<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27701

Description Mediator complex subunit 12 like
SequenceMRDHGQPSGLLSYEQRPLKRSRLGPPDVYPQDPKQKEDELTAVNVKQGFSNQPAFSGDEHGSARNIVINPSKIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFADLAGNRSLTILAKKVPILSKKEDVFVYLAKYSVPLLRAAWLIKMTCAYYAAISEAKIKKRQAADPNLEWTQISTRYLREQLAKIADFYHMTSSQGSNSVAVPPEVEQALKQWEYNEKLAFYMFQEGMLERHEYLTWILDVLEKIRPADDELLKLLLPLMLQYSEEFVQSAYLSRRLAYFCARRVSLLISDNPNLIATHSPHMIIGPNNPPLAAPSPTTAGSVVNSAQVACSDFLSCPQHRPLVYGLSCMLQTITLCCPSALVWNYSTNENKNINPGSPLDLLQVAPSSLPMSGSSAFNQQVRAKIYEVEQQIKQRGRAVEVRWSFDKCQESTAVGVTISRVLHTLEVLDRHCFDRSDSSNSMESLYHKIFWPNQNKDNQEVAPNDEAVVTLLCEWAVSSKRSGKHRAMAVAKLLEKRQAEIEAERCSEIEVLDEKESISSASLAGSSLPIFQNVLLRFLDTQAPSLSDPNSEYEKMEFVNLVLLFCEFVRHDVFSHDAYMCTLISRGDLSATTASRSRSPTEENMDEQYAREHDVKLEEHSIMEHMYIDAGTANIFDDVDKNDFKAHFGSEFPSEGFSAPLPSRRISINSEKSMKREKVRDLIFPSNYNLLRHLQYATHFPIPLDESSNHECNQRMILLYGVGKEREEARHQLKKITKDILKILNKKSTTEKYNGGELYKVCLLQKSDKFKNVLAGDECQKVRKNKQEAFPTLETVFTKLQQLSYFDQHQVTYQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAVQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRHYHACLILNPDQTAQVFEGLCAVVKHVVNPSECSSPERCVLAYLYDLYVSCSYLRSRFGDLFSSACSKVKQTIYSNVQPSNSNLLWDPEFMLDFIENPSIRSLNYSVLGKILSDNAPSRYSFVCNALMNVCMGHQDAGRINDIANLCAELTACCTVLSAEWLGVLKALCCSSNHVWGFNDLLCSVDVSDLSFHDSLATFVAILIARQCFFLEDVVQHVALPSLLTAACGDPDAEPGARMTCRLLLHLFRTPEVSVLPNVFSGKPFLEIRSSCDRRLLTAAHNSIEVGAVFAVLKAILMLGDAEIGSNSIPSLKKSDYSVRRLLGDLNDDEMWDASSHSLKSCGKPVSIETASLSEYARYVLRSICQQEWVGEHCLKEPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGVKECAEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMIKQCMKESGSGSVAEMNSLLDNIAKATIEVFQQSADLNNNSSNSGIGLFNPKSDLKSGFSSSERQGVWLVAPLIAKLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMQANNELFTTVLDMLSVLINGTLASDLSNASQIGSEENKRAYMNLVKKLKKELGDKCSESIDKVHQLLPLPKQMYDIIACEPMGSLIDTKGNKIAGFDSIDKKQGLQVSAKQKVSPWDLFEGNRNPVPLSWAWFGTVRIDRKVIKYEEQQHLLLYHMHPKPKPRNYYLEPLPLPPEEEEEEEEPITPGSQEPERKSTELLDQGKPSTEEEKKGKGRKRKIKPTPRTDDNVYRVPPNYSPVSSQMMHHHQSALWGYNVMGQPPQTGFFVQNQPVPPANPAKVCPCLPYKLSMWKMARSKTFATTFFNTLCSAQYLGTQIYKVFIFLKQGPTIDQAAIYSQQARPSQLPQYPGMQQAQGKHSMPIYTEIALAIPHGYTMYSTQMSLQSQQSGGLVLSPAYSPRAYQVAHSNPALMERLRQIQQQPSGYIHQQAAAYLQPLTGNQRLSHQALQQNPLVGRALDVMPPTVSHPNLNSIQMPQEQMRHRQQQIQQQRLLQQQQHQNQQQALSLQAMQPQQPL
Length2117
PositionKinase
OrganismAnolis carolinensis (Green anole) (American chameleon)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Lepidosauria> Squamata> Bifurcata> Unidentata> Episquamata> Toxicofera> Iguania> Dactyloidae> Anolis.
Aromaticity0.08
Grand average of hydropathy-0.361
Instability index54.25
Isoelectric point6.82
Molecular weight238503.69
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27701
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.38|      22|     147|     945|     967|       1
---------------------------------------------------------------------------
  945-  967 (34.86/27.58)	CLILNPDQTAqVFEGLCAVVKHV
 1094- 1115 (40.51/27.09)	CTVLSAEWLG.VLKALCCSSNHV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     547.91|     182|     204|    1206|    1409|       2
---------------------------------------------------------------------------
 1206- 1409 (279.82/229.37)	LEI.RSSCDrrLLTAAHNSiEVGaVFAVlKAILMLGDAEIGSNSI....PSLKKSDYSVR.RLL...G.DLNDDEMWDASSHSLKSCGKPVSIETASLSEYARYVLrsicqqewvgeHCLK....EPERLCTDKDLILDPVLSNKQAQKLLQLICYPHGVKECAEGDNPQRQHIKRILQNLDQWTLRQSWLELQLMikqcmkESGSG..........SVAEMNSLLDN
 1415- 1620 (268.08/170.73)	IEVfQQSAD..LNNNSSNS.GIG.LFNP.KSDLKSGFSSSERQGVwlvaPLIAKLPTSVQgRVLkaaGeELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVL...........TCLKgqdeQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQII......TSGTVdmqannelftTVLDMLSVLIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     137.09|      43|      47|    1918|    1962|       3
---------------------------------------------------------------------------
 1918- 1962 (75.85/66.58)	IY.KVFIFLKQGPTI..DQAAIYSQQARPSQL.PQY.PGMQQAqgKHSMP
 1963- 2010 (61.24/45.32)	IYtEIALAIPHGYTMysTQMSLQSQQSGGLVLsPAYsPRAYQV..AHSNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.25|      14|      66|    2015|    2030|      11
---------------------------------------------------------------------------
 2015- 2030 (22.35/17.94)	RLRQIQQQpsGYIHQQ
 2084- 2097 (25.91/13.42)	RQQQIQQQ..RLLQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.85|      65|    1485|     336|     409|      12
---------------------------------------------------------------------------
  336-  409 (96.88/89.74)	PSPTTAGSVV....NSAQVAcSDFLScpQHRPLVYGLSCMLQTitlccPSA..LVWNY...STNENKnINPGSP..LDLLQVAPS
 1822- 1897 (107.96/68.00)	PTPRTDDNVYrvppNYSPVS.SQMMH..HHQSALWGYNVMGQP.....PQTgfFVQNQpvpPANPAK.VCPCLPykLSMWKMARS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27701 with Med12 domain of Kingdom Metazoa
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