<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27724

Description Mediator complex subunit 12 like
SequencePFLEQDELTAVNVKQGFNNQPAFTGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQATDPNLDAEWTQISTRYLREQLAKISDFYHVASSTGEGPIPVPPDVEQARKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLALLLSDSPSLLAAHSPHMMIGPNNSSIGAPSPGPPGPVMSPVQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNDNKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEVEAERCGESEVLDEKESISSASLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPAGENVDEHYPKDHDMKMEEQTIMAHMGIDSGTNIFDEVDKNDFKTDFGSEFPCHLKGYISFLFPDLSKEQKKPKWEEKIHDTLGVIHPPTKHVDYAAHFPIFIFQDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGEKKKKLATCKSYNPTFLGFLVGDEGPKTRKNKQEAFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACVLPQATGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGNNNNDDFTMRGLRRDGNADDIWTASQNSKSCGKSISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTEGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPEMNNLLDNIAKATIEVFQQSADLSIASGKVCSTIWYLARGKVVQSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTAIDEEKKTKGRKRKTKSSSRVDYYYLPMRTKTYLFLADSLMLHHPQSTLWGYNLMGQPQQPGFFLQNQSLAPGGSRLDPTGSFVPTNTKQALSNMLQRRSGAMMQPPPLHAITSQQQLIQMKVLQQQQRLLRQAQARPFQQCLLSASKIHQYDSQSTYFLTMPQGYTMYGTQMPLQQTPQPQAGGVVLSPSYSSRTYPAAHSNPALMERLRQMQQQPSGYVQQQASPYLQPLTGSQSRLNHQSLQQSPLVGGGIDAVLTSTHPSLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPPQPQQPPQPQSQTLGLQAMQPQQPLVTEQHELLKKEQQRQVSHPRLQQEHGTAPVPEKSKIQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHP
Length2156
PositionKinase
OrganismAiluropoda melanoleuca (Giant panda)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ailuropoda.
Aromaticity0.07
Grand average of hydropathy-0.402
Instability index54.38
Isoelectric point7.77
Molecular weight242254.03
Publications
PubMed=20010809

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27724
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     618.49|     113|     117|    1829|    1941|       1
---------------------------------------------------------------------------
 1637- 1735 (120.26/69.28)	.........EPMGSLIDTkGNKIAGFD.SIDKKQG..LQ.......VSTKQKVS..PWDLFEGQKNPAPLSWAW.FGTVRV.D......RKVIKYEEQHHLLLyhthPM................PKPRSYYL........EPLPLPPEEEE.
 1737- 1821 (91.99/50.82)	.........EPT.....................SPVSQEPE.RKSAELSDQGKT..AIDEEKKTKGRKRKTK..........SS.....SRVDYY......YL....PMrtktylfladslmlhhPQS.TLWG........YNL.MGQPQQPG
 1829- 1941 (203.28/123.50)	LAPG.GSRLDPTGSFVPT.NTKQALSN.MLQRRSGAMMQPP.PLHAITSQQQLI..QMKVLQQQQRLLRQAQARPFQQCLL.SA.....SKIHQYDSQSTYFL....TM................PQGYTMYG........TQMPLQQTPQPQ
 1947- 2031 (98.84/55.29)	LSPSySSRTYPA...........AHSNpALMERLRQM........................QQQPSGYVQQQASPYLQPLTgSQ.....SRL...NHQS.........L................QQSPLVGGgidavltsTHPSLPSVPLPQ
 2032- 2063 (50.29/23.59)	.........DPMRPRQPQ.VRQQ..QR.LLQ.....MQQPPqP.......................................................................................................QQPPQPQ
 2069- 2128 (53.84/25.90)	...........................................LQAMQPQQPLVteQHELLKKEQQ..RQVSHPRLQQEHG.TApvpekSKI.QFPRQG..............................................LQQTQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.96|      26|     478|     195|     225|       2
---------------------------------------------------------------------------
  195-  225 (37.04/51.06)	PDV..EQARKQWEynEKLafHMfQEGMLE...KH.EY
  676-  707 (36.92/26.75)	PDLskEQKKPKWE..EKI..HD.TLGVIHpptKHvDY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     343.01|     121|     154|    1300|    1453|       3
---------------------------------------------------------------------------
 1300- 1449 (172.63/178.55)	QAQKLLQLI..CYpHGIKECTEG..DNLQRQhIKRILQNleqWtlRQSWLELQLMIKQCLKDP.EMN.NL....LDNIAKATievfQQSADlsiasgkvcstiWYLARGKVVQSSS..............ERRGVWLVAPLIARLPTSVQGrvlkaaGEELEKGQH..LGSSSKKE
 1462- 1608 (170.38/105.27)	SQQPFLSLVltCL.KGQDEQREGllTSLQNQ.VNQILSN...W..REERYQDDIKARQMMHEAlQLRlNLvggmFDTVQRST....QWTTD............WALLLLQIITSGTvdmhtnnelfttvlDMLGVLINGTLASDLSNASPG......GSEENKRAYmnLVKKLKKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     346.58|     112|     189|     827|     941|       4
---------------------------------------------------------------------------
  827-  941 (178.44/128.82)	ISNNVLE..............................QITSFASGTSYHLPLAHHIQLIFDlMEPALNINGLIDFAIQLLNELSVVEAELL..LK....SSSLAGSYTTGLCVCIVAVLrRYHSCL..ILNPDQTAQVFeGLCGVVKHVVNPS
  983- 1132 (168.13/108.96)	IYNNVMPansnlrwdpdfmmdfienpsarsinysmlgKILSDNAANRYSFVCNTLMNVCMG.HQDAGRINDIANFSSELTACCTVLSSEWLgvLKalccSSNHVWGFNDVLCTVDVSDL.SFHDSLatFIAILIARQCF.SLEDVVQHVALPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27724 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) SYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTAIDEEKKTKGRKRK
2) YGTQMPLQQTPQPQAGGVVLSPSYSSRTYPAAHSNPALMERLRQMQQQPSGYVQQQASPYLQPLTGSQSRLNHQSLQQSPLVGGGIDAVLTSTHPSLPSVPLPQDPMRPRQPQVRQQQRLLQMQQPPQPQQPPQPQSQTLGLQAMQPQQPLVTEQHELLKKEQQRQVSHPRLQQEHGTAPVPEKSKIQFPRQGLQQTQQQQQTAALVRQLQKQLSSNQPQQGVTPYGHP
1721
1928
1773
2156










Molecular Recognition Features






MoRF SequenceStartStop




1) KIQFPR
2113
2118