Description | Mediator of RNA polymerase II transcription subunit 5 |
Sequence | MVTVTDPLTARLEAAIKAWSDFFSDAEHERLDPAIFADQSQTLFANHPLAPVPLADLLLRPTPSNRECVDQRTLQYLQVLQKQGRITTAAVLRALYKYSTAHTRAQTPDGKPKHGAGDSSTNDADVGGSSKADLTSRMVRWRNSYMVEEDVLWRLARAVNHGTGIKTSHDVTEVAKVLARWTALFAEVSAAISRDAFNSMNGLQVKDESEDARNAFVLFYFAFCENQLVNETLSQPVCKDICRKLLDSLDAFLPTLMHLTADITGRLEHFRSEVLARYAPQEKKSMDMPSFMNDLSMSLESFQVPELPVVNTRAGLYIYLGAALVGRPMIDDEALFSYLHNRYQGDLQAMAVHLILASFDLLANAVFRNEGAKTGHLLKSFLINKVPLILVQLVAYAATTMYPFNAEMCITEALNQVDINMFPTLSGMFDMPNNNSFNDSVRQDFCFACQLHGLLSQAAIETLLGDITYQSLPPEGRYVKEQLVQACLQEPDRTLKLIGELDNMNGNVGAAAQAIVEICRDLASKPLSLDVLLLFDKPHKILHPLCELLDNWAGYEEDHGEYQPVYEEFGSVLLLLLAFVYRYNLSTADLGIRSSGSFVAKLLNGVDRCQPLEQLSEQEKSHLGGWIHGLFDTEAGGLGDELMSSCPPQDFYLLAPTLFHQIVNALSAGYLTDEMLKGGLEYLVDVLLLPALVPALLYLSNLLWADNQPIQNAVIKILQPILKPTSISNEASTMLSSVLNIVAKPLEHALKSYQRQDPECQKIEPLLLAIADNLAVSRRTGGADHTELESWCSAQITNPATGALIHGGLAAAVRTTIQQLVQWAQNPTLNSMNGMPAPYTHRQTLAAQQILGPHRLLGIILDELKSSPEPGIAYDVVTTMICAPDVRNSTISSPSTQSNNSSDHNDQAQNHQSQDAKHKHPHRLTLRDALRLEAHDFRAHLRADPVLAETVVRLYRRVEAQLTPLALPLPPAAAAAPAVGVNVGVDAATAAAAAAAAAMMPDALGLGVVGGVELGGMEGAIAAAVAAANGSGTGGAGGDGTQGGAGDAGMGLDGQQQGQGGSSAGDMGLGGGTADDIFSGLSGPDDFGADFGSWSMDLS |
Length | 1099 |
Position | Tail |
Organism | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.047 |
Instability index | 38.29 |
Isoelectric point | 5.00 |
Molecular weight | 118675.43 |
Publications | PubMed=21784248 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP27639 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 125.59| 32| 34| 986| 1019| 1 --------------------------------------------------------------------------- 987- 1019 (38.57/24.61) .AATAAAAAAAAAMMpDALGLGVVGGVeLGGMEG 1024- 1043 (35.44/14.64) AV......AAA.....NGSGTGGAGG...DGTQG 1053- 1083 (51.57/24.49) DGQQQGQGGSSAGDM..GLGGGTADDI.FSGLSG --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 93.05| 29| 33| 635| 666| 2 --------------------------------------------------------------------------- 635- 666 (46.45/33.22) AGGLGDELMSSCPPqdfYLLAPTLFHQIVNAL 668- 696 (46.60/25.22) AGYLTDEMLKGGLE...YLVDVLLLPALVPAL --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 65.55| 23| 29| 791| 819| 3 --------------------------------------------------------------------------- 791- 819 (28.01/33.50) WcsAQitNPATGALihGGLAAAV..RTTI..QQ 823- 849 (37.55/20.70) W..AQ..NPTLNSM..NGMPAPYthRQTLaaQQ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 62.07| 19| 35| 248| 271| 4 --------------------------------------------------------------------------- 248- 271 (25.73/26.74) SLDafLPTLMHltaDITGRLEHFR 285- 303 (36.34/20.67) SMD..MPSFMN...DLSMSLESFQ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 103.57| 31| 35| 354| 387| 5 --------------------------------------------------------------------------- 352- 376 (27.80/20.16) ........VHLIL...asFDLLANAV.....FRNEGAKTGH 378- 413 (44.48/28.37) LKSFLINKVPLIL.....VQLVAYAAttmypFNAEMCITEA 414- 442 (31.30/13.66) LNQVDINMFP...tlsgmFDMPNNNS.....F.NDSVR... --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 40.73| 12| 29| 712| 723| 6 --------------------------------------------------------------------------- 712- 723 (20.09/14.72) NAVIKILQPILK 740- 751 (20.64/15.33) NIVAKPLEHALK --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.26| 13| 29| 570| 582| 7 --------------------------------------------------------------------------- 570- 582 (21.71/14.24) GSVLLLLLAFVYR 596- 608 (22.55/15.11) GSFVAKLLNGVDR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 61.18| 18| 29| 931| 948| 9 --------------------------------------------------------------------------- 931- 948 (30.95/18.25) RLEAHDFRAHLRADPVLA 957- 974 (30.23/17.63) RVEAQLTPLALPLPPAAA --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 130.46| 37| 37| 151| 187| 10 --------------------------------------------------------------------------- 114- 157 (38.13/26.89) .....HGAGDSSTNDAdvggsskADLTSRMVRWRNSYmveEDVLWRLAR 158- 194 (58.96/46.39) AVN..HGTGIKTSHDV.......TEVAKVLARWTALF...AEVSAAISR 196- 225 (33.37/22.43) AFNsmNGLQVKDESED.......ARNAFVL..FYFAF...CE....... --------------------------------------------------------------------------- |
IDR Sequence | Start | Stop |
1) GTGGAGGDGTQGGAGDAGMGLDGQQQGQGGSSAGDMGL 2) RNSTISSPSTQSNNSSDHNDQAQNHQSQDAKHKHPHRLTLRDA | 1032 887 | 1069 929 |
MoRF Sequence | Start | Stop |
1) FGADFGSWSMDL | 1087 | 1098 |
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Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab