<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27766

Description Cyclin dependent kinase 19
SequenceRMKCKKLWETKQLCECGNNNSLSISLQLLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTSDVFAGCQIPYPKREFLNEDEPEEKGDKKQTKQKKQQQHKNQHKTTTERSEPQMTYPNLRHAAQTNGTAGGTGAGGGGAGAGLQHSQDSSLNQVPPNKKPRIGPSGANSGGPVMPSDYQHSSSRLSYQSNIQGSSQSQSTMGYSTSSQQSSQYHQSHQSHRY
Length463
PositionKinase
OrganismMeleagris gallopavo (Wild turkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Meleagridinae> Meleagris.
Aromaticity0.08
Grand average of hydropathy-0.739
Instability index58.69
Isoelectric point9.30
Molecular weight52830.43
Publications
PubMed=20838655

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27766
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      15|      41|     110|     124|       1
---------------------------------------------------------------------------
  110-  124 (26.77/14.82)	DLKPANILVMGEGPE
  148-  162 (28.67/16.27)	DLDPVVVTFWYRAPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.64|      27|      40|     236|     268|       2
---------------------------------------------------------------------------
  236-  268 (37.66/34.74)	PTlqkdfRRTTYANSSLIKYMEKHKVkPDSKVF
  279-  305 (48.98/27.84)	PT.....KRITSEQALQDPYFQEDPL.PTSDVF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.36|      19|      32|     371|     400|       3
---------------------------------------------------------------------------
  371-  391 (32.11/29.47)	GGTGAGGGG..AGAGLQHSqdSS
  404-  424 (34.25/10.36)	GPSGANSGGpvMPSDYQHS..SS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.16|      44|      53|       7|      55|       4
---------------------------------------------------------------------------
    7-   55 (66.38/43.53)	LWETKQLCECGNNNslSISLQLLRELKHPNVIA.LQKVFLSHSDrkvWLL
   63-  107 (73.78/37.32)	LWHIIKFHRASKAN..KKPMQLPRSMVKSLLYQiLDGIHYLHAN...WVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27766 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IPYPKREFLNEDEPEEKGDKKQTKQKKQQQHKNQHKTTTERSEPQMTYPNLRHAAQTNGTAGGTGAGGGGAGAGLQHSQDSSLNQVPPNKKPRIGPSGANSGGPVMPSDYQHSSSRLSYQSNIQGSSQSQSTMGYSTSSQQSSQYHQSHQSHRY
310
463










Molecular Recognition Features






MoRF SequenceStartStop




1) GPVMPS
2) LNQVPPNKKPRIGPS
3) SSRLSYQSNIQGS
4) STMGYSTSSQQSSQYHQSHQSHRY
412
392
423
440
417
406
435
463