<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27683

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMESSIYRLEELASSFYRIETIDHVNYAQYVPKNMDDQWAIQMELLLRKQNPRNLVALLSRCLWCFSVNDDLLPVLPKLPSANNEDKSPILPEKTGSFTFEYSKPNLPPHYALFLKALRRMIYINLAKASNNRLIQFGNACIPLGKSTNYDILQLEPHLFANGDLVVTLCCKNLNLVPLTENHIEESYLQKHALYMVPSGIRAYLSSNNKSTCLTLPPKNADALLMTLSISHGIKLNDKNNIKWVTVIPDIGHLNGNTPNVASYMDPPTDIRKVIWPLELIYAQPAFDLIGPNNIDIFPSSTVTSSTAMTYNDFQNVLDTIDDFIQLKQTSAYKTPGSSGTNALSSGGAGYTDQFTHYYRNNSVGPHLTDTVSPSLDKLVSSSVSNNNNNNNNIPVNSFNNELLATPPTADTAKGVHANQLFNDKSGIAIDYEPSPTKAELENVKELLMKKDSMNRSSDAQDDVEMHDVNDAQHIKDNDNENINPNDNADDNNDANNNNNGTMSDTNATGNKELFGEDEEEEEEDLFGESNDSVGEGLQSVNKNDPDEITEDMFGMSDDEDGTNITINSRSGDTYFNGDSNALSTPIRKPNLKRKYLDIPVEEMTLTGDSLYTDPGAPLPIETPRDRRKSVFAPLQFNPIIENNVDNKYKNGGKFSFSPFQKDEALQFDISNGDISSSEDEESASDDEDLEFMNIGQETRSVEGTVNEPQYLGYSNVQAVGENLPSSLGSNDLIGTTDANKEGSIWKILQSDIPTTESPLKTVETSVQPVDSIMKSDVNDILKNKISPKITTQEQSPLSGSATLTSNLPEGKTGMPEETPAEIPVSIESSNSLPFLLRHMPLSSLPDKFRQSNPVLQITEESTDILDLISEQIVFDFDQLIKLRVPKSIYRGLKDCKDGLISDIMPKIFTKFERLNGNEIIDKMYTMREPLVFVKKHQELIKIKSDSQPFTKFLGIRPPKGIKNFKFIVLTDSFKDDCTNFVSILSQTYFEHELGFCELLKLTNGNSHGLIYLQNFEQNKLLLLAAQIVSYCSTNKSSEKDVPLMLILPLEVSHPTDLVHKVSVFQTIRNEVKAKIPNKELFLKIVPIDFICNPLVSVDDYSTLAMSIYNILPQKSTRFTTLAPRLPEKVTFKSSQTAPPSSIINYDEYIHLAYSRSIDKCWLFAALTDSTGNENMIKSWYVGNSKKTFDEACNQIWSMAFSLASRKYGKICLILTRLNGVLPDDELMNWRRFSGRNIHLAVVCVDDNTKITFYDRDKLYPSFKPLFKDSKLSGKINFNKFDDYEIRDIDEDIHGALFQHPFPLSNSQHRCAIKSGALVKFKRNSGEGTIDKFEVNLLNCPHADSGKLLESILEEFRNLAALNVWFGVSDGERNSHIPWHVLAVKKMMQSMIHTRIEVQNPPIP
Length1403
PositionKinase
OrganismNaumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639) (Saccharomyces dairenensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Naumovozyma.
Aromaticity0.08
Grand average of hydropathy-0.442
Instability index46.04
Isoelectric point5.01
Molecular weight157418.63
Publications
PubMed=22123960

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi
GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi
GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27683
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     120.92|      30|      34|     571|     601|       1
---------------------------------------------------------------------------
  571-  601 (48.49/30.51)	GDTYFNGDSNALStPIRKPNLKRKYLDIPVE
  607-  635 (48.95/26.58)	GDSLYTDPGAPL..PIETPRDRRKSVFAPLQ
  645-  663 (23.48/ 8.80)	DNKYKNGGKFSFS.PFQKDE...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.17|      27|      28|     504|     531|       2
---------------------------------------------------------------------------
  477-  502 (36.92/22.01)	NDnEN....INPNDNADDNNDANNNNNGTM
  503-  529 (43.19/21.97)	SD.TN..ATGNKELFGEDEEEEEEDLFGES
  530-  556 (38.05/18.45)	ND...svGEGLQSVNKNDPDEITEDMFGMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.29|      19|      28|     747|     765|       3
---------------------------------------------------------------------------
  747-  765 (32.41/19.73)	ILQSDI....PT..........TESP.LKTVETS
  772-  795 (19.00/ 8.20)	IMKSDVndilKN..........KISPkITTQEQS
  802-  829 (18.88/ 8.10)	TLTSNL....PEgktgmpeetpAEIP.V.SIESS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.60|      30|      34|     361|     393|       4
---------------------------------------------------------------------------
  361-  393 (43.23/32.76)	NSVGPHLTDTvSPSLDKlvSSSVSNNN..NNNNNI
  396-  427 (47.37/25.98)	NSFNNELLAT.PPTADT..AKGVHANQlfNDKSGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.44|      38|     238|     837|     922|       5
---------------------------------------------------------------------------
  870-  911 (61.78/111.05)	EQIVF..DFDQLIK.............LRVPKsiyrGLKDCKDGLISDIMPKIFTKF
  928-  980 (55.66/14.43)	EPLVFvkKHQELIKiksdsqpftkflgIRPPK....GIKNFKFIVLTDSFKDDCTNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.06|      29|      34|    1057|    1086|       6
---------------------------------------------------------------------------
 1057- 1086 (42.13/35.48)	LVhKVSVFQTIRNEVKAKIPNKEL.FLKIVP
 1094- 1123 (43.93/30.95)	LV.SVDDYSTLAMSIYNILPQKSTrFTTLAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.35|      16|      16|    1177|    1192|       9
---------------------------------------------------------------------------
 1159- 1175 (23.00/11.90)	KCWlFAALT..DSTGNENM
 1177- 1192 (27.92/15.96)	KSW.YVGNS..KKTFDEAC
 1194- 1211 (22.43/11.43)	QIW.SMAFSlaSRKYGKIC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27683 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FDISNGDISSSEDEESASDDEDLEFMNIGQETRSVEGTVNEPQYLGYSNVQA
2) NKISPKITTQEQSPLSGSATLTSNLPEGKTGMPEETPAEIP
3) SLDKLVSSSVSNNNNNNNNIPVNSFNNELLATPPTADTAKGVHANQLFNDKSGIAIDYEPSPTKAELENVKELLMKKDSMNRSSDAQDDVEMHDVNDAQHIKDNDNENINPNDNADDNNDANNNNNGTMSDTNATGNKELFGEDEEEEEEDLFGESNDSVGEGLQSVNKNDPDEITEDMFGMSDDEDGTNITINSRSGDTYFNGDSNALSTPIRKPNLKRKY
667
783
374
718
823
595










Molecular Recognition Features






MoRF SequenceStartStop




1) IRKPNLKRKYLDIPVEEMTLTGD
586
608