Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | TMENFSALFGAQADPPPPPTALGFGPGKPPPPPPPPPGGGPGTAQPPTAATAPPGADKSAAGCGPFYLMRELPGSTELTGSTNLITHYNLEHSYNKFCGKKVKEKLSNFLPDLPGMIDLPGSHDNSSLRSLIEKPPILGGSFNPITGTMLAGFRLHTGPLPEQCRLMHIQPPKKKNKHKHKQSRTQDPVPPETPSDSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPDHPGVGSSQASSSSSLR |
Length | 245 |
Position | Head |
Organism | Ailuropoda melanoleuca (Giant panda) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ailuropoda. |
Aromaticity | 0.04 |
Grand average of hydropathy | -1.024 |
Instability index | 62.49 |
Isoelectric point | 9.83 |
Molecular weight | 26377.81 |
Publications | PubMed=20010809 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP27739 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 75.37| 16| 16| 15| 30| 1 --------------------------------------------------------------------------- 15- 30 (37.08/10.59) PPPPPTALGFGPGKPP 32- 47 (38.29/11.14) PPPPPPGGGPGTAQPP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 79.91| 16| 17| 191| 206| 2 --------------------------------------------------------------------------- 171- 184 (25.73/ 9.99) P..PKKKNKHKHKQSR 191- 206 (27.40/11.02) PETPSDSDHKKKKKKK 210- 225 (26.77/10.63) PERKRKKKEKKKKKNR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 131.62| 40| 46| 69| 114| 3 --------------------------------------------------------------------------- 69- 112 (68.72/45.05) MRELPGSTELTGSTNLITHYN.LEHSYNKFCGkkvkEKLSNF......LPD 116- 162 (62.90/28.97) MIDLPGSHDNSSLRSLIEKPPiLGGSFNPITG....TMLAGFrlhtgpLPE --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DSDHKKKKKKKEEDPERKRKKKEKKKKKNRHSPD 2) GPGKP 3) TMENF | 196 25 1 | 229 29 5 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab