<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27759

Description Mediator of RNA polymerase II transcription subunit 13
SequenceLFSLAELTGIKWRRYNFEGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVDVIHRELHMVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFIRPYDKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPSPFQVLVSPYGLNGTLTGQSYKMSDPATRKLMEEWQYFYPMVLKKKEGMKEEEELGYDNDFPVAVEVIVGGVRMVYPSAFVLISQSDIPMSQNAASAGGHINVGQQGLGSVKDPSSTCGMPLTPPTSPEQAVMGESGCSQSSISHSAVQEGTVSVHSPKKSSKITPKFHNRMVHRVWKECILNRSQSKRSQITTANLEEEVPNNTVSWDFVDPVQRVSCSCSRHKVFKQRCAAGSGRPPMINQPGFSVGTSSSSSLPPPASSKHKATERQDKGEKLQKRPMMPFHHRPSVTEELCVEQDTSGQKLGLAGMEPSLEVPNSRKYEKPLSIPARNPSKQINMNPMDSPHSPSSPLPPTLSPQPRGQEAENLDPPSVPVNPALYGSGLELQPLPSLDERTVLVGQRLPLMAEVSETALYCGIIQNNESLDMWRTYSVPSSDDPEFRPPGLPCERDDVKMEVNSESTAVKRLLAQPNKRFKILEEQKPVQTLSYLDPLPLIQQPGEGLGDASDPYTFEDGDIKYSFTGNKKCKLVAEKDLLKKNKSEDGIGTKEIPTTGHSTPVPDGKDAMSIFSSAPKADTRQDNAAGRVGSGSLTQVTDLAPSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMSYKDGISSETVTTLGMMESPMVSMVPTQLAEFKMEVEDGLGSPKPEEIKDFSYVHKVPSFQPFVGSSVFAPLKILPSQCLLPLKIPDACVFRPSWAVPPKIEQLPLPPATFIRDGYNNVPSVGSLADQDYLQMNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQPIPEAHSLYVTLILSDSVLNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFIEDELDIFGKTSDIGQAAERRLMICQSNLISQMGEGARRTQEPPMSLLLLLQNQHTQPFTSLSCLDYMSSNNRQTLPCMNWSYDRLQADSNDSWIECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLDGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWGTEECDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLLPPKYQTPAPASQTQTIPGSTGPVPSNSTCLSTSGAPPTGSSFNSTPNSGTTSLPAGSSSSSGSSVPQLSASSATPGVNQMSATPTPGFSGNIGSGQNTSTGGSAADRSQGSTGPGGDTEAGQSLSQQQQEGQEGVTERERIGIPTEPESADSNAYPPAVVIYMVDPFTYTADEESASTNFWLLSLMRCYTEMLDNLPENMRNSFILQIVPCQYMLQTMKDEQVFYIQHLKSLAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIDLPNRSRRSKLSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKQLKEVCRMCGISSADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNLQSSQLNTPQDASCTHILVFPTSATIQVAPANYPNEDGFSPTNDDMFDLPFPDDMDNDIRILITGNLHSSPNSSPVPSPGSPSGIGVGSHYQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISIAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRSSCLPVHFVVLTQLYNAIMNIL
Length2196
PositionMiddle
OrganismMeleagris gallopavo (Wild turkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Meleagridinae> Meleagris.
Aromaticity0.07
Grand average of hydropathy-0.380
Instability index59.92
Isoelectric point5.58
Molecular weight241491.84
Publications
PubMed=20838655

