<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27708

Description Mediator complex subunit 14
SequenceMAPVQLETQQLVPAGGGPAPVPAPAPPAAAPPAASPGYRLSTLIDFLLHRTYAELTVLADLLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQTTLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVIGDDPDVPWRLLKLEILVEDKETGDGRALVHSVQINFIHQLVQSRLFADEKPLQDMYNCLHSFCLSLQLEVLRSQTLMLIRERWGDLVQEERYQPGKCLSLSVWNQQVVGRKTGTASLHKVTIKIDENDVSKPLQISHEPPLPACDSKLTERAMKIDHLSVEKLLIDSVHARAHQKLQELKAILKSYNVNDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQLMLYGIDQQTLDDMEKSVNDDMKRIVTWLQQLKFWLGQQRCKQSIKHLPTVSSETLQLANYATHPVGNLSNYKLFIKLTRLPQYYIVVEMFDVPNNPTQLEYKYYFLSVNYAEGDDNPATAVLLQQFKPNIEELVLDSKSGKQAKGGTKRKLSGDPCPAEPKKPKRSGEMCAFNKVLAHIVAMCDTNMPFIGLRMELSAMEIPHQGVQVEGDGFSHAIRLLKIPPCKGTSEETQKTLDRSLLDCTFRLQGRNNRTWVAELVFANCPLSSTSSREQGPTRHVYLTYESQLSEPVGGRKVVEMFLSDWNSIARLYDCVLEFARSLPEIPSHLNVFSEVRIYNYRKLILCYGTTKGSSISIQWNSAHQKFHISLGTVGPNSGCSNCHNTILHQLQEMFNKSPNVVHLLQVLYDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCQSRGVVAIRDGAYSLFDNSKIVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPQQQQSSKQTGAPGAYPLTSPPTSYLSTVTPSPSMMLSQSPGNLHAASSPSGALRAPSPASFGPTPSPSSLGITMGQSGNFASPHGTIDPSSPYTMMSPSQRPGNWPGSPQVSGPSPAARMPGMSPANPSLHSPIPDASHSPRAGTSSQAMPTNMPPPRKLPHRSWAASIPTILTHSALNILLLPSPTPGLMPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALNPKTNQTLQLKVAPETAGQWKQEELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQASQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTTVSQEAVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAELNSPRPGECTIFAAVRDLMANLTLPPGGRP
Length1440
PositionTail
OrganismAnolis carolinensis (Green anole) (American chameleon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Lepidosauria> Squamata> Bifurcata> Unidentata> Episquamata> Toxicofera> Iguania> Dactyloidae> Anolis.
Aromaticity0.07
Grand average of hydropathy-0.197
Instability index55.74
Isoelectric point8.79
Molecular weight159336.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:Ensembl
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central
stem cell population maintenance	GO:0019827	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27708
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     313.72|     130|     395|     848|    1003|       1
---------------------------------------------------------------------------
  549-  596 (28.58/ 6.99)	NPTQLEYKYYFLSVNY......AEGDDNPATAV.......LLQQFKPNieelvlDSKSGKQ.................................................................................................................................................................................................................................................................................................................................................................................
  848-  944 (126.17/92.08)	.............................................................akggtkrklsgdpcpaepkkpkrsgemcafnkvlahivamcdtnmpfiglrmelsameiphqgvqvegdgfshairllkippckgtseetqktldrslldctfrlqgrnnrtwvaelvfancplsstssreqgptrhvyltyesqlsepvggrkvvemflsdwnsiarlydcvlefarslpeipshlnvfsevriynyrklilcygttkgssisiqwnsahqkfhislgtvgpnsgcsnchntilhqlqemFNKSPNVVHLLqvlydTQAP..LNA...............INKLPTVPMLGLT..QRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCQSRGVVAirdgAYSLFDN..SKIVEGFYP
  945- 1083 (98.64/90.10)	APGLKTFLNMFVDSNQdarrrsVNEDDNPPSPIggdmmdsLISQLQPQ......QQQSSKQ..........................................................................................................................................................................................................................................tgapgaypltspptsylSTVTPSPSMML.....SQSPgnLHAasspsgalrapspasFGPTPSPSSLGITmgQSGNFASPHGTIDPSSP..............................................
 1354- 1414 (60.33/26.18)	.........................................................................................................................................................................................................................................................................................................................................................................LQLT..QKTTVSQEAVSIIV..PIIYDMASGTTQQADIPRQQNSSVA....APMMVSNilKRFAELNSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     177.25|      31|      32|    1095|    1126|       2
---------------------------------------------------------------------------
   13-   32 (35.11/13.14)	.....PAGGGPAP...VP...APAP..P..A.AAP.P
 1095- 1126 (60.17/32.07)	NWPGSPQVSGPSPAArMP.GMSPAN..P..SLHSPIP
 1127- 1161 (42.37/17.52)	DASHSPR.AGTSSQA.MPtNMPPPRklPhrSWAASIP
 1170- 1194 (39.60/15.85)	NILLLP...SPTPGL.MP.GL..AG..S..YLCSPL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.62|      17|      32|     343|     359|       3
---------------------------------------------------------------------------
  343-  359 (28.80/24.05)	LHKVTIKIDENDVSKPL
  374-  390 (27.82/22.94)	LTERAMKIDHLSVEKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.23|      15|     281|     719|     736|       5
---------------------------------------------------------------------------
  719-  734 (21.47/17.92)	PLSSTSSREQGpTRHV
  737-  751 (25.76/ 8.88)	TYESQLSEPVG.GRKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.12|      12|     945|     300|     316|      10
---------------------------------------------------------------------------
  300-  313 (17.00/20.52)	QTLMLirERWGDLV
  322-  333 (22.12/ 8.18)	KCLSL..SVWNQQV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27708 with Med14 domain of Kingdom Metazoa
Unable to open file!