<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27719
| Description |
Mediator of RNA polymerase II transcription subunit 7 |
| Sequence | MGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDADSNNCTGQNEQQRENSGSLEGVYVAEVGQNADLPCVYSPTTSEALVPVCWGRGSCPVFECHSMVLSTDGRSLKYQTSNRYQLKRNIHKGDVSLTIENVTLADGGTYCCRIQFPGIMNDKKLNLELVIKPAKVTSAPTPRRDSTAAFPWILTTKGHGAAETQTLEALHDKQQTQIPTLANELQDAGATTRIGVYIGAGVSAGLALLLIIGALILTWYSYSKEKLQNSSLVSLAKPPPSGLANTGAEGMRSQENIYIIEENIYEMEDPYEYYCYVNNGQQ |
| Length | 469 |
| Position | Middle |
| Organism | Ailuropoda melanoleuca (Giant panda) |
| Kingdom | Metazoa |
| Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia>
Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ailuropoda.
|
| Aromaticity | 0.06 |
| Grand average of hydropathy | -0.437 |
| Instability index | 45.70 |
| Isoelectric point | 5.56 |
| Molecular weight | 52742.59 |
| Publications | PubMed=20010809
|
Function
| Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
|
| GO - Cellular Component | cell surface GO:0009986 IEA:Ensembl
early endosome GO:0005769 IEA:Ensembl
immunological synapse GO:0001772 IEA:Ensembl
integral component of membrane GO:0016021 IEA:UniProtKB-KW
mediator complex GO:0016592 IEA:InterPro
|
| GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
| GO - Biological Process | cellular response to lipopolysaccharide GO:0071222 IEA:Ensembl
defense response to Gram-positive bacterium GO:0050830 IEA:Ensembl
macrophage activation involved in immune response GO:0002281 IEA:Ensembl
maternal process involved in female pregnancy GO:0060135 IEA:Ensembl
natural killer cell tolerance induction GO:0002519 IEA:Ensembl
negative regulation of defense response to bacterium GO:1900425 IEA:Ensembl
negative regulation of granulocyte colony-stimulating factor production GO:0071656 IEA:Ensembl
negative regulation of immunological synapse formation GO:2000521 IEA:Ensembl
negative regulation of interferon-alpha production GO:0032687 IEA:Ensembl
negative regulation of interferon-gamma production GO:0032689 IEA:Ensembl
negative regulation of interleukin-2 production GO:0032703 IEA:Ensembl
negative regulation of interleukin-3 production GO:0032712 IEA:Ensembl
negative regulation of interleukin-6 production GO:0032715 IEA:Ensembl
negative regulation of myeloid dendritic cell activation GO:0030886 IEA:Ensembl
negative regulation of natural killer cell activation GO:0032815 IEA:Ensembl
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target GO:0002859 IEA:Ensembl
negative regulation of NF-kappaB transcription factor activity GO:0032088 IEA:Ensembl
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell GO:2001189 IEA:Ensembl
negative regulation of T cell proliferation GO:0042130 IEA:Ensembl
negative regulation of T-helper 1 type immune response GO:0002826 IEA:Ensembl
negative regulation of tumor necrosis factor production GO:0032720 IEA:Ensembl
positive regulation of chemokine production GO:0032722 IEA:Ensembl
positive regulation of defense response to bacterium GO:1900426 IEA:Ensembl
positive regulation of ERK1 and ERK2 cascade GO:0070374 IEA:Ensembl
positive regulation of innate immune response GO:0045089 IEA:Ensembl
positive regulation of interferon-gamma production GO:0032729 IEA:Ensembl
positive regulation of interleukin-1 production GO:0032732 IEA:Ensembl
positive regulation of interleukin-4 production GO:0032753 IEA:Ensembl
positive regulation of macrophage activation GO:0043032 IEA:Ensembl
positive regulation of NIK/NF-kappaB signaling GO:1901224 IEA:Ensembl
positive regulation of T cell proliferation GO:0042102 IEA:Ensembl
positive regulation of tumor necrosis factor production GO:0032760 IEA:Ensembl
regulation of tolerance induction dependent upon immune response GO:0002652 IEA:Ensembl
regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
toll-like receptor 3 signaling pathway GO:0034138 IEA:Ensembl
toll-like receptor 7 signaling pathway GO:0034154 IEA:Ensembl
toll-like receptor 9 signaling pathway GO:0034162 IEA:Ensembl
|
Interaction
Repeat regions
| Repeats |
>MDP27719
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 50.91| 15| 389| 21| 36| 1
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21- 36 (26.56/19.16) YTDENIQE....GLApKPPP
409- 427 (24.35/12.10) YSKEKLQNsslvSLA.KPPP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 167.94| 54| 164| 169| 224| 2
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169- 224 (86.43/68.19) ASLPDDLPHSEAGMrVKTEPMDA..DSNNC...TGQNEQQRENSGSLEGVYVAeVGQNADL
335- 393 (81.51/55.06) AAFPWILTTKGHGA.AETQTLEAlhDKQQTqipTLANELQDAGATTRIGVYIG.AGVSAGL
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|
