<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27729

Description Mediator of RNA polymerase II transcription subunit 15
SequenceLLCYSEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPTAGAAGIGMPSRGPGQSLGGMGGLGTMGQPMPLSGQPPPGTSGMAPHGMAVVSAAAPQTQLQLQQVALQQQQQQFQQQQVALQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQQQLQQQQQQQHLIKLHHQNQQQIQQQQQLQRMAQLQLQQQQQQQQQQQALQAQPPLQQPPMQQPQPPPSQALPQQLQPMHHPQHHQPPPQPQQPPVAPNQPSQLPPQSQTQPLVSQAPALPGQMLYAQPQLKLIAFSLLPQVRTPMVVQQPQVQPQVQQVQPQVQQQPAVPTAQASQIVGSASPRLGVQGWQPVYGSALETEERQHDGARRQRTAQACATAPRSAGCQDWPSVPRRKRWGQGARAHSPPRQSRGEAPHHAHHAVTLMGARPTGQRGRKRARQEAASGSAGQCVAASRGEVSQNSLTMLSSPSPGQQVQTPQSMPPPPQPSPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRFEDDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
Length857
PositionTail
OrganismAiluropoda melanoleuca (Giant panda)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ailuropoda.
Aromaticity0.03
Grand average of hydropathy-0.746
Instability index86.60
Isoelectric point9.74
Molecular weight93982.44
Publications
PubMed=20010809

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27729
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.61|      18|      19|     207|     225|       3
---------------------------------------------------------------------------
  214-  233 (25.99/ 6.51)	QQLQRMAQLQLQqQQQQQqQ
  508-  525 (32.61/ 6.41)	QSMPPPPQPSPP.PPQPS.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     199.30|      38|      38|     391|     428|       8
---------------------------------------------------------------------------
   99-  132 (47.35/15.91)	GTMGQP.MP...LSGQ..PPpgTSGMAPHG......MAVVSAAAPQ..
  374-  412 (60.23/22.34)	GVQGWQPVYGSALETE.eRQ..HDGARRQR......TAQACATAPRSA
  413-  447 (56.41/20.43)	GCQDWPSVPRRKRWGQgaRA..HSPPRQSR...........GEAPHHA
  455-  486 (35.31/ 9.90)	GAR..PT.......GQ..R.....GRKRARqeaasgSAGQCVAASRGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.21|      26|      28|     632|     658|      10
---------------------------------------------------------------------------
  602-  618 (20.15/ 6.85)	.............LDKLKQLSKYI.EPLRRM
  619-  649 (36.03/15.68)	INKIDKNEdrkkdLSKMKSLLDILTDPSKRC
  651-  678 (40.04/24.13)	LKTLQKCE...iaLEKLKNDMAVPTPPPPPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.36|      12|      72|     495|     507|      11
---------------------------------------------------------------------------
  495-  507 (19.58/ 8.57)	LSSPSPGqQVQTP
  570-  581 (23.78/ 7.02)	FSVPSPG.PLNTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.38|      14|      18|      67|      80|      13
---------------------------------------------------------------------------
   67-   80 (24.02/12.60)	LQSLTGGPTAGAAG
   83-   96 (27.35/15.52)	MPSRGPGQSLGGMG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27729 with Med15 domain of Kingdom Metazoa
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