<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27754

Description Mediator of RNA polymerase II transcription subunit 15
SequenceDEAMRKAGVAHNKSSKDMESHVFMKAKTREEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQNLTGGPPAGAPGMTIASRAQGAPMSGMGGLGPMGQQMSLPGQQQPPGSTGMAPHGMPGVSTATQQTQLQLQQIKLQMQQQQNQQQVAQAQQSQLPPQSQPQPQPMVSQAQAISGQIPGQVMPVTLTPQQLKAMQYREEVARSHSVGTQPMTRLFQILKVRAQLVQQQHAAAAAVQAAQAQAAQMGASAQVRALEPVSPYCESLPALLTHMCSTFHLHVPTIKNARKQQVQDSNCCIPPQHFYQTAHLASYSVASPALMLIKLTVREQLTNLPFMLPLPLIPGGCMCFSSCQCTAFLVLRLLLSVVPLSSKMITAPMARGGMQIRPRFPPTTAVSATPPSSIPMGGQQMPQVSQNSITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPNSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFMPAMTAIHGPPITAPVISSRKRKYEEDDRQTIPNVLQGEVARLNPKFLVNLDPSHCSNNGTVHLICKLDDKNLPNVPPLQLSVPADYPDQSPLWIKNPRQYAANPFLQSVYRYMTSKLLQLPDKHSVTALLNTWAQSIRQACLSAA
Length779
PositionTail
OrganismMeleagris gallopavo (Wild turkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Meleagridinae> Meleagris.
Aromaticity0.04
Grand average of hydropathy-0.411
Instability index72.09
Isoelectric point9.64
Molecular weight84708.84
Publications
PubMed=20838655

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27754
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     123.47|      28|      28|     441|     468|       1
---------------------------------------------------------------------------
  388-  416 (42.48/12.31)	PRFPPTTAVSATPPSSI......PMgGQQMPQVSQ
  434-  451 (35.42/ 8.92)	PQSMPP................pPQ.PQPSPQPGQ
  452-  481 (45.56/13.79)	PNSQPNSNVSSGPAPSPssflpsP.....SPQPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     168.93|      36|      36|      58|      93|       2
---------------------------------------------------------------------------
   58-   87 (48.86/17.24)	....................................P.................MNAL.......QNLTG.GPPAGAPGMTIASRAQGAPM
   88-  116 (39.53/12.37)	SGM..GGL...........................gP.................MGQQ.......MSLPGqQQPPGSTGM........AP.
  117-  168 (51.50/18.62)	HGM..PGV.............................statqqtqlqlqqiklqMQQQ.......QNQQQ.VAQAQQSQLPPQSQPQPQPM
  176-  247 (29.03/ 6.88)	SGQipGQVmpvtltpqqlkamqyreevarshsvgtqP.................MTRLfqilkvrAQLVQ.QQHAAAAAVQ.AAQAQAAQM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.53|      14|      22|     673|     686|       3
---------------------------------------------------------------------------
  673-  686 (24.62/13.29)	VARLNPKFLVNLDP
  698-  711 (26.92/15.20)	ICKLDDKNLPNVPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.68|      15|      22|     330|     351|       4
---------------------------------------------------------------------------
  330-  344 (27.82/16.53)	QLTN.LPFMLPLPLIP
  354-  369 (18.87/ 7.01)	QCTAfLVLRLLLSVVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.91|      23|      28|     554|     580|       5
---------------------------------------------------------------------------
  545-  572 (35.21/19.18)	DKNEdrkkdLSKMKSLLDILTDPSKRCP
  577-  601 (39.70/14.70)	QKCE...iaLEKLKNDMAVPTPPPPPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.06|      39|     219|     491|     530|       6
---------------------------------------------------------------------------
  491-  530 (65.65/31.41)	NFSVPSPGPLNTP...GNPNSvMSPASSSQSEEQQYLEKLKQL
  713-  754 (65.41/28.10)	QLSVPADYPDQSPlwiKNPRQ.YAANPFLQSVYRYMTSKLLQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.57|      14|      22|     611|     624|      11
---------------------------------------------------------------------------
  611-  624 (23.65/12.87)	PLLDAVLA.NIRSPV
  635-  649 (21.91/11.41)	PAMTAIHGpPITAPV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27754 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APMARGGMQIRPRFPPTTAVSATPPSSIPMGGQQMPQVSQNSITMMSSPSPVQQAQTPQSMPPPPQPQPSPQPGQPNSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPAAARTPQNFSVPSPGPLNTPGNPNSVMSPASSSQSEEQQYLEKLKQLS
2) HNKKSQASVSDPMNALQNLTGGPPAGAPGMTIASRAQGAPMSGMGGLGPMGQQMSLPGQQQPPGSTGMAPHGMPGVSTATQQTQLQLQQIKLQMQQQQNQQQVAQAQQSQLPPQSQPQPQPMVSQAQAIS
377
47
531
176










Molecular Recognition Features






MoRF SequenceStartStop




NANANA