<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27711

Description Mediator of RNA polymerase II transcription subunit 1
SequenceLLISISLTESEKLNKMSSLLERLHVKFNPNTRPWTETMKLVRQVMEKRVVMNSGGHQNLVSCLETLQKALKVTSLPAMTDRLESIARQNGLGSHLSANGTECYITSDMFYVEVHLDPTGQLCDVKVAHHGENPVSCPELVQHLRERNFDEFSKHLKGLVNLYKLPGDSKLKTKMYLALQSLELDLTKMAVMYWQATNASPLDKILHGSVGYLTPRSGGHLINLKYYVSPYDLIEDGTGVPVILNEGGVPRNLGMNVCVTIEGTLTMNKLPIAPLIMGSHPVDNKGTPSFSSITSANSVDLPACFFLKFPRPIPVSRGFIQKLQNCTGIPLFDTPPTYVPLYELITQFELSKEQDAGSLNHNMRFYAALPGQQHCYFLNKDAPLPDGRSLQGTLLSKIAFHHPSRVPLILNMIRHQVAYNTLIGSCVKRTVLKEDTPGILQFEVCPLSDSCFSVSFQHPVNDSLVCVVMDVQDSTHVNCKLYKGLSDALICTDDFIAKVVQRCMSIPVTMRAIRRKAETIQADTPALSLIAETVEDMVKKNLPPASSPGYGMTTGNNPMSGTTTPTSTFPGGPISTLFTMSMGIKERHDSVGHGEDFSKVSQNPILTSLLQITGNVGSTIGSSPTPPHHTPPPVSSPASNTKNHPMLMNLLKDNPAQDFSTLYGSSPLERQNSSSGSPRMEMGPGTNKQKKKKSRVLVEKPKHQTEDDFQRELFSMDVDSQNPIFDVNMTTDTLDTPHITPAPSQCSTPPTTYPQSISHAQPSIQRMVRLSSSDSIGPDVTDILSDIAEEASKLPSTSEDCHPIGTPVRDSSSSGHSQSALFDPDVFQSNNSDNPYTDPADLIADATVSPNSDSSNQFFPDGVDFNPDLLNSQSQSGFGEEYFDDSSQSGDADDFKGFAPQTISTLGVQVLGGDGGESKFKASSQTDTVDFSIITAASKALGTSDVMEHHSGSQSPLLSAGDLGKEKSQKRVKEGNGSGSSLTGPGMDGKGGKRSRTPSSDGKSKEKVQKRRKVEPEGKSPSHSSSTRPFTPPSSTGGSKSPGSSGRSQTPPGVATPPIPKITIQIPKGTVTVGKPSHGQYTSSGSVSSLSSKSHHSHSSSSSSSSSSSSSSSSSSSSASGKIKSSKSDGSSGSKMSSSLYSGQGGSGSGQSKSSTQSVGKPGSSPITKHGLSSGSGGTKIKPQGKPSSLMNPSMSKPNISPSHSRPSGGSDKLASPMKPVPGTPPSSKAKSPISSGSGGSHMSGTGSSSSMKSSSGMGSSSSMSQKAPPSNSSAGSSSSFSSGSSSMSSSQNQHGSSKGKSPSRNKKPSLTAVIDKLKHGVVTGGPGGEDSMDGQMIQSSSSSSHSMSSKHNLSGSELQGKRERSDKEKSKVSVSGGSSDSSKKTSDSKNVGSTGVAKIIISKHDGGSPSIKAKVTLQKPGEGGGDSLRPQMASSKSYGSPLISGSTPKHERCSPSHSKSPAYTPQNIDSESESGSSIAEKSYQNSPSSDDGIRPLPEYSSEKHKKHKKDKKKLKDKDRDRDRDKERDKKKTHSIKPESWSKSPISSEQSLSMTSSAILTSERSSRPSPDFSIGEEDDDLMDIALIRN
Length1588
PositionMiddle
OrganismAnolis carolinensis (Green anole) (American chameleon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Lepidosauria> Squamata> Bifurcata> Unidentata> Episquamata> Toxicofera> Iguania> Dactyloidae> Anolis.
