<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27746

Description Mediator of RNA polymerase II transcription subunit 1
SequenceLTEAEKLNKMSTLLERLHAKYNQNRPWTETMKLVRRIEEKRVVMNSGGHQHLVSCLETLQKALKVSSLPAMTDRLESIARQNGLGSHLSANGTECYITSDMFYVEVQLDPTGLLCDVKVAHHGENPVSCPELVQHLREKNFDEFSKHLRGLVNLYKLPGDNKLKTKMYLALQSLELDLSKMAGMYWQATNANPLDKILHGSVGYLTPRSGGLLMNLKYYVSPYDLFEDGTGAPVILHESNVPRSLGMNVSVTVEGTMAMYKLPIAPLIMGSHPVDSKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRAFIQKLQSCTGIPLFDTAPTFVPLYELITQFELSKEADPIPLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLISKIAFQHPGRVPLILNLIRHQVAYNTLIGSCVKRTVLKEDSPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPASSPGYGMTTGSNPMSGTTTPTNTFPGGPITTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSAIGSSPTPPHHTPPPLSSPAGNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEVGPGGSKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPATNEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPNSDSSNHFFPDGVDFNPDLLNSQSQSGFAEEYFDESSQSGDADDFKGYASQALSTLGVQVLGGDGGDNKFKGSNPSDTVDFSIIAAASKALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSXGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLYSSQGGSSSGPSKSSVQSVGKPGSSPITKHGLSSGSGSAKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGAEFQGKREKSDKEKSKVSVSGGSVDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDGLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSMKPESWSKSPISADQSLSMASSAILAAERPARPSPEFLIGEEDDDLMDVALIGN
Length1553
PositionMiddle
OrganismMeleagris gallopavo (Wild turkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Archelosauria> Archosauria> Dinosauria> Saurischia> Theropoda> Coelurosauria> Aves> Neognathae> Galloanserae> Galliformes> Phasianidae> Meleagridinae> Meleagris.
Aromaticity0.05
Grand average of hydropathy-0.621
Instability index54.99
Isoelectric point8.82
Molecular weight164964.69
Publications
PubMed=20838655

