<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27667

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAVDEFDETIGQMIELFKEYKPGVITIDNITKLCHTLGLESFIDDVDATTLRLSTASKIIVIDIDFNKSDGKVKDVKLVLASNFDNFNYFNDDKDRSSTSTTKNILLNSLTLYQDLQVFHHNLQYLYLLDTFSQIDVDTGASASNDVGTGYSETSLSNNNGSINAAITTGKLDLFKYFTELSHYLKQYFNDNSIDSEIKTNLNDKFGIYIISKDDAEVPIAKLYFEKSNDPQHRLYEYIYSTETKSWINESSESFTCGINLIMELITKNPTDEYNSNIWFPQDFISTELIIQKNNTNVNDSSRSSIPIHNGLKPIILLESLAYNFTNSPYQYDQKIQFMNDFTTNLIPITRFNINNDNLELISEIFNWISWMTKILLTTFQLITKIQELGEDNGNEFFTRGTVRHPSVTALRHRRSSHKNKRPSVTESTMFKDERFQQFNLHEIMAEPVIIEEQDSDVVMEVDENDGPTDININNNNNILENSGDQNDQTNTTSNTAIGIDNLGINLNQEMDIDKPEETNIKKGENTISNTGKDNVTEFIMSEDHVSLGKLYTCSFYDDIKEWDLFVEKLKTFLQ
Length575
PositionMiddle
OrganismNaumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639) (Saccharomyces dairenensis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Naumovozyma.
Aromaticity0.10
Grand average of hydropathy-0.493
Instability index34.77
Isoelectric point4.53
Molecular weight65901.48
Publications
PubMed=22123960

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27667
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.40|      26|      48|     461|     487|       1
---------------------------------------------------------------------------
  461-  487 (43.73/27.10)	EVDeNDGPTDININNNNNILENSGDQN
  510-  535 (44.67/23.59)	EMD.IDKPEETNIKKGENTISNTGKDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     198.03|      47|      48|     206|     252|       2
---------------------------------------------------------------------------
  206-  250 (73.78/38.03)	....F..GI....YIISKDDAEVPIAKLYFEKSNDPQHRLYEYIYSTE.....TKSWINE
  251-  300 (41.29/18.37)	SSesFtcGInlimELITKNPTDEYNSNIWF.....PQ....DFI.STEliiqkNNTNVND
  301-  341 (58.54/28.81)	SS.rS..SI....PIHNGLKPIILLESLAYNFTNSP....YQY...DQ.....KIQFMND
  347-  369 (24.41/ 8.16)	......................IPITR..FNINND.NLELISEIF..........NWI..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.71|      17|      98|      77|     106|       3
---------------------------------------------------------------------------
   42-   60 (23.27/22.98)	FIDDVDATTlrLSTASKII
   90-  106 (29.45/ 9.07)	FNDDKDRSS..TSTTKNIL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27667 with Med1 domain of Kingdom Fungi
Unable to open file!