<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27734

Description Mediator of RNA polymerase II transcription subunit 13
SequenceCNFFVFFQAELTGIKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEELKEEEELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVAGAGGHITVGQQGLGSVKDPSNCGMPLTPPTSPEQAVIGESGGTQSAVSHLGSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKRSQMSTPTLEEEPANNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPSRPPAISQPGFSAGPSSSSSLPPPASKHKTTERPEKGDKLQKRPLIPFHHRPSVADEFCMEQDTPGQKLGLAGMDSSLEVSSSRKYDKQMAVPSRNTSKQLNLNPMDSPHSPISPLPPTLSPQPRGQETESLDPPSVPVNPALYGNGLELQQLSTLDDRTVLVGQRLPLMAEVSETALYCGVRPSNPESSDKWWHSYRLPPIDDAEFRPPELQGDRCDAKMEVNSESTALQRLLAQPNKRFKIWQEKQPQMQPLHFLDPLPLAQQPGDSLGEVNDPYTFEDGDIKYIFTANKKCKQGTEKDSLKKNKSEDGFGTKDVTTPGHSTPVPDGKNAMSIFSSATKTDVRQDNAAGRAGSSSLTQVTDLAPSLHDLDNIFDNSDDDELGAVSPALRSSKMPAVGAEDRPLGKDGRAAVPYPPTVADLQRMFPTPPSLEQHPAFSPVMNYKDGISSETVTALGMMESPMVSMVSAQLTEFKMEVEDGLGSPKPEEVKDFSYVHKVPSFQPFVGSSMFAPLKMLPSQCLLPLKIPDACLFRPSWAIPPKIEQLPMPPAAIFNRDGYNNVPSVGSLADPDYLNTPQMNTPVTLNSAAPASNSGAGVLPSPATPRFSVPTPRTPRTPRTPRGGGTASGQGSVKYDSTDQGSPASTPSTTRPLNSVEPATMQPIPEAHSLYVTLILSDSVMNIFKDRNFDSCCICACNMNIKGADVGLYIPDSSNEDQYRCTCGFSAIMNRKLGYNSGLFLEDELDIFGKNSDIGQAAERRLMMCQTTFVPQMEGARKSQEPPISLLLLLQNQHTQPFASLSFLDYISSNSRQTLPCVSWSYDRVQADNNDYWTECFNALEQGRQYVDNPTGGKVDEALVRSATVHSWPHSNVLDISMLSSQDVVRMLLSLQPFLQDAIQKKRTGRTWENIQHVQGPLTWQQFHKMAGRGTYGSEESPEPLPIPTLLVGYDKDFLTISPFSLPFWERLLLDPYGGHRDVAYIVVCPENEALLEGAKTFFRDLSAVYEMCRLGQHKPICKVLRDGIMRVGKTVAQKLTDELVSEWFNQPWSSEENDNHSRLKLYAQVCRHHLAPYLATLQLDSSLLIPPKYQSPPATAQGQATPGNSGPLASNSGSAAPSAGSAFNPTSNSSSGNPAASSSASGSSVPPISSSAPAPVINQISTTSSSGFSASVGGQNPSTGASSADRTQGNIGCGGDTEPGQSSSQPSQDGQESVTERERIGIPTEPDSADSQAYPPAVVIYMVDPFTYTADEDSTSGNFWLLSLMRCYTEMLDNLPEHMRNSFILQIVPCQYMLQTMKDEQVFYIQYLKSMAFSVYCQCRRPLPTQIHIKSLTGFGPAASIEMTLKNPERPSPIQLYSPPFILAPIKDKQTELGETFGEASQKYNVLFVGYCLSHDQRWLLASCTDLHGELLETCIVNIALPNRSRRSKVSARKIGLQKLWEWCIGIVQMTSLPWRVVIGRLGRLGHGELKDWSILLGECSLQTISKRLKDVCRMCGISAADSPSILSACLVAMEPQGSFVVMPDAVTMGSVFGRSTALNMQSSQLNTPQDASCTHILVFPTSSTIQVAPANYPNEDGFSPNNDDMFVDLPFPDDMDNDIGILMTGNLHSSPNSSPVPSPGSPSGIGVGSHFQHSRSQGERLLSREAPEELKQQPLALGYFVSTAKAENLPQWFWSSCPQAQNQCPLFLKASLHHHISVAQTDELLPARNSQRVPHPLDSKTTSDVLRFVLEQYNALSWLTCNPATQDRTSCLPVHFVVLTQLYNAIMNIL
Length2194
PositionMiddle
OrganismAiluropoda melanoleuca (Giant panda)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ailuropoda.