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP27759
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.94|      14|      19|    1595|    1612|       1
---------------------------------------------------------------------------
 1595- 1608 (26.23/18.52)	GNIGSGQNTSTGGS
 1615- 1628 (26.72/ 8.96)	GSTGPGGDTEAGQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.75|      18|      18|     941|     958|       2
---------------------------------------------------------------------------
  941-  958 (35.83/17.91)	PLKIPDACVFRPSWAVPP
  962-  979 (33.92/16.56)	QLPLPPATFIRDGYNNVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.05|      19|      20|    1533|    1552|       3
---------------------------------------------------------------------------
 1533- 1551 (36.17/14.08)	TCLSTSGAPPTGSSFNSTP
 1556- 1571 (26.50/ 8.12)	TSLPAGSSSSSGS...SVP
 1573- 1589 (24.38/ 8.64)	..LSASSATPGVNQMSATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     130.89|      42|      97|     297|     347|       4
---------------------------------------------------------------------------
  297-  314 (24.57/15.35)	................................DPSSTCGMPLTPPTS..PEQ
  324-  347 (28.39/ 6.09)	QSSISH.SAVQEGTVSVHS..PKKSSK.........................
  422-  447 (30.01/ 7.00)	PPMINQ.PGFSVGTSSSSSlpPPASSK.........................
  846-  887 (47.91/14.86)	PPSLEQhPAFS..........PVMSYKdgissETVTTLGMMESPMVSmvPTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     358.33|     113|     431|    1630|    1759|       5
---------------------------------------------------------------------------
 1164- 1207 (38.70/13.65)	........................................DIFGKTSDIGQAAER....RLMICQSNLISQ..............................MGEGARRT...QEPPMSLLL............................................
 1630- 1759 (172.44/144.89)	SQQQQEGQEGvterERIGIPTEPESADSNaypPAVVIYmvDPFTYTADEESASTNFWllSLMRCYTEMLDN..............................LPENMRNSfilQIVPCQYMLQTMKDEQVFYIQHLKSLAFsVYC....QCRRP.LPtqIHIKSLT
 2055- 2186 (147.19/86.45)	SHYQHSRSQG....ERLLSREAPEELKQQ...PLALGY....FVSTAKAENLPQWFW..............sscpqaqnqcplflkaslhhhisiaqtdelLP..ARNS...QRVPHPLDSKTTSDVLRFVLEQYNALSW.LTCnpatQDRSScLP..VHFVVLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.24|      37|     431|     173|     246|       7
---------------------------------------------------------------------------
  195-  242 (52.64/65.55)	GLngtltGQSykmSDPATrklMEEWQYFYPMVLKKKEGMKEEEELGYD
  686-  722 (65.60/22.86)	GL.....GDA...SDPYT...FEDGDIKYSFTGNKKCKLVAEKDLLKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.24|      28|      32|     999|    1030|      10
---------------------------------------------------------------------------
  999- 1019 (22.27/10.30)	............TPVTlnSTAPASNSGAGVLPS
 1020- 1043 (29.30/14.97)	PatPRFSVPTPrTPRT.....PRTPRGGG....
 1506- 1530 (43.67/18.91)	P..PKYQTPAPaS.QT..QTIPGS...TGPVPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.83|      41|     477|     571|     619|      11
---------------------------------------------------------------------------
  571-  619 (59.17/58.66)	QPLPSLDERTVlvgQRLPlmaEVSetALYCGIIQNNESLDMWRTYSVPS
 1069- 1109 (70.66/45.29)	RPLNSVEPATV...QPIP...EAH..SLYVTLILSDSVLNIFKDRNFDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.60|      32|    1266|     136|     169|      13
---------------------------------------------------------------------------
  136-  169 (52.27/50.56)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1405- 1436 (59.33/46.02)	PENEA.LLDGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.88|      31|      37|      12|      45|      14
---------------------------------------------------------------------------
   12-   45 (55.03/48.53)	WRRynfEGHGDCGPIISAPAQDDPILLSFI.RCLQ
   52-   83 (58.85/41.41)	WRR...DVKPDCKELWIFWWGDEPNLVDVIhRELH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.38|      20|      28|    1111|    1130|      16
---------------------------------------------------------------------------
 1111- 1130 (40.85/23.23)	CICACNMNIK.GADVGLYIPD
 1141- 1161 (34.53/18.61)	CGFSAIMNRKlGYNSGLFIED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.57|      27|      27|    1845|    1871|      17
---------------------------------------------------------------------------
 1845- 1871 (47.29/29.94)	IDLPNRSRRSKLS.ARKIGLQKLWEWCI
 1874- 1901 (43.27/26.71)	VQMTSLPWRVVIGrLGRLGHGELKDWSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.21|      12|      17|    1210|    1221|      26
---------------------------------------------------------------------------
 1210- 1221 (22.19/12.50)	QNQHTQPFTSLS
 1229- 1240 (25.01/15.18)	NNRQTLPCMNWS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27759 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APSLHDLDNIFDNSDEDELGAVSPALRSSKMPAVGSEERPVGKDGRTAVPYPPTVADLQRMFPTPPSLE
2) CAAGSGRPPMINQPGFSVGTSSSSSLPPPASSKHKATERQDKGEKLQKRPMMPFHHRPSVTEELCVEQDTSGQKLGLAGMEPSLEVPNSRKYEKPLSIPARNPSKQINMNPMDSPHSPSSPLPPTLSPQPRGQEAENLDPPSVPVNPALYGSGLELQ
3) GSLADQDYLQMNTPQMNTPVTLNSTAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATVQ
4) KDPSSTCGMPLTPPTSPEQAVMGESGCSQS
5) KSEDGIGTKEIPTTGHSTPVPDGKDAMSIFSSAPKADTRQDNAAGRVGSGSLTQVTD
6) MWRTYSVPSSDDPEFRPPGLPCERDDVKMEV
7) NLHSSPNSSPVPSPGSPSGIGVGSHYQHSRSQGERLLSREAPE
8) PPKYQTPAPASQTQTIPGSTGPVPSNSTCLSTSGAPPTGSSFNSTPNSGTTSLPAGSSSSSGSSVPQLSASSATPGVNQMSATPTPGFSGNIGSGQNTSTGGSAADRSQGSTGPGGDTEAGQSLSQQQQEGQEGVTERERIGIPTEPESA
782
415
982
296
724
611
2032
1506
850
571
1080
325
780
641
2074
1655










Molecular Recognition Features






MoRF SequenceStartStop




NANANA