<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27661

Description Uncharacterized protein
SequenceMSSSSKDSVTMEDRSKHVSELLKVLMDINVMNGGNTDTAEKMKLHAKNFESALYAKSSSKKEYLDSMQEKVSAMRNTRDARQKAIDQRTDQMNMQRSQQQQQQQASNNYIPPAKFNNNGNNNPNGNINPQAFMNQQAQARQQAALQLKNRQAVQQQQQQQQRAQLSPQQQQLINQMKIAPIPRELLQKIPNIPQGVTTWQQVTELAQQKRLSPQDMQIAKEMYKIHQQLLLKSKLQQQQQQRTNGNNNDNGLVPNNQMQQQQQQQQQQQQQQRNVPVNSNGNQQRPQNQSRELPNVLGQINQIFSTEEQRALLQEAMEACKNYQRNQFGNANVPDQARQLFIRKYINQKALKKIQTIRMAQQSAAAAANGNIPKSQSNQPVPSQRNNGQQPTPSINGFNGNANMNQVPNPQINNMPPTSNGAPMQNQHQLTPQQRAAQQQRVMQMLQPTPQDIETVRKISSDASRTPLRLSDITNSLSPQEKEEIKRKLQMNQQLFAQVSNYAPQVYVFTKSEGFLKEVLQLRIFVKEILEKCAEGIFVVKLDTVDKLVMKYQKYWESMKLQLLRRQQLIQEQQAQNNQTQGQNNNNNVNGVANPPISQQQQRVQGSMQQIQQQMQQKQWQQTPHLNNNTGTTTPVVSAVPSKSNIPASNYQQMVSSNIGPVMSNKTASATPALSERISPKKEASVKGNRGKSVSKKNSPATATATSGTINQATPSNIVGSKSNTPMVGNFASPLVPNKTSTQQPQNSPSPLTVPVANIANNNNNKMNPYRGEEEKLADLNIKKSEIMSRFKHRREVYGESQIDLFLLTLGDCLGCKDGNMEPIYEIPQIMIDHTNGTGKKKVTKAVQRIRDRDVVNVNVRDNKLIMQSKSKPEDRSYTIDIRDVASVFKNASGLCNLTDMSISPNIKFSEGTNKKKRKLQDVDISPVGSNTSPSSSLMSESKRIKIDSPDDMFMGKTSVNEDTADMDKTNLNVAQNIWDWNYWETVKQ
Length989
PositionTail
OrganismNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Naumovozyma.
Aromaticity0.04
Grand average of hydropathy-0.962
Instability index54.85
Isoelectric point9.83
Molecular weight111584.31
Publications
PubMed=22123960

Function

Annotated function 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
RNA polymerase II activating transcription factor binding	GO:0001102	IEA:EnsemblFungi
TFIIE-class transcription factor complex binding	GO:0001095	IEA:EnsemblFungi
TFIIH-class transcription factor complex binding	GO:0001097	IEA:EnsemblFungi
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of invasive growth in response to glucose limitation	GO:2000219	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi
regulation of establishment of protein localization to chromosome	GO:0070202	IEA:EnsemblFungi
RNA polymerase II preinitiation complex assembly	GO:0051123	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27661
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     185.96|      29|      29|     236|     264|       1
---------------------------------------------------------------------------
   90-  125 (32.50/ 6.37)	....DQMNMQRSQ...........................QQQQQ....QasnnyippakfNNNGNNNPNG
  196-  251 (32.08/ 6.20)	VTTWQQVTELAQQkrlspqdmqiakemykihqqlllksklQQQQQ....Q...........RTNGNNNDNG
  252-  281 (49.36/13.34)	LVPNNQMQQQQQQ..........................qQQQQQ....Q...........QRNVPVNSNG
  563-  591 (38.96/ 9.04)	LLRRQQLIQEQQA...........................QNNQT....Q...........GQNNNNNVNG
  735-  765 (33.07/ 6.61)	LVPNKTSTQ..QP...........................QNSPSpltvP...........VANIANNNNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     343.14|      69|      76|     593|     661|       2
---------------------------------------------------------------------------
  128-  193 (52.28/15.69)	.NPqaFMNQQ.AQ...aRQ...QAALQlKNRQAVQQQQQQQqraqlS.......PQQQQliNQ.MK...IAPI.....PRELLQKiPN....IP...............
  283-  329 (35.04/ 7.96)	..................................QQRPQNQ.....S.......RELPN..VL.GQ...INQIfsteeQRALLQE..A....MEAcKNYQR...NQFG.
  331-  401 (59.47/18.91)	ANV..P..DQ.ARqlfiRKyinQKALK.KI.QTIRMAQQSA.....AaaangniPKSQS..NQ........PV.....PS...QR.NNgqqpTPS.IN......GFNGN
  593-  661 (124.98/48.28)	ANP..PISQQ.QQ....RV...QGSMQ.QIQQQMQQKQWQQ.....T.......PHLNN..NT.GT...TTPV.....VSAVPSK.SN....IPA.SNYQQMVSSNIGP
  670-  734 (71.37/24.24)	ATP..ALSERiSP....KK...EASVK.GNRGKSVSK..KN.....S.......PATAT..ATsGTinqATP......SNIVGSK.SN....TP.......MVGNFASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.66|      22|      22|     898|     919|       3
---------------------------------------------------------------------------
  452-  473 (31.90/20.32)	DIETVRKISSDASRTPLRLSDI
  476-  490 (19.34/ 9.31)	SLSPQEK.....EEIKRKLQ..
  902-  923 (37.42/25.17)	SISPNIKFSEGTNKKKRKLQDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.49|      10|      20|     852|     862|       5
---------------------------------------------------------------------------
  852-  862 (13.30/13.39)	DRDvVNVNVRD
  875-  884 (18.19/12.31)	DRS.YTIDIRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.48|      14|      19|     505|     522|       6
---------------------------------------------------------------------------
  505-  522 (14.34/26.19)	QVYVftK......SEGFLkeVLQL
  523-  542 (17.15/11.07)	RIFV..KeilekcAEGIF..VVKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27661 with Med15 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ELLKVLMDINVMNGGNTDTAEKMKLHAKNFESA
2) EQQAQNNQTQGQNNNNNVNGVANPPISQQQQRVQGSMQQIQQQMQQKQWQQTPHLNNNTGTTTPVVSAVPSKSNIPASNYQQMVSSNIGPVMSNKTASATPALSERISPKKEASVKGNRGKSVSKKNSPATATATSGTINQATPSNIVGSKSNTPMVGNFASPLVPNKTSTQQPQNSPSPLTVPVANIANNNNNKMNPYRGEEEKLAD
3) KKIQTIRMAQQSAAAAANGNIPKSQSNQPVPSQRNNGQQPTPSINGFNGNANMNQVPNPQINNMPPTSNGAPMQNQHQLTPQQRAAQQQRVMQMLQPTPQDIETVRKISSDASRTPLRLSDITNSLSPQEKEEIKRKL
4) KLQQQQQQRTNGNNNDNGLVPNNQMQQQQQQQQQQQQQQRNVPVNSNGNQQRPQNQSRELPNVLGQIN
5) QEAMEACKNYQRNQFGNANVPDQARQLFIRKY
6) YAKSSSKKEYLDSMQEKVSAMRNTRDARQKAIDQRTDQMNMQRSQQQQQQQASNNYIPPAKFNNNGNNNPNGNINPQAFMNQQAQARQQAALQLKNRQAVQQQQQQQQRAQLSPQQQQLINQMKIAPIPRELLQKIPNIP
20
572
352
234
314
54
52
779
489
301
345
193










Molecular Recognition Features






MoRF SequenceStartStop




NANANA