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364059
GO - Cellular Component
mediator complex	GO:0016592	IEA:Ensembl
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl
GO - Biological Function
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IEA:Ensembl
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription corepressor activity	GO:0003714	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IEA:Ensembl
GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
angiogenesis	GO:0001525	IEA:Ensembl
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IEA:Ensembl
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
lens development in camera-type eye	GO:0002088	IEA:Ensembl
liver development	GO:0001889	IEA:Ensembl
megakaryocyte development	GO:0035855	IEA:Ensembl
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	IEA:Ensembl
negative regulation of apoptotic process	GO:0043066	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
negative regulation of neuron differentiation	GO:0045665	IEA:Ensembl
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27746
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     637.29|      76|      76|    1042|    1117|       1
---------------------------------------------------------------------------
  608-  687 (56.07/10.21)	...........................GSAIG.....SSPTPPHHTPPP..........................LSSPA.....GNTKNHPmlmnllKENPPQdfSTlyGSsplerQNS.SSGSPrMEVGPGGS..KQK..K.K...KSRM
  978- 1033 (69.76/14.54)	...PKR.....K..KQETD........G.............KS.PSHSS..........................SNRPF.....TPPASTG.........GSK..SP..GS.....SGR.S.......QTPPGV..ATP..PiP...KITI
 1042- 1117 (128.56/33.17)	VGKPSS.....H..GQYTS........SGSVT.....SSSSKSHHSHSS..........................SSSSS.....SSSSTSG......KIKSSK..SE..GS.....SGS.KMSSS.LYSSQGGS..SSG..P.S...KSSV
 1120- 1195 (92.59/21.78)	VGKPGSspitkH..GLSSG........SG...........SAKMKPQGK..........................PSSLM.....NPSMSKP......NISPSH..SR..PS.....GGSdKLASP.MKPVPGTP..PSS..K.A...KSPI
 1197- 1273 (83.73/18.97)	SGSGGS.....H....MSG........TGS.......SSSMKSSSGMGS..........................SGSMSqkpppSSNSSTA.........SSS..SF..SS.....SGS.SMSSS...QNQHGS..SKGksP.SrnkKPSL
 1277- 1361 (70.41/14.75)	IDK.LK.....H..GVVTSgpggddpmDGQMG.....PSSNSSSHTM.S..........................SKHNM.....SGAEFQG......KREKSD..KE..KS.kvsvSGG.SVDSS.KKTSDSKNvgSTG..V.A...K...
 1364- 1441 (74.50/16.05)	...ISK.....HdgGSPSI........KAKVTlqkpgEGGGDGLRPQMA..........................SSKSY.....GSPLISG........STPK..HE..RC.....SPS.HSKSP.AYTPQNID..SES..E.S...GSSI
 1442- 1534 (61.67/11.98)	AEK.SY.....Q..NSPSS........DDGIR.....PLPEYSSEKHKKhkkekkkvkdkdrdrdrdrdkdrdkkKSHSM.....KPESWS.........KSPI..SA..DQ.....SLS.MASSA.ILAAERPA..RPS..P.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     208.83|      37|      37|     753|     789|       2
---------------------------------------------------------------------------
  753-  789 (57.28/27.78)	PS..IQRMVRLSSSDS...IGADVTDI.......LS.........DIAE.EAS..KLPATN
  793-  829 (44.60/19.91)	PP..IGTPVRDSSSS.....GHSQSAL.......FD........pDVFQtNNS..ENPYTD
  830-  871 (43.04/18.94)	PAdlIADAAVSPNSDSsnhFFPDGVDF.......NP.........DLLN.SQS..QSGFAE
  872-  915 (28.50/ 9.93)	EY..FDE.....SSQS...GDAD..DFkgyasqaLStlgvqvlggDGGD.N....KFKGSN
  916-  950 (35.41/14.21)	PSdtVDFSIIAAASKA...LGS.............S.........DIME.HHSggQSPLLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     191.56|      40|      48|     316|     355|       3
---------------------------------------------------------------------------
  278-  310 (41.38/20.39)	....G.TPSFSSI.TSANSVDL.PACFF...L.KFP..RP..IPVSRA.
  316-  355 (72.68/42.04)	QSCTG.IPLFDTAPTFVPLYEL.ITQFE...LSKEA..DP..IPLNHNM
  365-  404 (48.30/25.17)	QHC...YFLNKDAP..LPDGRS.LQGTL...ISKIAfqHPgrVPLILNL
  416-  450 (29.20/11.96)	GSCVKrTVLKEDSP........gILQFEvcpLSDSC..FS..VSFQH..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     280.19|      91|      98|      19|     116|       4
---------------------------------------------------------------------------
   19-  116 (136.33/105.94)	AKYNQNrPwTETMKLVRRIEEKRVVMNSGGHQHLVScLETL..QKALKVSSLPAMTDRLESIARQNGL.GSHLSANGTECYITSDMFYvevqLDPT..GLLCD
  120-  215 (143.86/88.27)	AHHGEN.P.VSCPELVQHLREKNFDEFSKHLRGLVN.LYKLpgDNKLKTKMYLALQSLELDLSKMAGMyWQATNANPLDKILHGSVGY....LTPRsgGLLMN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.57|      30|     182|     514|     565|       6
---------------------------------------------------------------------------
  533-  565 (44.98/55.51)	NLPASSPGYGMTTGSnPmSGTTTPTNTFPgGPI
  719-  748 (59.59/22.89)	NMTADTLDTPHITPA.P.SQCSTPPTTYP.QPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.65|      22|     118|     576|     597|       7
---------------------------------------------------------------------------
  576-  597 (40.80/22.90)	KERHDSVG..HGEDFS.KV.SQNPIL
  691-  716 (27.84/13.26)	KPKHQTEDdfQRELFSmDVdSQNPIF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27746 with Med1 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALGSSDIMEHHSGGQSPLLNTGDLGKEKSQKRVKEGNGSXGKSKEKLPKRKKQETDGKSPSHSSSNRPFTPPASTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSSHGQYTSSGSVTSSSSKSHHSHSSSSSSSSSSSTSGKIKSSKSEGSSGSKMSSSLYSSQGGSSSGPSKSSVQSVGKPGSSPITKHGLSSGSGSAKMKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSGSMSQKPPPSSNSSTASSSSFSSSGSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTSGPGGDDPMDGQMGPSSNSSSHTMSSKHNMSGAEFQGKREKSDKEKSKVSVSGGSVDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDGLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKEKKKVKDKDRDRDRDRDKDRDKKKSHSMKPESWSKSPISADQSLSMASSAILAAERPARPSPEFLIGEEDDD
2) NLPASSPGYGMTTGSNPMSGTTTPTNTFPGGP
3) TTLFNMSISMKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSAIGSSPTPPHHTPPPLSSPAGNTKNHPMLMNLLKENPPQDFSTLYGSSPLERQNSSSGSPRMEVGPGGSKQKKKKSRMPADKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTADTLDTPHITPAPSQCSTPPTTYPQPIPHSQPSIQRMVRLSSSDSIGADVTDILSDIAEEASKLPATNEDCPPIGTPVRDSSSSGHSQSALFDPDVFQTNNSENPYTDPADLIADAAVSPN
931
533
566
1544
564
842










Molecular Recognition Features






MoRF SequenceStartStop




NANANA