<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27717

Description Cyclin dependent kinase 19
SequenceLGMDTCRDVKSLLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQGAGAGLQHSQDSGLNPVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLSYSSSSQQSAQYHSSHQGHRY
Length415
PositionKinase
OrganismAiluropoda melanoleuca (Giant panda)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Carnivora> Caniformia> Ursidae> Ailuropoda.
Aromaticity0.09
Grand average of hydropathy-0.654
Instability index56.06
Isoelectric point8.79
Molecular weight47443.35
Publications
PubMed=20010809

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27717
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.84|      39|      41|     270|     310|       1
---------------------------------------------------------------------------
  270-  310 (66.02/39.29)	EQALQDPYFQEDPLPTLDVFAGCQipYPKREFLNEDEPEEK
  314-  352 (71.82/37.30)	NQQQQQNQHQQPTAPPQGAGAGLQ..HSQDSGLNPVPPNKK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     119.22|      36|      40|     130|     169|       2
---------------------------------------------------------------------------
   94-  120 (31.61/17.39)	.........DLKPANILVMGEGPE.....RGRVKIADMgFA
  123-  162 (59.27/47.74)	FNSPLKPLADLDPVVVTFWYRAPELllgaRHYTKAIDI.WA
  163-  184 (28.35/13.70)	IGCIFAELLTSEPI...FHCRQEDI................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.63|      14|      15|     376|     389|       4
---------------------------------------------------------------------------
  376-  389 (25.79/15.91)	SRLNYQSSVQGSSQ
  392-  405 (24.84/15.09)	STLSYSSSSQQSAQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27717 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PKREFLNEDEPEEKGDKNQQQQQNQHQQPTAPPQGAGAGLQHSQDSGLNPVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLSYSSSSQQSAQYHSSHQGHRY
297
415










Molecular Recognition Features






MoRF SequenceStartStop




1) AQYHSSHQ
2) KKPRLG
3) LNYQS
4) STLSYSSSS
404
351
378
392
411
356
382
400