSQSALFDPDVFQANNNENPYTDPADLIADAAGSPSSDSPSNHFFPDGVDFNPDLLNSQSQSGFGEEYFDESSQSGDNDDFKGFTSQALNTLGVPMLGGDNGETKFKGNSQADTVDFSIIAVAGKALGSADLMEHHSGSQSPLLTTGDLGKDKAQKRVKEGNGTSNSLTGPGLDSKPGKRSRTPSNDGKSKDKPPKRKKADTEGKSPSHSSNRPFTPPTSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVMVGKPSSHSQYTSSGSVSSSGSKSHHSHSSSSSSSASNSGKMKSSKSEGSSSKLSSSIYSSQGSSGSSQSKNSSQSGGKPGSSPITKHGLSSGSSGTKMKLQGKPSSLMNPSLSKPNISPSHSRPPGGSDKLASPMKSVPGTPPSSKAKSPISSGSSGSHMSGTGSSTGMKSSSGLGSSGSLKTPPSSNSCTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGEDPMDGQVGVSTNSSHPMSSKHNMSGGEFQGKREKSDKDKSKVSTSGGSVDSSKKTSESKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGESSGEGLRPQMASSKNYGSPLISGSTPKHERGSPSHSKSPAYTPQNLDSESESGSSIAEKSYQNSPCSDDGIRLLPEYSTEKHKKHKKEKKKVKDKDRDRDRDKDRDKKKSHSIKPESWSKSPISSDQSLSMTSNTILSTDRPSRLSPDFMIGEEDDDLMDVALIGN |
Length | 1575 |
Position | Middle |
Organism | Myotis lucifugus (Little brown bat) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Chiroptera> Microchiroptera> Vespertilionidae> Myotis. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.665 |
Instability index | 52.63 |
Isoelectric point | 8.88 |
Molecular weight | 167939.96 |
Publications | PubMed=21993624 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059 |
GO - Cellular Component | mediator complex GO:0016592 ISS:UniProtKB nucleolus GO:0005730 ISS:UniProtKB nucleoplasm GO:0005654 IEA:Ensembl nucleus GO:0005634 ISS:UniProtKB |
GO - Biological Function | chromatin binding GO:0003682 ISS:UniProtKB DNA binding GO:0003677 IEA:Ensembl estrogen receptor binding GO:0030331 IEA:Ensembl LBD domain binding GO:0050693 IEA:Ensembl nuclear receptor coactivator activity GO:0030374 ISS:UniProtKB peroxisome proliferator activated receptor binding GO:0042975 IEA:Ensembl promoter-specific chromatin binding GO:1990841 IEA:Ensembl protein-containing complex binding GO:0044877 IEA:Ensembl retinoic acid receptor binding GO:0042974 IEA:Ensembl thyroid hormone receptor binding GO:0046966 ISS:UniProtKB transcription coactivator activity GO:0003713 ISS:UniProtKB transcription coregulator activity GO:0003712 ISS:UniProtKB transcription corepressor activity GO:0003714 ISS:UniProtKB vitamin D receptor binding GO:0042809 IEA:Ensembl |
GO - Biological Process | androgen biosynthetic process GO:0006702 ISS:UniProtKB angiogenesis GO:0001525 ISS:UniProtKB animal organ regeneration GO:0031100 IEA:Ensembl brain development GO:0007420 IEA:Ensembl cell morphogenesis GO:0000902 ISS:UniProtKB cellular response to epidermal growth factor stimulus GO:0071364 ISS:UniProtKB cellular response to hepatocyte growth factor stimulus GO:0035729 IEA:Ensembl cellular response to thyroid hormone stimulus GO:0097067 IEA:Ensembl embryonic heart tube development GO:0035050 IEA:Ensembl embryonic hemopoiesis GO:0035162 IEA:Ensembl embryonic hindlimb morphogenesis GO:0035116 IEA:Ensembl embryonic placenta development GO:0001892 IEA:Ensembl enucleate erythrocyte development GO:0048822 IEA:Ensembl epithelial cell proliferation involved in mammary gland duct elongation GO:0060750 IEA:Ensembl erythrocyte development GO:0048821 ISS:UniProtKB fat cell differentiation GO:0045444 IEA:Ensembl intracellular steroid hormone receptor signaling pathway GO:0030518 ISS:UniProtKB keratinocyte differentiation GO:0030216 ISS:UniProtKB lactation GO:0007595 IEA:Ensembl lens development in camera-type eye GO:0002088 ISS:UniProtKB liver development GO:0001889 IEA:Ensembl mammary gland branching involved in pregnancy GO:0060745 IEA:Ensembl mammary gland branching involved in thelarche GO:0060744 IEA:Ensembl megakaryocyte development GO:0035855 ISS:UniProtKB monocyte differentiation GO:0030224 IEA:Ensembl mRNA transcription by RNA polymerase II GO:0042789 ISS:UniProtKB negative regulation of apoptotic process GO:0043066 ISS:UniProtKB negative regulation of keratinocyte proliferation GO:0010839 ISS:UniProtKB negative regulation of neuron differentiation GO:0045665 ISS:UniProtKB negative regulation of transcription by RNA polymerase II GO:0000122 ISS:UniProtKB peroxisome proliferator activated receptor signaling pathway GO:0035357 IEA:Ensembl positive regulation of erythrocyte differentiation GO:0045648 IEA:Ensembl positive regulation of G0 to G1 transition GO:0070318 IEA:Ensembl positive regulation of gene expression GO:0010628 ISS:UniProtKB positive regulation of hepatocyte proliferation GO:2000347 IEA:Ensembl positive regulation of interferon-gamma-mediated signaling pathway GO:0060335 IEA:Ensembl positive regulation of intracellular estrogen receptor signaling pathway GO:0033148 IEA:Ensembl positive regulation of keratinocyte differentiation GO:0045618 ISS:UniProtKB positive regulation of transcription by RNA polymerase II GO:0045944 ISS:UniProtKB positive regulation of transcription initiation from RNA polymerase II promoter GO:0060261 ISS:UniProtKB protein import into nucleus GO:0006606 IEA:Ensembl regulation of RNA biosynthetic process GO:2001141 ISS:UniProtKB regulation of vitamin D receptor signaling pathway GO:0070562 IEA:Ensembl retinal pigment epithelium development GO:0003406 IEA:Ensembl thyroid hormone generation GO:0006590 IEA:Ensembl thyroid hormone mediated signaling pathway GO:0002154 ISS:UniProtKB ventricular trabecula myocardium morphogenesis GO:0003222 IEA:Ensembl |
Binary Interactions |
Repeats |
MoRF Sequence | Start | Stop |
1) FGEEYFD 2) GIRLLPEYSTEKHKKHKKEKKKVKDK 3) KKPSLTAVIDKLKHGVV 4) PITKHG 5) PKITIQIPKGT 6) RLSPDFMIGEEDDDLMDVALI 7) SIKAKVTLQK 8) VAKIIISKH | 878 1479 1294 1154 1059 1553 1397 1383 | 884 1504 1310 1159 1069 1573 1406 1391 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab