<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27641

Description Mediator of RNA polymerase II transcription subunit 11
SequenceMAQPSQSSVPESDAGSFPVDIHKPFTPAERIQQLGEIDNDIASLLQHLSAALKALATPPGKRIFQEQDSESNSPSASDTSNPNDTPPSSCGIDPVTAFKTAQNDFFRTIDRIDKHLTRQIYALEEAGIITLKSGTGSGAGTVGAGATEEQAQQLPQPQMIPGQPQAAGITADASVAPVPKARLEPDGMGRYGKLDVGRLNMASSIVEREMEGELWRKAREHLGRMTSQASGREDRMEE
Length238
PositionHead
OrganismChaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.04
Grand average of hydropathy-0.602
Instability index47.09
Isoelectric point4.95
Molecular weight25477.03
Publications
PubMed=21784248

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364147
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27641
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.03|      22|      23|     182|     204|       1
---------------------------------------------------------------------------
  182-  204 (35.41/23.34)	RlEPDG.MGRYGKLDVGRLNMASS
  208-  230 (35.61/19.37)	R.EMEGeLWRKAREHLGRMTSQAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.27|      14|      21|     144|     158|       2
---------------------------------------------------------------------------
  144-  158 (21.07/15.18)	AGATEEqAQQLPQPQ
  167-  180 (24.19/12.75)	AGITAD.ASVAPVPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.33|      25|      29|      31|      59|       3
---------------------------------------------------------------------------
   31-   59 (32.68/27.35)	IQQlgEIDNDIASllQHLSAALKALATPP
   63-   87 (45.66/25.05)	IFQ..EQDSESNS..PSASDTSNPNDTPP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27641 with Med11 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ATPPGKRIFQEQDSESNSPSASDTSNPNDTPPSSCGIDPVT
2) EMEGELWRKAREHLGRMTSQASGREDRMEE
3) KSGTGSGAGTVGAGATEEQAQQLPQPQMIPGQPQAAGITADASVAPVPKARLEPDGMGR
4) MAQPSQSSVPESDAGSFPVDIHKPFTPAERIQQ
56
209
132
1
96
238
190
33










Molecular Recognition Features






MoRF SequenceStartStop




1) GSFPVDIHKPFTPAERIQ
2) LWRKAREHL
3) PGKRIFQE
15
214
59
32
222
66