Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MSLQDTTKFSNDFITETTTTAADTTTVAANPNTRTTSANHLRASSVSLLAEAVTNGTPSSSEFNRSYDNDSSKDVLSEVRIYDDIITYEKALSRLIDSVDKFKPNLNIAQELIQADKSLFDTLNSFIQYDEIDLHLKALETKASKIDELTQSTLQTLNECHDDLNKLPTLPQIEFELNTILNQRTKINSTILLDYATKLSKFTKIPPTFDKGSIGPNNFIWPAEDSLRRGMLAMASLKADQLTYIPGQAQSMSKEKALPTEVQETQEQTQTQQQDQEEQPRRESFVFSGKNKEEEEETTHTHEDSKRKQEEKDHESGDEDAMDIDLDLFNPDEF |
Length | 334 |
Position | Middle |
Organism | Naumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639) (Saccharomyces dairenensis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Naumovozyma. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.790 |
Instability index | 52.61 |
Isoelectric point | 4.54 |
Molecular weight | 37776.12 |
Publications | PubMed=22123960 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA:EnsemblFungi transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro transcription by RNA polymerase II GO:0006366 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP27689 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 4| 202.94| 45| 92| 124| 169| 1 --------------------------------------------------------------------------- 82- 122 (27.80/12.61) .....YDDIITYEKALSRLIDSVDkfkpnlNIAQELIQADKSLFDT..... 124- 168 (72.18/41.00) NSFIQYDEIDLHLKALETKASKID......ELTQSTLQTLNECHDDLNKLP 169- 203 (39.62/18.11) ....TLPQIEFELNTILNQRTKIN..........STI..LLDYATKLSKFT 217- 259 (63.33/39.06) NNFIWPAEDSLRRGMLAMASLKAD......QLTYIPGQAQSMSKE..KALP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 52.53| 15| 15| 290| 304| 2 --------------------------------------------------------------------------- 290- 304 (26.27/15.60) KNKEEEEETTHTHED 306- 320 (26.26/15.59) KRKQEEKDHESGDED --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 49.50| 14| 15| 5| 18| 3 --------------------------------------------------------------------------- 5- 18 (24.94/14.89) DTTKFSNDFITETT 23- 36 (24.57/14.57) DTTTVAANPNTRTT --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) EKDHESGDEDAMDIDLDLFNPDEF 2) EQPRRESFVFSGK | 311 278 | 334 290 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab