<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27667
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MAVDEFDETIGQMIELFKEYKPGVITIDNITKLCHTLGLESFIDDVDATTLRLSTASKIIVIDIDFNKSDGKVKDVKLVLASNFDNFNYFNDDKDRSSTSTTKNILLNSLTLYQDLQVFHHNLQYLYLLDTFSQIDVDTGASASNDVGTGYSETSLSNNNGSINAAITTGKLDLFKYFTELSHYLKQYFNDNSIDSEIKTNLNDKFGIYIISKDDAEVPIAKLYFEKSNDPQHRLYEYIYSTETKSWINESSESFTCGINLIMELITKNPTDEYNSNIWFPQDFISTELIIQKNNTNVNDSSRSSIPIHNGLKPIILLESLAYNFTNSPYQYDQKIQFMNDFTTNLIPITRFNINNDNLELISEIFNWISWMTKILLTTFQLITKIQELGEDNGNEFFTRGTVRHPSVTALRHRRSSHKNKRPSVTESTMFKDERFQQFNLHEIMAEPVIIEEQDSDVVMEVDENDGPTDININNNNNILENSGDQNDQTNTTSNTAIGIDNLGINLNQEMDIDKPEETNIKKGENTISNTGKDNVTEFIMSEDHVSLGKLYTCSFYDDIKEWDLFVEKLKTFLQ |
Length | 575 |
Position | Middle |
Organism | Naumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639) (Saccharomyces dairenensis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Naumovozyma.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.493 |
Instability index | 34.77 |
Isoelectric point | 4.53 |
Molecular weight | 65901.48 |
Publications | PubMed=22123960
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP27667
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 88.40| 26| 48| 461| 487| 1
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461- 487 (43.73/27.10) EVDeNDGPTDININNNNNILENSGDQN
510- 535 (44.67/23.59) EMD.IDKPEETNIKKGENTISNTGKDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 198.03| 47| 48| 206| 252| 2
---------------------------------------------------------------------------
206- 250 (73.78/38.03) ....F..GI....YIISKDDAEVPIAKLYFEKSNDPQHRLYEYIYSTE.....TKSWINE
251- 300 (41.29/18.37) SSesFtcGInlimELITKNPTDEYNSNIWF.....PQ....DFI.STEliiqkNNTNVND
301- 341 (58.54/28.81) SS.rS..SI....PIHNGLKPIILLESLAYNFTNSP....YQY...DQ.....KIQFMND
347- 369 (24.41/ 8.16) ......................IPITR..FNINND.NLELISEIF..........NWI..
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 52.71| 17| 98| 77| 106| 3
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42- 60 (23.27/22.98) FIDDVDATTlrLSTASKII
90- 106 (29.45/ 9.07) FNDDKDRSS..TSTTKNIL
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