<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27768

Description Mediator complex subunit 14
SequenceASSRLQPFSLAPPLRSAISPPVQPSPRNRPATAAPTTAAATTQPLPXYRLSTLIDFLLHRTYAELTVLADLLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLALQLEVLHSQTLMLIRERWGDLVQVERYHAGKCLSLSVWNQQVLGRKTGTASVHKVTIKIDETDVSKPLQISHEPPLPACDSKLMERAMKIDHLSIEKLLIDSVHARSHQKLQELKAILKSYNVNDNSFIETALPTLVIPILEPCGRSECLHVFVDLHSGMFQLMLYGVDQVTLDDIEKCVNDDMKRIIPWLQQLNARFWLGQQRCKQSIKHLPTVSSETLQLANHASHPVGNLSKHKLFIKLTRLPQYYIVVEMFDVPGNPTELEYKYYFLSVSYAEGDDNPATALLLQQFKPNIEELVLDTKSGKQMKSGVKRKLSGDPCSIEPKKPKRTGEMCAFNKVLAHIVAMCDTNMPFIGLRLELSNMDIPHQGVQVEGDGFSHAIRLLKNRIPPCKGVNEETQKALDRSLLDCTFRLQGRNNRTWVAELVFANCPLNSTSSREQGPTRHVYLTYENQLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPNHLNIFSEVRIYNYRKLILCYGTTKGSSISIQWNSILQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKTPNVVLLLQVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPIPDASHSPRAGTSSQAMPTSMPPPRKLPQRSWAASIPTILTHSALNVLLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTEALKCRVALNPKTNQTLQLKVTPENTGQWKSEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVSQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRPGECTIFAAVRDLMLNLTLPPGGRP
Length1460
PositionTail
OrganismMeleagris gallopavo (Wild turkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Meleagridinae> Meleagris.
Aromaticity0.07
Grand average of hydropathy-0.197
Instability index53.46
Isoelectric point9.00
Molecular weight162002.38
Publications
PubMed=20838655

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl
GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27768
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     280.79|      77|     282|    1060|    1146|       1
---------------------------------------------------------------------------
  986- 1043 (67.89/24.82)	................................NPPSPIGGDMMDSLISQLQPQQP....PQQ.PQ.............QPFAKQAGASG..AYPltspptSYHntvTPSP
 1060- 1146 (141.98/78.66)	PSGALRAPSPASFGPT..PSPSSLgitmgqtaNFASPHGTIDPSSPYTMMSPSQRagNWPGS.PQV...SG......PSPAARMPGMSP..ANP......SLH...SPIP
 1148- 1214 (70.92/27.93)	ASHSPRAGTSSQAMPTsmPPPRKL............................PQR..SWAASiPTIlthSAlnvlllPSPT...PGLVPglAGS......YLC...SPL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     190.84|      54|     399|     862|     929|       2
---------------------------------------------------------------------------
  862-  917 (89.93/50.23)	FNKTP.NVVLLLQVlfDTQAPLNAINKLPTVPM.......LGLTQRTNTAYQCFSILPQSPTHI
 1285- 1319 (43.49/16.58)	.....................LQVLEKFFETRV.......AGPPFKANTLI.AFTKLLGAPTHI
 1336- 1390 (57.42/30.03)	ASQLKwNVQFCLTI..PPSAPPIAPPGTPAVVLkskmlffLQLTQKTTVSQEAVSII.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.89|      18|     398|     222|     251|       3
---------------------------------------------------------------------------
  229-  246 (34.73/33.38)	FEATLTVMGDDPDIPWRL
  780-  797 (34.16/ 8.47)	YECVLEFARSLPDIPNHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.57|      19|     398|     421|     465|       4
---------------------------------------------------------------------------
  294-  313 (32.10/ 7.51)	CLHSFCLALQLEvLHSQT..LM
  445-  465 (33.47/19.28)	CGRSECLHVFVD.LHSGMfqLM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.75|      27|     486|     328|     354|       6
---------------------------------------------------------------------------
  328-  354 (50.37/32.81)	YHAGKCLSLSV.WN...QQ......VLGRKTGTASVH
  815-  851 (37.38/22.39)	YGTTKGSSISIqWNsilQKfhislgTVGPNSGCSNCH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27768 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQPPQQPQQPFAKQAGASGAYPLTSPPTSYHNTVTPSPSMMHTQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQTANFASPHGTIDPSSPYTMMSPSQRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPIPDASHSPRAGTSSQAMPTSMPPPRKLPQRSWA
973
1177










Molecular Recognition Features






MoRF SequenceStartStop




1) LQAASLYRLEE
2) PTEEYAQLFAALIARTAKDIDVLIDSLP
85
50
95
77