<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27755

Description Mediator complex subunit 12
SequenceVMRTFLPCSFLQYSGEFVQSAYLSRRLAYFCTRRLAMQLDGAGGHPPHILSTQTGNALPSTPTPQPATGNPPPSPFSDLLLCPQHRPVVYGLSCILQSIILCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPGGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQETTAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLYNRIFGLGPTKDSHEISPDDDAVVALLCEWAVSYKRSGRHRAMVVAKLLEKRQAEIEAERCGDSEVVDEKGSISSGSLSAASAPVFQDVLMQFLDTQAPMLTDPGKENEKVEFFNLVLLFCELIRHDVFSHNIYMCTLISRGDLAMDSHGPRPPSPFDDPAEEHDRKETEGNSGIKLEDTGLSEPMDIDHNSSTIFDDMEKTDFSMFSPPMHCESKASPSPEKPDPEKEAKPLLKDKSAEGMLASLYDQPRHIQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHTIKKITKDILKVLNRKSTAETEEQLLLPLINPVLSTFVGGEEGQKRKKSKPEAFPTAEDIFAKFQHLSHFDQHQVTSQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLNISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHSCLILNQDQMAQVFEGQSVWVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSDSNMLWEPEFMIDTIENPSAHNFTYTNLGKSLNENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQQDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFSHPGGVDDLMDDELGTRKAGGRVVTVETASLDIYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSTQAQRLMQLICYPHRLLDNEEGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTANNEMNSLLENIAKATIEVFQQSAETSSASSAGNGVNNISSSASATPASNKSKPILSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWDLFEGLKHSAPLSWGWFGTVRVDRRVSRFEEQQRLLLYHTHLKPKPRSYYLEPLPLPPEEEEPPTPVALEPEKKAVEPSKADKTSSNPATSTEERKKKQSKTKKRNQSASKSEDFVLGPSRGVSYGVGMPTDLLHHQAGSTMSRLAYGQSPVGLYAQNQPLPAGGPRLDTSYRPVRMPLGKLVQSRPPYSGVLPSGMGSMMGIDPSYKPAVYRQQPPVSQGQILRQQLQAKLQGQGIMGQQPVRQMAPTPSYGALQPSQGYTPYVSHIGLQQHPSQSGTMVPPTYSGQPYQNSHPSSNPALVDPVRQMQQRPSGYVHQQAPGYGHTLGNTQRFPHQSIQQAPMMTGMNHLGPQGVPSGIRPSQILPELQKCMELKEKHKNRKLEVTWLEHCTQFYLHPFTKVQHHREWQRRTLEKENEQNFSTSDFLKTNTHKNNLQPQVSTVPQPQAQGQPPFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQQNNNPFGRY
Length1919
PositionKinase
OrganismMeleagris gallopavo (Wild turkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Meleagridinae> Meleagris.
Aromaticity0.07
Grand average of hydropathy-0.452
Instability index52.96
Isoelectric point6.52
Molecular weight213941.48
Publications
PubMed=20838655

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
chromatin binding	GO:0003682	IEA:Ensembl
protein C-terminus binding	GO:0008022	IEA:Ensembl
protein domain specific binding	GO:0019904	IEA:Ensembl
RNA polymerase II cis-regulatory region sequence-specific DNA binding	GO:0000978	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
axis elongation involved in somitogenesis	GO:0090245	IEA:Ensembl
canonical Wnt signaling pathway	GO:0060070	IEA:Ensembl
embryonic brain development	GO:1990403	IEA:Ensembl
embryonic neurocranium morphogenesis	GO:0048702	IEA:Ensembl
endoderm development	GO:0007492	IEA:Ensembl
heart development	GO:0007507	IEA:Ensembl
neural tube closure	GO:0001843	IEA:Ensembl
oligodendrocyte development	GO:0014003	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
post-anal tail morphogenesis	GO:0036342	IEA:Ensembl
Schwann cell development	GO:0014044	IEA:Ensembl
spinal cord development	GO:0021510	IEA:Ensembl
stem cell population maintenance	GO:0019827	IEA:Ensembl
Wnt signaling pathway, planar cell polarity pathway	GO:0060071	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27755
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     236.86|      56|     236|    1633|    1689|       1
---------------------------------------------------------------------------
   58-   91 (23.75/ 6.25)	.........................LPSTPT.PQPATGNpppSPF.SD..LLLCPQHrPVVYG.....