Aromaticity0.07
Grand average of hydropathy-0.381
Instability index58.64
Isoelectric point5.66
Molecular weight241190.31
Publications
PubMed=20010809

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27734
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     221.03|      28|      28|    1017|    1044|       1
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  421-  446 (43.31/13.17)	GPSRPP..AI.SQPGFSAGPSSSS.SLPPP
 1007- 1034 (42.46/12.78)	LNSAAP..ASNSGAGVLPSPATPRFSVPTP
 1035- 1062 (38.61/11.04)	RTPRTP..RTPRGGGTASGQGSVKYDSTDQ
 1526- 1551 (36.41/10.03)	GNSGPL..ASNSGSAA.PS.AGSAFNPTSN
 1552- 1576 (29.07/ 6.69)	SSSGNP..AASSSASGSSVPPISS.SAP..
 1606- 1631 (31.17/ 7.65)	SADRT.qgNIGCGGDTEPGQSS...SQPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.55|      25|      28|    1110|    1134|       2
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 1110- 1134 (51.64/28.79)	NFDSC.CICACN..MNIK.GADVGLYIPD
 1137- 1165 (36.91/18.61)	NEDQYrCTCGFSaiMNRKlGYNSGLFLED
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.93|      26|      28|    2052|    2079|       3
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 2052- 2079 (37.05/33.38)	GsHFQhSRSQGERL...LSREAPEELKQQPL
 2082- 2110 (44.88/29.05)	G.YFV.STAKAENLpqwFWSSCPQAQNQCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.69|      12|      28|     526|     537|       4
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  526-  537 (24.80/11.82)	NPMDSPHSPISP
  552-  563 (22.89/10.21)	ESLDPPSVPVNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.92|      17|      17|     580|     596|       6
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  565-  583 (20.07/ 8.99)	LYGNGLELqqLSTLDDRTV
  584-  600 (26.85/14.74)	LVGQRLPL..MAEVSETAL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.54|      20|      21|     949|     968|       8
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  949-  968 (38.88/21.38)	IPDACLF.RPSWAIPPKIEQL
  970-  990 (32.65/16.67)	MPPAAIFnRDGYNNVPSVGSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.49|      21|      21|    1671|    1691|       9
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 1671- 1691 (38.84/24.83)	YTADE.DSTSGNFWLLSLMRC.Y
 1693- 1715 (30.65/17.87)	EMLDNlPEHMRNSFILQIVPCqY
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.51|      14|      20|    1359|    1372|      11
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 1359- 1372 (27.59/13.51)	SPEPLPI..PTLLVGY
 1380- 1395 (22.92/ 9.86)	SPFSLPFweRLLLDPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.94|      14|      17|     753|     769|      12
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  753-  766 (23.25/17.61)	NAMSIFSSATKTDV
  770-  783 (22.70/ 7.73)	NAAGRAGSSSLTQV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.41|      14|      17|     209|     224|      13
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  209-  222 (24.00/19.97)	YKMSDPATRKLIEE
  227-  240 (23.41/ 9.66)	YPMVLKKKEELKEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.27|      32|    1265|     140|     173|      14
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  140-  173 (52.23/52.37)	PVNKSeHLSCAFTFFlHGESNVCTSVEIAQHQPI
 1408- 1439 (59.04/47.41)	PENEA.LLEGAKTFF.RDLSAVYEMCRLGQHKPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.07|      18|      28|    2003|    2025|      15
---------------------------------------------------------------------------
 2003- 2025 (24.82/23.18)	SPNNDdmfvDLPFPDDmDNDIGI
 2034- 2051 (34.25/15.70)	SPNSS....PVPSPGS.PSGIGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.28|      25|      27|      44|      68|      18
---------------------------------------------------------------------------
    3-   31 (38.01/23.67)	FFVFFQAELTGI...........kWRRynfGGHGDCGPII
   44-   68 (48.29/32.49)	FIRCLQANLLCV............WRR...DVKPDCKELW
   70-  105 (32.99/19.36)	FWWGDEPNLVGVihhelqvveeglWEN...GLSYECRTL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.43|      12|      27|     347|     358|      19
---------------------------------------------------------------------------
  347-  358 (22.36/11.16)	KRSGKIPPKLHN
  376-  387 (21.06/10.07)	KRSQMSTPTLEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.63|      13|      17|    1577|    1589|      20
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 1577- 1589 (21.80/11.61)	APVINQISTTSSS
 1593- 1605 (22.84/12.55)	ASVGGQNPSTGAS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.71|      24|     111|     673|     698|      21
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  673-  698 (37.92/26.06)	MQP.LHFLDPLpLAQQPGDSLGEVNdP
  786-  810 (38.79/17.78)	LAPsLHDLDNI.FDNSDDDELGAVS.P
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.87|      23|     628|     836|     859|      22
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  836-  859 (41.82/24.97)	PYPPTVaDLQRMFPTPPSLEQHPA
 1495- 1517 (42.05/21.01)	PYLATL.QLDSSLLIPPKYQSPPA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27734 with Med13 domain of Kingdom Metazoa
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