<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27651

Description Uncharacterized protein
SequenceMNNGNDRIPNPYQKQFSNQQQYSQQIPSQQQQQQFPTGRDLWQGQSIRNQPQLHVQQHPVVNKKRMTGNTLSTTGTMHGKTPMLMANNDVFSIEPYKARKDSARVSVIEKYEIIGYIAAGTYGKVYKAKRSNSIDVMDNNTIIPSNSTDSSTTESSLFNQNTENTMIPDQIRSTQQQLLKSGSHSIENDKIMNMNNTDNNTTNNGNNNINTILTQKNGTSVRKKVSSTYYAIKKFKTEKEGVEQLHYTGISQSACREMALCRELNNKHLTQLVEIFLERKSIYMVYEFAEYDLLQIIHFHSHPEKRMIPPMMVRSIMWQILDGVSYLHQNWVLHRDLKPANIMVTLDGCVKIGDLGLARKFYNMLQTLYTGDKVVVTIWYRAPELLLGARHYTPAIDQWAVGCIFAELIGLQPLFKGEEAKMDAKKGVPFQANQMKKILQVLGSPTQKNWPNLQKYPEYEQLSKFPKFKDKLPGWYHSAGGRDKDTLDLLYRLLSYDPIQRIDALDALDHPYFTNGDSPVCENVFEGLNYKYPARRIHTNDNDIINLGIHRNKHTSQQTQSNPTNTSTSTTLGGLGVNRRILAAAAAAAAAVSQPGSRTTEPARKRRR
Length608
PositionKinase
OrganismNaumovozyma castellii (strain ATCC 76901 / CBS 4309 / NBRC 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Naumovozyma.
Aromaticity0.08
Grand average of hydropathy-0.661
Instability index43.66
Isoelectric point9.43
Molecular weight69182.69
Publications
PubMed=22123960

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IEA:EnsemblFungi

GO - Biological Process
negative regulation of filamentous growth	GO:0060258	IEA:EnsemblFungi
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
nuclear-transcribed mRNA catabolic process, non-stop decay	GO:0070481	IEA:EnsemblFungi
phosphorylation of RNA polymerase II C-terminal domain	GO:0070816	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi
protein destabilization	GO:0031648	IEA:EnsemblFungi
response to oxidative stress	GO:0006979	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27651
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.06|      20|      23|     139|     160|       2
---------------------------------------------------------------------------
  139-  156 (26.68/14.96)	.....NNTIIPSN..STDSSTTESS
  159-  182 (22.70/15.58)	NQ.ntENTMIPDQirSTQQQLLKSG
  183-  203 (20.68/ 6.18)	SHsieNDKIMNMN..NTDNNTTN..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.73|      13|      27|      96|     109|       3
---------------------------------------------------------------------------
   96-  109 (16.87/16.92)	YKARKdSARVSVIE
  126-  138 (22.87/16.49)	YKAKR.SNSIDVMD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.79|      10|      22|     209|     218|       4
---------------------------------------------------------------------------
  209-  218 (16.97/10.12)	INTILTQKNG
  232-  241 (16.82/ 9.97)	IKKFKTEKEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.60|      15|      27|     305|     323|       5
---------------------------------------------------------------------------
  305-  323 (19.63/27.17)	KRMIPPMmvrSIMwQILDG
  334-  348 (27.97/17.80)	HRDLKPA...NIM.VTLDG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27651 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DIINLGIHRNKHTSQQTQSNPTNTSTSTTLG
2) GSHSIENDKIMNMNNTDNNTTNNGNNNINTILTQKN
3) MNNGNDRIPNPYQKQFSNQQQYSQQIPSQQQQQQFPTGRDLWQGQSIRNQPQLHVQQHPVVNKKRMTGNTLSTTGTMHGKTPMLMANNDVFSI
4) SIDVMDNNTIIPSNSTDSSTTESSLFNQNTENTMIPDQIRSTQQQLLK
543
182
1
133
573
217
93
180










Molecular Recognition Features






MoRF SequenceStartStop




1) RILAAAAAAAAAV
2) RIPNPYQ
3) SRTTEPARKR
580
7
597
592
13
606