Aromaticity0.04
Grand average of hydropathy-0.619
Instability index57.10
Isoelectric point8.91
Molecular weight168608.37
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleolus	GO:0005730	IEA:Ensembl
nucleoplasm	GO:0005654	IEA:Ensembl

GO - Biological Function
DNA binding	GO:0003677	IEA:Ensembl
estrogen receptor binding	GO:0030331	IEA:Ensembl
LBD domain binding	GO:0050693	IEA:Ensembl
nuclear receptor coactivator activity	GO:0030374	IEA:Ensembl
peroxisome proliferator activated receptor binding	GO:0042975	IEA:Ensembl
promoter-specific chromatin binding	GO:1990841	IEA:Ensembl
protein-containing complex binding	GO:0044877	IEA:Ensembl
retinoic acid receptor binding	GO:0042974	IBA:GO_Central
thyroid hormone receptor binding	GO:0046966	IBA:GO_Central
transcription coregulator activity	GO:0003712	IBA:GO_Central
transcription corepressor activity	GO:0003714	IEA:Ensembl
vitamin D receptor binding	GO:0042809	IBA:GO_Central

GO - Biological Process
androgen biosynthetic process	GO:0006702	IEA:Ensembl
angiogenesis	GO:0001525	IEA:Ensembl
animal organ regeneration	GO:0031100	IEA:Ensembl
brain development	GO:0007420	IEA:Ensembl
cell morphogenesis	GO:0000902	IEA:Ensembl
cellular response to epidermal growth factor stimulus	GO:0071364	IEA:Ensembl
cellular response to hepatocyte growth factor stimulus	GO:0035729	IEA:Ensembl
cellular response to thyroid hormone stimulus	GO:0097067	IBA:GO_Central
embryonic heart tube development	GO:0035050	IEA:Ensembl
embryonic hemopoiesis	GO:0035162	IEA:Ensembl
embryonic hindlimb morphogenesis	GO:0035116	IEA:Ensembl
enucleate erythrocyte development	GO:0048822	IEA:Ensembl
fat cell differentiation	GO:0045444	IEA:Ensembl
intracellular steroid hormone receptor signaling pathway	GO:0030518	IEA:Ensembl
keratinocyte differentiation	GO:0030216	IEA:Ensembl
lens development in camera-type eye	GO:0002088	IEA:Ensembl
liver development	GO:0001889	IEA:Ensembl
megakaryocyte development	GO:0035855	IEA:Ensembl
monocyte differentiation	GO:0030224	IEA:Ensembl
mRNA transcription by RNA polymerase II	GO:0042789	IEA:Ensembl
negative regulation of apoptotic process	GO:0043066	IEA:Ensembl
negative regulation of keratinocyte proliferation	GO:0010839	IEA:Ensembl
negative regulation of neuron differentiation	GO:0045665	IEA:Ensembl
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:Ensembl
peroxisome proliferator activated receptor signaling pathway	GO:0035357	IEA:Ensembl
positive regulation of erythrocyte differentiation	GO:0045648	IEA:Ensembl
positive regulation of G0 to G1 transition	GO:0070318	IEA:Ensembl
positive regulation of gene expression	GO:0010628	IEA:Ensembl
positive regulation of hepatocyte proliferation	GO:2000347	IEA:Ensembl
positive regulation of interferon-gamma-mediated signaling pathway	GO:0060335	IEA:Ensembl
positive regulation of intracellular estrogen receptor signaling pathway	GO:0033148	IEA:Ensembl
positive regulation of keratinocyte differentiation	GO:0045618	IEA:Ensembl
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
protein import into nucleus	GO:0006606	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
regulation of vitamin D receptor signaling pathway	GO:0070562	IEA:Ensembl
retinal pigment epithelium development	GO:0003406	IEA:Ensembl
thyroid hormone generation	GO:0006590	IEA:Ensembl
thyroid hormone mediated signaling pathway	GO:0002154	IEA:Ensembl
ventricular trabecula myocardium morphogenesis	GO:0003222	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27711
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            10|     965.73|     108|     109|    1068|    1175|       1
---------------------------------------------------------------------------
  588-  703 (61.95/ 9.75)	...............................DS...VG...........H.GED.FS.KVSqnpilTSLLqiTG..NVGSTIGSS..P....TP..PHHTPPPvsspasntknhpmlmnllkdnpaqdfstlyG..SSP..LERQNSS..SGS............PRMEMGPGTNKQKKKKSRV..LVEKPKHQ
  713-  816 (86.90/16.66)	FS.........MDVDS...QNPIFDVNMTTDTL...DTPHITP.AP..SQ.CSTpPT.TYP.....QSIS..HA..QPSIQRMVR..L....SS..SDSIG.P..............................D..VTD..ILSDIAE..EASklpstsedchpiGT.....PVRD...........SSSSGHS
  817-  940 (89.15/17.28)	QSalfdpdvfqSNNSD...NPYTDPADLIADAT...VSPNSDS.SN..QF.FPD.GV.DFN.....PDLL..NS..QSQSGFGEEyfD....DS..SQSGDAD...........................dfkG..FAPqtISTLGVQvlGGD............GGESKFKASSQTDTVDFSIITAASKAL..
