<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27672

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSTELDTSTSKMLKGDGFPNGTGGTVKQNQSGTLEPSNSNTPNTNGNDDSIPSTAATTDPLIHQGNINPQLKSPRASVMSSNANMNDNPDSDLKPNHHHQRYQTPPPIPHVEINQVPMSLIVRNITIFTIKEISQFMKTNLHTDPSSPSSSSSIKKMNFLKLIIFLRNQFLKLYVLIKWTRTIKNNNFNNMIDLLNWFRTTNMLVNNCIWSLKGNLTSMANAKLPNVDLVSALEVLSLGRTNLPTHDFKLSGESNNTFLKIPNDLILKKLKDLNLLVSIKISLMDIPKQFDNDYFIANGRIYLKVENEFQIQLSTIDRHSPLFFVDLNLLLTNFELTVPNKQRLEKLINEILLKNPKPLFALYQFLHKYVITLQLYSINLELSRLENFGKFSGGNLIHSYDSKKCLISIRYWLQNKMKNMGKIIIGVDKKTDNLILKWDNNNAKESKGMSTTYTNISTNLESILDEIMYNHCQLIKSDLLARDIFLEDDENNDVLLFQIPTTCLSMSSIQLKIDLISGVFFFKNPTPFLSNYIQQMNRASSIEELIKVLHRLKLDKIKNILHNMFEKTGWICSKTIKLDRPIKTKLNTTSESQILQHDMFICLPSWPVNWYLIITILSSKSSCVIEKRIGKILSIKGKWELTYLDDTNIATSKLETITYQKVLSLQNTILHRIVNHMLIDSLNQLKIRNKICSGESISSALPSYITKNKLSLSSLSSPSQDKILGDNLRQNNQESNDYTSIITLELESFLEGSKALNGILASSMFLRIDYARSEIRLYAKFKRNTMLIQCQCDDLSIHFVPHDSLAFFLSEKFTNLSLIIHHLTTFRQKLLQLVILTDVVERLHKNFSSNYFKIIELKANEISFKYLKDSSDDQDCTISIITKDQTVQNLTVKLAPSNPQHIIQPFIDASHLDYHFIFSYLQFTSSLFSTFKNILNERDANGNRPVRFTTVNLGLHNLNEYQLVYCNREAGTKITIIIELKNVIHNGRRNLQFYIHFSDDEHITTKSKAYPMMHQVRNQIFMLDTKSIQNGLNNANKLKTDCKYPNAIKLIHGISCDSTDIEPILSEIHDILKIDSNTAK
Length1080
PositionTail
OrganismNaumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639) (Saccharomyces dairenensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Naumovozyma.
Aromaticity0.08
Grand average of hydropathy-0.252
Instability index36.24
Isoelectric point8.99
Molecular weight123627.10
Publications
PubMed=22123960

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
RNA polymerase II repressing transcription factor binding	GO:0001103	IEA:EnsemblFungi
TFIIB-class transcription factor binding	GO:0001093	IEA:EnsemblFungi
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27672
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     836.85|     193|     194|     279|     471|       1
---------------------------------------------------------------------------
  115-  275 (161.16/83.68)	..........................................QVPMSLIVRNITIFTIkEISQFMkTNLH.TDPSSPSSSSSIKKMnF..LK..LIIFLRNQ...FLKLYVL........IKWTR..TiknNNFNNMI..DLLNWFRTTNMLV......NNCIWsLKGNL...............TSMANAkLPNVDlvSALEVLSLGR.....TNlptHDFKLSGESNNTFLKIPNDL..ILKKLKdLNL
  279-  471 (316.15/171.62)	IKISLM..DIPKQFD..NDYFIANGR.......IYLKVENEFQIQLSTIDRHSPLFFV.DLNLLL.TNFELTVPNKQRLEKLINEI.L..LKNPKPLFALYQ...FLHKYVITLQLYSINLELSR..L...ENFGKFSGGNLIHSYDSKKCLI......SIRYW.LQNKM...............KNMGKI.IIGVD..KKTDNLILKW.....DN...NNAKESKGMSTTYTNISTNLESILDEIM.YNH
  475-  676 (229.35/122.37)	IKSDLLarDIFLEDDenNDVLLF..Q.......IPTTCLSMSSIQLK.IDLISGVFFFkNPTPFL.SNYIQQMNRASSIEELI.KV.LhrLKLDKIKNILHN...MFEK...TGWICSKTIKLDRpiK...TKLNTTSESQ.ILQHDMFICLP......S...W.PVNWYliitilssksscvieKRIGK..ILSIK..G.......KWeltylDD...TNIATSKLETITYQKVLSLQNTILHRIV..NH
  677-  820 (130.19/66.11)	...MLI..DSLNQLK..IRNKICSGEsissalpSYITKN...KLSLSSLSSPSQDKIL.GDNLRQ.NNQE..SNDYTSIITLELES.F..LEGSKALNGILAssmFLR..........IDYARSE..I...RLYAKFKRNTMLIQCQCDDLSIhfvphdSLAFF.LSEKF...............TNLSLI.I..........................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.26|      47|     948|      48|      96|       2
---------------------------------------------------------------------------
   48-   96 (76.75/52.38)	DDSIPSTAATTDPLIHQgnINPQLKSPRASVMSSNANMNDNPDSDLK.PN
  999- 1046 (78.52/47.37)	DDEHITTKSKAYPMMHQ..VRNQIFMLDTKSIQNGLNNANKLKTDCKyPN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27672 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MSTELDTSTSKMLKGDGFPNGTGGTVKQNQSGTLEPSNSNTPNTNGNDDSIPSTAATTDPLIHQGNINPQLKSPRASVMSSNANMNDNPDSDLKPNHHHQRYQTPPPIPH
1
110










Molecular Recognition Features






MoRF SequenceStartStop




NANANA