<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27760

Description Mediator complex subunit 12 like
SequenceQDELTAVNVKQGFSNQPAFSGDEHGSARNVVINASKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHNWFTDLAGSKPLTILAKKVPILSKKEDVFAYLAKYSVPLLRAAWLVKMTCAYYAAISEAKIKKRQATDPNTEWTQVITRYLREQLAKVAEFYHVTSSQGNSSVVMPQEMEQALKQWEYNEKLSFYMFQEGMLERHEYLTWILDVLEKIRPADDDILKLVLPLVLQYSEEFVQSAYLSRRLAYFCARRLSLLLSDGASLAAAHSPHMIIAPSNPALAAPSPTAPGPVLSPVQLSCSDFLSCPQHRPLVYGLSCMLQTITLCCPSALVWNYSTNENKNVNPGSPLDLLQVAPSSLPMPGGNSTFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESAAGVTISRVLHTLEVLDRHCFDRSDSSNSMETLYHKIFWANQNKDNQEAAPSDEAVVMLLCEWAVSCKRSGKHRAMVVAKLLEKRQAEIEAERCGESEVLDEKESLSSASLTSSSLPVFQNVLLRFLDTQAPSLSDPNSDHEKTEFVNLVLLFSEFTRHDVFSHDAYMCTLISRGDLSITATTRPRSPNGETVDEHYSKENDVKIEDHSIMEHMGTDSGPTSIFDDVDKGDFKIFSPMPGESCESMNSSLDRRISVASEKSVKRERLREAIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRMILLYGVGKERDEARHQLRKITKDILKILNKKSTTETGALMPLKRLREEGFYVIIIGDEGQKARKNKQEAFPTLETVFTKLQQLSYFDQHQVTSQISSNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHACLILNSEQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSAHSINYSMLGKILSDNAANRYSFVCNALMNVCMGHQDAGRINDIANLCAELTACCTVLSSEWLGVVKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDPDAEPGARMTCRLLLHLFRTPQVCLFPQGAGKLPPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAILMLGDAEIGSSSVTPVKNEELPVRGLLDEIPEDEMWASSHALKSRGKAVSIETASLSEYARYVLRSICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGVKECSEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCTKEPGSGSVAEMNSLLDNIAKATIEVFQQSADQFGIVAASTGCKTARILWLKQACSISSSSEWRGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQGDVKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQTNNELFTTVLDMLGVLINGTLASDLSSASQGGPEENKRAYMNLVKKLKKELGDKRSDSIDKVRQLLPLPKQTCDIITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGHKNPAPLSWAWFGTVRVDRKVIKYEEQQHLLLYHAHPKPKPRSYYLEPLPLPPEEEEEEPTTPVSQEPERKSGELSDQGKLATDDEKKTKGRKRKSKSSSKADEYPPNSLYRVPPNYSPIPSQMMQHPHSALWGYTIMGQPQQPGFFAQNQPLPPGGSRLDPTSSFVPANTKQALSNMLQRRSVLQPPSLHAVTPQQQLLQMKLLQQEQQQRLLRHQAQARSLQQAAQGRALLEELEILSLFLLCTAGMPHGYTMYSTPMPLQQQQPGSVVLSPGYTPRAYTAHSSPVLMERLRPGQPGGVAQQQAAAYMQPLTGAQRLTHQPLQPNSLIGAGLDSTSTTRTHPSLSSAQLPQEQMRQRQQQIRQQRLFQVQQGQQQQTLDLQPVQPQQPLRNQKAACSFSQYSCLEQAASDGLPQKQSSARHPXQAPAPPAAEHSIDGQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQGVNQYGHP
Length2163
PositionKinase
OrganismMeleagris gallopavo (Wild turkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Meleagridinae> Meleagris.
Aromaticity0.07
Grand average of hydropathy-0.362
Instability index56.76
Isoelectric point6.90
Molecular weight241254.29
Publications
PubMed=20838655

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro
transcription factor binding	GO:0008134	IEA:Ensembl

