<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27654

Description Uncharacterized protein
SequenceMPPSKYILTPPDDLYPYISNNEHDQSHTKKIYPDFEPWTHTKEEDQILNNFISKGYYTTSKVNFESISARSSLNESLPKVSTQLAIQLSKVLQIRENEINKIPSDDVKNEPSSHKHSKISIFSGPSFSLPDRITLTDHRKEVWLQELSSPYVSLSKISKHIPHGLKRRQVLEQCYLKQIPLERAIWLIKCCYSMEGKVLAMKNKGSQEEIDKQLFKEWTENFVYILEKLVFEMTQHYNDSNKLKTWKIEVFYFLKLLGNCYTLELIDKEIFHHWLVEFVAKVENFEFIPLTLHMLTIFWDGICKPLGTKGNTEMLSNQSLFLISKMTDMLLQKYSTIYQSRSMINDEKYIINDIKKNNKLKESMLSILGTLIGKLFQEQTLEAFLFPSTSWDLYKPHLYEIMNSLEVSPEVALEIKKKLELVSYSNESLKMNPWLDNHTNENTNNDEDSSVIKMNNANMNLAIIQMNGIDTKFTEILDDNPTDFDWASYVDQHILQINQLMQLVLWAIHPSRQHHYESHQLVAKLLLLKINSIEGIQEFEIEDSIWTLVFKIAKLSNTNKMLHVALSSLYNLLNILITYGILKVPTYIRKLISSGVLYLPESNDKFIHCNILINLKISPLMKSQYNMVLRNVMEYDVTYYERFNFEQLQKDAEEIKSKILKSEPLNLSTYPLSVRTMVAEWYLSHLCSDVLSPVDNNILVKNFQIFCVHLKLFHHYYKWIEFIVYHQLLSNIIALETLMDILLCYEKLFSQFINDHILFTKTFIFTYSKVLKEKDPDVYKVISFAAFWKFFMKNFSLVLNIDNDLRTELSVVYEEEKTKHENLHMNKHEALDIYHAINNINPEEKDEHWNFTEAFQTNIKNLLNLTNDNSNEELTFRINLLLLMVVNNREYNKFMSIFLKRKDFKNENLIRLISFKLLTFEQIQNILGITFVLPFLVNENIKGSLYFESHRRKYIKDNYVKILNACESDMDAFYETFLAIVVNFGTSKKLSDSTTKLLIDLFKNNRSTSTHIMEDLLHYGFPKETHELEDDNTLDDSKPVELYSRLDFLNLWIFQSFTAYQIQELLTEYTEPHRSEQELKLFLFDIIELTGPNELSAQLFEKVIHVPTIEIIIKIFEEDFFQRCLTGSDVSREYLATIVELASSLSQKIQKDESRNTPMSETCFRSFQRIMSSFANEDSKKLHTSEPMIDVYLKLFSIHQNSIFEHILNSVQDRRTSEPCHAFIDDMFTLFDRVTFSLRLKLMLYEILSSLKSYSIYASTTGNETGNVKLTIPPKLLQVPPFQVSSFIKEEEDIEDPEELDLGITTTEEHGEYAERNKWFLYDKKEKLYTSPFKSEPYHNITNYQPDTAGSFNNTCLNLSLFNASFERKNPR
Length1372
PositionKinase
OrganismNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Naumovozyma.
Aromaticity0.11
Grand average of hydropathy-0.303
Instability index43.05
Isoelectric point5.69
Molecular weight161191.97
Publications
PubMed=22123960

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by galactose	GO:0000411	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27654
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.42|      13|      19|      13|      25|       1
---------------------------------------------------------------------------
   13-   25 (25.25/13.53)	DLYPYISNNEHDQ
   34-   46 (26.17/14.29)	DFEPWTHTKEEDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.63|      15|      19|     159|     175|       2
---------------------------------------------------------------------------
  159-  175 (24.18/27.94)	KHIPhgLKRR.QVLEQCY
  177-  192 (26.45/20.04)	KQIP..LERAiWLIKCCY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.94|      15|      19|     486|     503|       3
---------------------------------------------------------------------------
  486-  500 (28.21/20.58)	WASYVD.QHILQINQL
  506-  521 (26.73/10.52)	WAIHPSrQHHYESHQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     654.57|     232|     263|     773|    1035|       4
---------------------------------------------------------------------------
  725-  850 (125.65/73.47)	....................................................................................................................................YHQL............LSNIIALET...........LMDILLCYEKLFS.....QFIND..H......ILFTK.TFIFTYSKVLKEKDP.DVYKVISFAAFWKFfmKNFSlVLNIDnDLRTElsvvYEEEKTKHENLHMNKHEALDIyHAINNINPE..EKDEHWN
  851- 1107 (339.51/208.28)	FTEAFqtnIKNLLNlTNDNSNEELTFRINL...LLLMVVNNREYNKFMS..IF..LKR..KDFKNENlirliSFKLLTFEQIQNIlgitFVLPFLVNENikgSLyFEsHRRKYIKDNyvKILNACESDMDAFYETF............LAIVVNFGTSKKLSDSTTklLIDLFKNNRSTST.....HIMEDLLH......YGFPKETHELEDDNTLDDSKPvELYSRLDFLNLWIF..QSFT.AYQIQ.ELLTE....YTEPHRSEQELKLFLFDIIEL.TGPNELSAQlfEKVIHVP
 1116- 1301 (189.41/87.55)	FEEDF...FQRCLT.GSDVSREYLATIVELassLSQKIQKDESRNTPMSetCFrsFQRimSSFANED.....SKKLHTSEPMIDV....YLKLFSIHQN...SI.FE.HILNSVQDR..RTSEPCHAFIDDMFTLFdrvtfslrlklmLYEILSSLKSYSIYASTT...........GNETgnvklTIPPKLLQvppfqvSSFIKEEEDIEDPEELD.................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.89|      18|      19|     249|     266|       5
---------------------------------------------------------------------------
  249-  266 (30.85/20.69)	EVF..YFLKLLGNCYTLELI
  269-  288 (26.04/16.15)	EIFhhWLVEFVAKVENFEFI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.43|      46|     935|     384|     433|       9
---------------------------------------------------------------------------
  384-  433 (66.36/50.92)	FLFPSTSwDLY....KPHLYEimNSLEVSPEVALEIKKK.LELvSYSNESL.KMNP
 1320- 1371 (69.07/37.75)	FLYDKKE.KLYtspfKSEPYH..NITNYQPDTAGSFNNTcLNL.SLFNASFeRKNP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27654 with Med12 domain of Kingdom Fungi
Unable to open file!