<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27765

Description Mediator complex subunit 23
SequenceMETQLQSIFEEVVKTEVIEEAFPGMFMDTPEDERTKLVSCLSAFRQFWSSLSQESHEQCVQWIVRFIHSQHSPKRISFLYDCLAMAVESGLLPPRMVCESLINSDTLEWERTQLWALTFKLIRKIIGGVDYKGVRDLLKVILEKILTIPNTVSSAVVQQLLAAREVVAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAMCNSWKLDPTTLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAHSDNSKLQIPIPHSLKHHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGVLVETIYGNGNMRISLPGTNCMASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQRNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKSVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPAPLQVFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENEIITRFSVQGSPPLFLCLLWKMLLETDHINQIGYSDRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMSYHKKYPEKLYFEGLAEQVNPPVQIQPQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERHLRERTNLKRKLVHAIIGSLKDNRPLGWCLSDTYLKCAMNAREDNPWVPDDTYYCKLIGRLSLSPMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGTDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDHIVNVINSPSLTSETEWVGYPFQLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEVLIPIVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYEMLLNADQYSSHLNYMDPICDFLYHMKYMFTGDSVKDQVEKIICNLRPALKLRLRFITHISKMEPAGVSQQPLSNGSPAQQPSQVPVNVALPVTQ
Length1373
PositionTail
OrganismMeleagris gallopavo (Wild turkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Meleagridinae> Meleagris.
Aromaticity0.10
Grand average of hydropathy-0.035
Instability index46.70
Isoelectric point7.20
Molecular weight157230.76
Publications
PubMed=20838655

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27765
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     237.64|      99|     907|     299|     399|       2
---------------------------------------------------------------------------
  222-  366 (147.75/88.32)	CGRCSLLPVVNN..SGAMCNSwkldpttlrfPLKGLLPYDKdLF...........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................epqtallryvleqpysrdmvcnmlglnkqhkqrcpVLEDQLVDLVVYAMERSETE...EKFD..DG............................GTSQLLWQHLSSQLIFFV..LFQFASFPHMV...LSLHQKLAGRGLI
  367-  399 (20.50/11.51)	KGRDHLMWVLLQfiSGSIQKN..........ALADFLPVMK.LF........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1166- 1271 (69.39/36.99)	............................................dllypekecipvpdinkpqsthafamtciwihlnrkahsdnsklqipiphslkhhheflqqslrnkslqmndykiallcnaystnsecftlpmgvlvetiygngnmrislpgtncmasgsitplpmnlldsltvhakmslihsiatrviklahakssvalapalvetysrllvymeieslgikgfisqllptvfkshawgilhtllemfsyrmhhiqphyrvqllshlhslaavpqrnqnqlhlcvestalrlitalgssevqpqftrflsdpksvlsaeseelnraliltlarathvtdfftgsdsiqgtwckdilqtimsftphnwashtlscfpaplqvffkqnnvpqesrfnlkknveeeyrkwksmtneneiitrfsvqgspplflcllwkmlletdhinqigysdrvlerigaralvahvrtfadflvyefstsaggqqlnkcieilndmvwkynivtldrlilclamrshegneaqvcyfiiqllllkpndfrnrvsdfvkenspehwlqndwhtkhmsyhkkypeklyfeglaeqvnppvqiqpqylpiyfgnvclrflpvfdivihrflellpvsksletlldhlgglykfhdrpvtylyntlhyyerhlrertnlkrklvhaiigslkdnrplgwclsdtylkcamnarednpwvpddtyyckligrlslspmagkspgpfpncdwrfnefpnpaahalhvtcvelmalavpgtdvgnallnvvlksqplvprenitawmnaigliitalpepywiVLHDHIVNVINSPSLTSETEwvgYPFQlfDFtachqsysemscsytlalahavwhhssiGQLSLIPKFLTEVLIPIVktEFQLLYVYHLVgpfLQRFQQERTRCMI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     158.05|      41|     787|     174|     214|       3
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  174-  214 (76.01/48.30)	NACL..LPAY.FAVTEIRKLYPEGKLPHWLLGNL..VSDFVDTFRP
  933-  955 (29.28/13.73)	..................KLYFEG.LAEQV..NP..PVQIQPQYLP
  960- 1003 (52.76/31.10)	NVCLrfLPVFdIVIHRFLELLPVSKSLETLLDHLggLYKFHD..RP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.83|      32|     263|    1043|    1111|       4
---------------------------------------------------------------------------
 1079- 1111 (59.18/85.44)	LSPmAGKSPGPFPNCDWRFNEFPNPAAHALHVT
 1341- 1372 (57.65/18.48)	MEP.AGVSQQPLSNGSPAQQPSQVPVNVALPVT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.00|      24|     263|     518|     573|       5
---------------------------------------------------------------------------
  546-  573 (33.95/66.44)	RVIKLAHAKSSValapALVETYSRLLVY
  811-  834 (41.05/12.06)	RVLERIGARALV....AHVRTFADFLVY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     136.58|      36|      84|     509|     544|       6
---------------------------------------------------------------------------
  433-  475 (36.59/18.75)	....NRKAHSDNSKLQIP.IPHSLKHHHEF.LQQSlrnkslqmndykIA
  476-  507 (39.73/21.00)	LLCNAYSTNSECFTLPMGvLVETIYGNGNMRI.................
  509-  544 (60.25/35.74)	LPGTNCMASGSITPLPMN.LLDSLTVHAKMSLIHS............IA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.88|      16|     262|     776|     792|       9
---------------------------------------------------------------------------
   63-   83 (22.99/ 8.64)	IVRFiHSQHSPKrisfLYDCL
  777-  792 (31.89/16.99)	ITRF.SVQGSPP....LFLCL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.14|      14|      16|    1044|    1058|      11
---------------------------------------------------------------------------
 1044- 1058 (25.22/19.89)	WCLSDTYLkCAMNAR
 1063- 1076 (29.93/18.78)	WVPDDTYY.CKLIGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.86|      19|     461|     117|     143|      14
---------------------------------------------------------------------------
  117-  137 (27.81/37.98)	LTFKLIRKIIGGVdyKGVRDL
 1024- 1042 (33.05/18.09)	LKRKLVHAIIGSL..KDNRPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.46|      22|     859|     268|     289|      20
---------------------------------------------------------------------------
  268-  289 (41.84/31.56)	ALLRYVLE.QP.YSRDMVC...NMLGL
 1128- 1154 (24.62/15.10)	ALLNVVLKsQPlVPRENITawmNAIGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.99|      16|     696|      39|      56|      22
---------------------------------------------------------------------------
   39-   56 (24.87/22.75)	SCLSA.....FRQfwSSLSQESH
  733-  753 (26.12/14.53)	SCFPAplqvfFKQ..NNVPQESR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27765 with Med23 domain of Kingdom Metazoa
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