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27760
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     143.53|      29|      31|    1860|    1888|       1
---------------------------------------------------------------------------
 1806- 1841 (28.39/10.34)	QMM.....QHpHSALwgytimgQPqqPGFFA...QNQPLPPGGS
 1860- 1888 (50.94/24.95)	NML.....QR.RSVL.......QP..PSLHAVTPQQQLLQMKLL
 1894- 1927 (25.96/ 8.76)	QRLlrhqaQA.RSLQ.......QA..AQGRALLEELEILSLFLL
 1970- 1996 (38.23/16.71)	PVL.....ME.R..L.......RP..GQPGGVAQQQAAAYMQPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     664.70|     158|     165|    1293|    1454|       2
---------------------------------------------------------------------------
 1057- 1173 (133.44/79.67)	.................................................LSSEWLG...VVKAlCC...SSNHVWGFN.......DLLCSVDVSDLS.FHDSLATFIAILIARQCfsledvvqHV...............ALPSLLAAACG.DPDA............E.PGAR.MTCRLLLHLFRTPQVCLFPQGAGKLPPG....IRSSCDR.
 1174- 1289 (101.20/58.44)	....HLL...A.AA..HNSIEV....GAVFAVLKAI......................LMLGD...AEIGSSSVTPVKneelpvrGLLDEIPEDEM............WASSHAL........KSrgkavsietaslseyARYV.LRSIC....QQ............EWVGEHcLKEP..ERLCTD.KDLILDP....................
 1294- 1454 (256.22/168.67)	KQAQKLLQLIC.YP..HGVKECSEGDNPQRQHIKRILQN.....LDQWtLRQSWLElqLMIKQ.CTKEPGSGSVAEMN.......SLLDNIAKATIEVFQQSADQFGIVAASTGC........KT...............ARILWLKQACSISSSS............EWRGVW.LVAPLIAKLPTSVQGRVLKAAGEELEKGQH..LGSSSKKE
 1457- 1613 (173.84/108.50)	RQKQKSMSLLSqQPflSLVLTCLKGQDEQREGLLTSLQNqvnqiLSNW..RE...............ERYQGDV.KAR.......QMMHEALQLRLNLV...GGMFDTVQRSTQW........TT...............DWALLLLQIITSGTVDmqtnnelfttvlDMLGVL.INGTLASDLSSASQG......GPEENKRAYmnLVKKLKKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.01|      26|     165|     298|     329|       3
---------------------------------------------------------------------------
  298-  329 (45.31/34.91)	AAPSPTApgpvlsPVQLSCSDFLSCP...QHRPLV
  467-  495 (44.70/22.22)	AAPSDEA......VVMLLCEWAVSCKrsgKHRAMV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.82|      13|     165|    1790|    1802|       4
---------------------------------------------------------------------------
 1724- 1735 (22.56/12.53)	PRS.YYLEPLPLP
 1736- 1746 (17.41/ 7.61)	PEEEEEEPT..TP
 1790- 1802 (25.85/15.66)	PNSLYRVPPNYSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     187.65|      46|      55|    2060|    2107|       5
---------------------------------------------------------------------------
 2000- 2027 (41.14/18.35)	.QRLTHQ.PLQPNS................LIGA...GLDSTSTTRTHP
 2060- 2107 (75.91/47.06)	QQTLDLQ.PVQPQQPLRNQKAACSFSQYscLEQAASDGLPQKQSSARHP
 2117- 2163 (70.61/37.41)	EHSIDGQfPRQGLQQTQQQQQTAALVRQ..LQKQLSSNQPQGVNQYGHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.09|      66|     277|     660|     735|       6
---------------------------------------------------------------------------
  660-  735 (95.95/96.79)	SCESMNSSLDRRISVASEKsVKrERLREAIFPSNYDLLRHLQYATHFpipLDESSSHECNQRMIllygvGK.ERDEA
  950- 1016 (115.14/80.74)	SCSHLRSKFGDLFSSACSK.VK.QTIYSNVQPSNSNLLWDPEFMLDF...IENPSAHSINYSML.....GKiLSDNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.22|      10|     167|    1615|    1624|      11
---------------------------------------------------------------------------
 1615- 1624 (19.20/12.20)	GDKRS..DSIDK
 1652- 1663 (14.02/ 6.86)	GNKIAgfDSIDK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27760 with Med12 domain of Kingdom Metazoa
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