<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27719

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMGEPQQVSALPPPPMQYIKEYTDENIQEGLAPKPPPPIKDSYMMFGNQFQCDDLIIRPLESQGIERLHPMQFDHKKELRKLNMSILINFLDLLDILIRSPGSIKREEKLEDLKLLFVHVHHLINEYRPHQARETLRVMMEVQKRQRLETAERFQKHLERVIEMIQNCLASLPDDLPHSEAGMRVKTEPMDADSNNCTGQNEQQRENSGSLEGVYVAEVGQNADLPCVYSPTTSEALVPVCWGRGSCPVFECHSMVLSTDGRSLKYQTSNRYQLKRNIHKGDVSLTIENVTLADGGTYCCRIQFPGIMNDKKLNLELVIKPAKVTSAPTPRRDSTAAFPWILTTKGHGAAETQTLEALHDKQQTQIPTLANELQDAGATTRIGVYIGAGVSAGLALLLIIGALILTWYSYSKEKLQNSSLVSLAKPPPSGLANTGAEGMRSQENIYIIEENIYEMEDPYEYYCYVNNGQQ
Length469
PositionMiddle
OrganismAiluropoda melanoleuca (Giant panda)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ailuropoda.
Aromaticity0.06
Grand average of hydropathy-0.437
Instability index45.70
Isoelectric point5.56
Molecular weight52742.59
Publications
PubMed=20010809

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
ECO:0000256	RuleBase:RU364060
GO - Cellular Component
cell surface	GO:0009986	IEA:Ensembl
early endosome	GO:0005769	IEA:Ensembl
immunological synapse	GO:0001772	IEA:Ensembl
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
cellular response to lipopolysaccharide	GO:0071222	IEA:Ensembl
defense response to Gram-positive bacterium	GO:0050830	IEA:Ensembl
macrophage activation involved in immune response	GO:0002281	IEA:Ensembl
maternal process involved in female pregnancy	GO:0060135	IEA:Ensembl
natural killer cell tolerance induction	GO:0002519	IEA:Ensembl
negative regulation of defense response to bacterium	GO:1900425	IEA:Ensembl
negative regulation of granulocyte colony-stimulating factor production	GO:0071656	IEA:Ensembl
negative regulation of immunological synapse formation	GO:2000521	IEA:Ensembl
negative regulation of interferon-alpha production	GO:0032687	IEA:Ensembl
negative regulation of interferon-gamma production	GO:0032689	IEA:Ensembl
negative regulation of interleukin-2 production	GO:0032703	IEA:Ensembl
negative regulation of interleukin-3 production	GO:0032712	IEA:Ensembl
negative regulation of interleukin-6 production	GO:0032715	IEA:Ensembl
negative regulation of myeloid dendritic cell activation	GO:0030886	IEA:Ensembl
negative regulation of natural killer cell activation	GO:0032815	IEA:Ensembl
negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	GO:0002859	IEA:Ensembl
negative regulation of NF-kappaB transcription factor activity	GO:0032088	IEA:Ensembl
negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	GO:2001189	IEA:Ensembl
negative regulation of T cell proliferation	GO:0042130	IEA:Ensembl
negative regulation of T-helper 1 type immune response	GO:0002826	IEA:Ensembl
negative regulation of tumor necrosis factor production	GO:0032720	IEA:Ensembl
positive regulation of chemokine production	GO:0032722	IEA:Ensembl
positive regulation of defense response to bacterium	GO:1900426	IEA:Ensembl
positive regulation of ERK1 and ERK2 cascade	GO:0070374	IEA:Ensembl
positive regulation of innate immune response	GO:0045089	IEA:Ensembl
positive regulation of interferon-gamma production	GO:0032729	IEA:Ensembl
positive regulation of interleukin-1 production	GO:0032732	IEA:Ensembl
positive regulation of interleukin-4 production	GO:0032753	IEA:Ensembl
positive regulation of macrophage activation	GO:0043032	IEA:Ensembl
positive regulation of NIK/NF-kappaB signaling	GO:1901224	IEA:Ensembl
positive regulation of T cell proliferation	GO:0042102	IEA:Ensembl
positive regulation of tumor necrosis factor production	GO:0032760	IEA:Ensembl
regulation of tolerance induction dependent upon immune response	GO:0002652	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
toll-like receptor 3 signaling pathway	GO:0034138	IEA:Ensembl
toll-like receptor 7 signaling pathway	GO:0034154	IEA:Ensembl
toll-like receptor 9 signaling pathway	GO:0034162	IEA:Ensembl

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27719
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.91|      15|     389|      21|      36|       1
---------------------------------------------------------------------------
   21-   36 (26.56/19.16)	YTDENIQE....GLApKPPP
  409-  427 (24.35/12.10)	YSKEKLQNsslvSLA.KPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.94|      54|     164|     169|     224|       2
---------------------------------------------------------------------------
  169-  224 (86.43/68.19)	ASLPDDLPHSEAGMrVKTEPMDA..DSNNC...TGQNEQQRENSGSLEGVYVAeVGQNADL
  335-  393 (81.51/55.06)	AAFPWILTTKGHGA.AETQTLEAlhDKQQTqipTLANELQDAGATTRIGVYIG.AGVSAGL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27719 with Med7 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) PMQYIKEYTDEN
14
25