Description | Mediator of RNA polymerase II transcription subunit 7 |
Sequence | MDSSEDDGNKVAHLWPDPPAFWKDFTPENIERYNALKQTYAQQHGLSSDALVRIPDVPADLINLQPPPEPVDGKWKLYGQQEALANSLQSLEDAGIQRLAPASETTSDSKHFDRGFELKKLAKSLLVNYLELMGIMSINPAHASEKVQDIKTIVLNFHHILNEYRPHQAREQLIQLMQDHLDAKRNETAAVRAVVDKAKRLIEGLASIEIPKVEDDNGRKAVEVERAALAERREIAAWQEADALFT |
Length | 246 |
Position | Middle |
Organism | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.538 |
Instability index | 49.13 |
Isoelectric point | 5.23 |
Molecular weight | 27700.90 |
Publications | PubMed=21784248 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery.
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364060 ECO:0000256 ARBA:ARBA00003669 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP27637 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 3| 107.87| 32| 38| 66| 103| 1 --------------------------------------------------------------------------- 40- 64 (12.66/13.98) ......YA.QQHGLsSDAL..VRIPDvpADLINL...... 72- 103 (56.53/30.79) DGKWKLYG.QQEAL.ANSL..QSLED..AGIQRLAP..AS 108- 144 (38.69/17.54) DSKHFDRGfELKKL.AKSLlvNYLEL..MGIMSINPahAS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GKWKLYG 2) KVAHLW | 73 10 | 79 15 |
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