<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27753

Description Mediator of RNA polymerase II transcription subunit 13
SequenceADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLSVWRRDQRPGRRELWIFWWGDDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEISQHQPVYLLSEEHLTLAQQSNSPFQVILSPFGLNGTLTGQSFKLSDSSTKKLIGEWKQFYPVTSNLKEGSEEKQEDMDWEDDSLAAVEVLVAGVRMVYPACFVLVPQTDIPPPSTVGTSHCSTTCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDAQSAQKWVKFSSVSDGFISDSTSHHGGKIPRKLANQVVDRVWQECNMNRTQNKRKYSATSNSLCDEETADKVASWDFVEATQRTNCNCSRHKNLKPRNSGQQGQAPPVGQQQQAAPKHKTNEKQDKGDKPQKRPLTPFHHRVSISDDVAMEADSASQRLVMTAPDSQVRFSNIRTNDVAKTPQMHNAEMHNAEMANSPQPPPLSPHPCDVVDEGVTKAPSTPQSQHFYQMPTPDPLVPAKAMEDRLDGLSQPFPAQFPEVIEPTMYIGTAVNLEEDEADTTWKYYKVPKKKDMEFLPPQLPNDKLRDDPVIPAGQENITSVTELMVQCRKPLKVSDELVQQYQSKNQYLAAVVSEADQEPEIDPYAFVEGDVEFLFPDSKKDRQNIERETGKKHKAEDGTSGVTVLSHEGEDAMSLFSPSVKQDAQRIAAHARTASTSLIHETDLVVSYTDLDNLFNSDEDELTPGSKRTVNGADDKSNCKEAKAGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTLGGTVLEGNSSSMGAQFRIEVDEGFCSPKPAEIKDYSYVYKPENCQALVGCSMFAPLKTLPSQCLPPIKLPEECIYRQSWTVGKLDLLPPGPAMPFIKDGDGSTMDQEYGPAYTPQTHTPFGMPPGSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNSSGLFLEDELDILGRNTECGKEAEKRFEALRATAVEHGSAGLKEPEKLPDELILLLQDQCTNLFSPFGAADQDPIPKVGAVSNLVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKTTCLHHWSKRNVVDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRSWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWERLMLEPYGSQRDVAYVVVCPENEALLNGAKSFFRDLTAIYESCRLGQHRPICKLLPDGIMRVGPTASKKLSEKLVTEWFSQTANANSEAFSKLKLYAQVCRYELGPYLASQPLDNSLLAQTNLVPPSSQPASALPPVTASTGNPNTPSAPAASTSSTMTATSNSAMSSAATTANSTLTTTATSSSSANIGSGIPTNKPSSFPPFSSMNNTTSASLPSQAATVQNGQTGGQQQQPVLQTAGMSGDATTAPAQPHPEVSESTMDRDKVGVPTDGDSHAITYPPAIVVYIIDPFTYEKKDENSSSSSLWTLGLLRCFLEMVQVLPPNIKNIISVQIVPCQYLLQPVKHEDRQIYTQHLKSLAFSAFTQCRRPLPSSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWLLASCTDLYGEQLETCIINIDVPNRARRKKGSARRLGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFIIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASSTYTTENLDLAFNTNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDMGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQNQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPATQDRRSCLPIHFVVLNQLYNFIMNML
Length2161
PositionMiddle
OrganismMeleagris gallopavo (Wild turkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Meleagridinae> Meleagris.
Aromaticity0.07
Grand average of hydropathy-0.417
Instability index51.56
Isoelectric point5.42
Molecular weight237829.78
Publications
PubMed=20838655