  941- 1021 (87.47/16.82)	.G.........TSDVM...EHHSGSQSPLLSAG...DLGKEKS.QKrvKE.GN..GS...G.....SSL...TG..PGMDGKGGK..R....SR..T.....P..............................S..SDG..KSKEKVQ..KRR............KV...........EPEG.......KS.PS
 1022- 1096 (107.06/22.25)	HS.........SSTRP...FTPPSST...........GG.....SK..SP.GSS............................GRS............QT..PP..............................GvaTPP..IPKITIQ..IPK............GTVTVGKPSHGQYTSSGSVSSLSSKSHHS
 1097- 1189 (144.82/32.71)	HS.........SSSSS...SSSSSSSSSSSSSS...ASGKIKS.SK..SD.GSS.GS.KMS.....SSLY..SG..QGGSGSGQS..K....SS..TQSVGKP..............................G..SSP..ITKHGLS..SGS............GGTKI.KP.QGKP......SSL.......
 1190- 1270 (102.78/21.06)	...........MNPSM...SKP.................NISP.SH..SR.PSG.GSdKLA.....SPMK..PV..PGTPPSSKA..K....SP..ISS.GSG..............................G..S.......H..M..SGT............GSSSSMKSSSGM....GSSSSMSQKAPPS
 1271- 1373 (94.68/18.81)	NS.........SAGSS...SSFSSGSSSMSSSQnqhGSSKGKSpSR..NK.KPS.LT.AVI.....DKLK..HGvvTGGPGGEDS..M....DGqmIQSSSSS..............................S..HSM..SSKHNLS...GS.........elqG..........KRERSD.....KEKSKVS
 1374- 1485 (121.27/26.18)	VS.........GGSSD...SSKKTSDSKNVGST...GVAKIII.SK..HD.GGS.PSiKAK.....VTL....Q..KPGEGGGDS..LrpqmAS..SKSYGSP...........................lisG..STP....KHERC..SPS............HSKSPAYTPQNIDSESESGSSIAEKSYQN
 1486- 1575 (69.66/11.88)	SP.........SSDDGirpLPEYSSEKHKKHKK...DKKKLKD.KD..RDrDRD.KE.RDK.....KKTH..SI..KPESWSKSP..I....SS..EQSLSMT..............................S..SAI..LTSERSS..RPS............PDFSIGE......................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     486.95|     153|     165|     114|     274|       2
---------------------------------------------------------------------------
   53-  109 (35.04/11.12)	.....................................................................................................................S.GGHQ.NL...VSCLETLQKAlkvTSLPAMTD..RlESIARQNGLGSHL..SA..NGTECYITSDM..F
  114-  274 (243.15/157.75)	H.LDPTG..QLCDVKVAHHGENPvSCpELVQHLR....ERNFDEFSKHLKGlVNLYKLPgdsKLKTKMYLALQSLELDLTKMA.....VMYWQAtnASPLDK...ILHGSVGYLTPRS.GGHLINLKYYVSPYDLIEDG...TGVPVILN..E.GGVPRNLGMNVCV..TI..EGTLTMNKLPIAPL
  279-  446 (208.75/115.03)	HpVDNKGtpSFSSITSANSVDLP.AC.FFLKFPRpipvSRGFIQKLQNCTG.IPLFDTP...PTYVPLYELITQFELSKEQDAgslnhNMRFYA..ALPGQQhcyFLNKDAPLPDGRSlQGTLLSKIAFHHP..........SRVPLILNmiR.HQVAYNTLIGSCVkrTVlkEDTPGILQFEVCPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.25|      14|     110|     535|     549|       3
---------------------------------------------------------------------------
  535-  548 (25.53/14.37)	DMVKKNLPPASSPG
  557-  570 (26.72/ 9.57)	PMSGTTTPTSTFPG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27711 with Med1 domain of Kingdom Metazoa
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