 1573- 1620 (41.21/14.95)	............GQSPVglyAQNQPLPAGGPrLDTS..Y...RPVrMPlgKLVQSRP.PYS.G.VLPS
 1621- 1651 (43.54/20.38)	......GMGsMMGIDP.....................S......Y.KP..AVYRQQP.PVSQGQILRQ
 1653- 1704 (88.25/47.98)	LQAKLQGQG.IMGQQPV...RQMAPTPSYGA.LQPSQGY...TPY.VS..HIGLQQH.PSQSGT....
 1884- 1916 (40.11/16.83)	LQQTQQQQQ.TAAL..V...RQL..QQQLSN.TQPQQNN...NPF.......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.86|      15|      19|    1397|    1415|       2
---------------------------------------------------------------------------
 1397- 1415 (14.83/25.46)	TKgNKIAGFDsIFkkEGLQ
 1418- 1432 (30.03/20.27)	TK.QKISPWD.LF..EGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.36|      13|     231|    1542|    1559|       3
---------------------------------------------------------------------------
 1542- 1556 (17.86/19.90)	LGPsRGVSYGVgMPT
 1775- 1787 (26.50/ 8.92)	LGP.QGVPSGI.RPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     331.78|      97|     238|      99|     202|       5
---------------------------------------------------------------------------
   99-  202 (149.39/108.80)	IILCcpsALVWHYSLT.DSR.IKTGSPLDHlPIAPSNLPMPGGNSAFTQQvRAKLREiEQQIKERGQAVEVRWsFDKC.QETTAGFTI.GRVLH.......TLEVLDSHSFERSD
  343-  435 (147.18/84.49)	IYMC...TLISRGDLAmDSHgPRPPSPFDD.PAEEHDRKETEGNSGIKLE.DTGLSE.PMDIDHNSSTI.....FDDM.EKT..DFSMfSPPMH.......C.ESKASPSPEKPD
 1802- 1850 (35.21/12.75)	..............................................................KHKNRKLEVTW.LEHCtQFYLHPFT...KVQHhrewqrrTLEKENEQNFSTSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.04|      32|     545|     228|     259|       6
---------------------------------------------------------------------------
  228-  259 (56.36/41.58)	PDDDAVVALLCEWAVSYKRSGRHRAMVVAKLL
  800-  831 (54.67/40.09)	PDRVNDIAILCAELTGYCKSLSAEWLGVLKAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.57|      11|     111|     734|     744|       7
---------------------------------------------------------------------------
  734-  744 (22.58/15.47)	NTIYCNVEPSD
  843-  853 (20.99/13.81)	NDLLCNVDVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.72|      18|      23|    1732|    1750|      13
---------------------------------------------------------------------------
 1732- 1750 (32.42/26.14)	QMQQRPSGYVhQQAP...GYGH
 1754- 1774 (31.30/19.04)	NTQRFPHQSI.QQAPmmtGMNH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.24|      21|      24|    1289|    1311|      14
---------------------------------------------------------------------------
 1289- 1311 (30.70/27.92)	QQTTewAVL.LLDIISSGTV..DMQS
 1314- 1337 (26.54/15.43)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.74|      18|     540|     444|     475|      20
---------------------------------------------------------------------------
  446-  463 (33.70/39.68)	DKSAEGMLASLYDQPRHI
 1230- 1247 (32.03/ 6.51)	DEQREGLLTSLYSQVQQI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27755 with Med12 domain of Kingdom Metazoa
Unable to open file!