Function

Annotated function Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
cholesterol homeostasis	GO:0042632	IEA:Ensembl
negative regulation of DNA-binding transcription factor activity	GO:0043433	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
triglyceride homeostasis	GO:0070328	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27753
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     233.36|      52|      67|     432|     484|       1
---------------------------------------------------------------------------
  432-  484 (85.88/47.79)	PKHKTNEKQDK..GDKPQKRPLTPfHHRVSIS....DDVAMEADSA..SQRLV.MTAPDSQV
  498-  553 (75.55/37.75)	PQMHNAEMHNAemANSPQPPPLSP..HPCDVV....DEGVTKAPSTpqSQHFYqMPTPDPLV
 1577- 1627 (71.93/35.57)	PVLQTAGM..S..GDATTA.PAQP.HPEVSEStmdrDKVGVPTDGD..SH..A.ITYPPAIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.03|      65|      67|     904|     969|       3
---------------------------------------------------------------------------
  904-  969 (120.48/64.13)	PLKTLPSQCLPPIkLPEECIYR.QSWTVGKLDLLPPGPAMPFIKDGDGSTMDQE.YGPAYTPQTHTPF
  973- 1039 (112.56/56.17)	PGSAPPSNGGAGI.LPSPSTPRfPTPRTPRTPRTPRGAGGPASAQGSVKYENSDlYSPASTPSTCRPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.08|      19|      64|    1475|    1493|       4
---------------------------------------------------------------------------
 1475- 1493 (33.48/16.75)	SALPPVTASTGNPNTPSAP
 1496- 1514 (27.26/12.10)	STSSTMTATSNSAMSSAAT
 1542- 1559 (31.34/15.15)	SSFPPFS.SMNNTTSASLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     143.25|      39|      39|     685|     723|       5
---------------------------------------------------------------------------
  685-  719 (54.24/32.84)	.....EG.DVEFLF.PDSKKDRQNIERETGKKH..KAEDGTSGV
  720-  756 (38.80/21.14)	TVLShEGeDAMSLFsPSVKQDAQRI.....AAH..ARTASTSLI
  761-  796 (50.21/29.79)	LVVS.YT.DLDNLF..NSDED....ELTPGSKRtvNGADDKSNC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     206.43|      65|     263|      24|      95|       6
---------------------------------------------------------------------------
   24-   95 (114.20/74.72)	PVTEEDPILSSFSRCLKADVLSVWRRDQRPGRRelWI.FWWGDDPNFAD.LIHH......DLSEE.EDGVWEnglsyEC...RT
  290-  366 (92.23/47.51)	PASTRDPAMSSVTLTPPTSPEEVQTVDAQSAQK..WVkFSSVSDGFISDsTSHHggkiprKLANQvVDRVWQ.....ECnmnRT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.34|      37|      67|    1155|    1194|       7
---------------------------------------------------------------------------
 1155- 1194 (55.76/45.79)	AVEHGSAGLKEPE..KLpDEliLLLQDQCTNLFSPFGAAD......QD
 1220- 1264 (56.58/35.01)	ALEHGRQFMDNMSggKV.DE..ALVKTTCLHHWSKRNVVDvsmqcsQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.13|      19|     117|    1276|    1308|      12
---------------------------------------------------------------------------
 1279- 1297 (36.07/39.41)	AIQKKRTVRSWGVQGPLTW
 1815- 1833 (35.06/ 8.36)	ARRKKGSARRLGLQKLWEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.42|      11|    1146|     416|     429|      14
---------------------------------------------------------------------------
  417-  429 (18.42/19.46)	QQGQAPpvGQQQQ
 1566- 1576 (23.00/ 8.81)	QNGQTG..GQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.34|      44|    1197|     170|     223|      15
---------------------------------------------------------------------------
  170-  223 (60.10/62.49)	EHLTLAQqsNSPFQVILsPFGLNGTLTGQSFKLSDsstkKLIGEWkqfYPVTSN
 1384- 1427 (81.24/50.66)	ESCRLGQ..HRPICKLL.PDGIMRVGPTASKKLSE....KLVTEW...FSQTAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.84|      11|    1197|     262|     272|      16
---------------------------------------------------------------------------
  262-  272 (22.54/11.27)	LVPQTDIPPPS
 1460- 1470 (20.29/ 9.29)	LLAQTNLVPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.42|      33|      48|    1657|    1691|      17
---------------------------------------------------------------------------
 1657- 1691 (54.25/36.64)	FLEMVQVLP..PNIKNIISVQivPCQYLLQPVKHEDR
 1706- 1740 (52.17/29.49)	FTQCRRPLPssTNVKTLTGFG..PGLAMETALKSPDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.31|      30|      40|     832|     863|      19
---------------------------------------------------------------------------
  832-  863 (49.83/32.03)	F.SPMNMNNKEYGSMDTTLGGTVLEGnsSSMGA
  873-  903 (52.48/28.18)	FcSPKPAEIKDYSYVYKPENCQALVG..CSMFA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27753 with Med13 domain of Kingdom Metazoa
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