<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27635

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEARAHGALPNNYDRERFINGVGGDDKALKRKLEEPLSDITKELDTVIAQSDVAVADPKGQLCPDADVPDEMEHITDGILPLNLLLIRLAEFSHSKLEELVTMLASKPVPQHAVNGNGSHSTLVEDASPESQEKKRLLLNTIQDLHSRWVKALVITEWARNAEKVGKLIDIRTHLFKKLELYPQVLNDFINLKRDMAWAKVPSPDLKTALHILTHGEVTWMPDFNFLDPPPLTTEETLRWINDMNLALHARLQLEEHDKLPPPFKNYTIDSGRVTFRVRGEFEVDLSISEEDFSEQFWFINFRFDFSPAPAELTPAVRYWMTEKVNNILKTEGLGGCYKYLHEFTLTQKIAELHRQAIALNKGRWANSLRVEKLNRNLGIHYWANRLHSQNLKSWIIIGVHSGEDPQGLEEPKPSYLMVQWFREGVEQFIDIPFSQEKLSIEEILEFVTAKHVGYLLFSLFRKFDGKPRFTQGKKARLELNVWTQKPEDYYLSMQLLDDEDLKIQVNPWMGDFITTPSTGPWNRTLNSLGNPAEEGSKELENFRYIYIISVLKAQGKSHGWSVVRSPISQDELRSIVHSESASSRETFQAAWTRFVDWDPQWYAMRSMSLAGDQWWLVEVTSQRQSISGNRLVFFTKMAPCFSEERLTDGFFNGLRDHSRRLIAEITNLRELYPGITPSQLRKLIDPTRQPPVLPVKASKILGDFGGADAQSIAWLKDPVWLIYRGSACDTRVSDSPQQKRTQPVLDVFEAYLDVTDRRRFQTLNPRLDRDILYNPYTGRFMFRLRAKMGVPVVPLLGIRVRQLQRLLDFLEGLRRVGDQAVPERVTLREIVFSYGATRKRDSTNQPKVRPWRVRLDLTKEEGVGVVLEKGNPHLRVINRLEDLVNSQKFYSLATYLTLSLPLFRAFEQLENAWQTAQENGRGSCFILHLSLDKHTIRFVLPGHQRQISLLIQPHEKEGKLVWEVGRPRHDPELLNENCEFNRVLKERVWTISGSGFKGLVTGAAAEPDEGIERLLVLISDAVLHLSTSQPATAPPQPPQAQPSQQVQQVQQQQVVSQLQPQAQQPRSAMPHASVGQQQPHGAPAPMARFPPQQQQIFQQQRPPQPQPNMHGGQISQPNMHGGPKPQLQGQHGQPGQMVAAPQQQGQRPGTGTAAGMGRSNAPLVVLD
Length1168
PositionTail
OrganismChaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.08
Grand average of hydropathy-0.481
Instability index47.39
Isoelectric point7.46
Molecular weight133067.04
Publications
PubMed=21784248

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP27635
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     207.66|      47|      68|    1037|    1089|       1
---------------------------------------------------------------------------
 1038- 1089 (87.39/54.61)	PPQAQPSQQVQQVQQQQvvsqlQPQAQQPRSAMPHASVGQQQPHGAPAPMAR
 1092- 1127 (65.05/33.70)	......PQQ.QQIFQQQ.....RP..PQPQPNMHGGQISQPNMHGGPKP..Q
 1130- 1159 (55.22/28.78)	GQHGQPGQMVAAPQQ.........QGQRP.............GTGTAAGMGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.98|      42|      70|     770|     814|       2
---------------------------------------------------------------------------
  770-  812 (69.89/48.29)	RDILYnPYT...............GRFMFRLRAKMGVPVVPLLG.IRVRQLQRLLDFLE
  829-  886 (58.09/29.81)	REIVF.SYGatrkrdstnqpkvrpWRVRLDLTKEEGVGVVLEKGnPHLRVINRLEDLVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.12|      22|      24|     942|     965|       4
---------------------------------------------------------------------------
  942-  965 (36.31/28.38)	PGHQRQisLLIQPHEKEGKL...VWEV
  968-  992 (36.81/22.25)	PRHDPE..LLNENCEFNRVLkerVWTI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     126.11|      24|      98|     205|     232|      10
---------------------------------------------------------------------------
  205-  232 (41.06/31.95)	DLKTalhiLTHGEVTWMPD..FNF.LDPPPL
  234-  252 (21.17/ 6.91)	.........TEETLRWIND..MNL.ALHARL
  253-  264 (21.16/ 8.07)	QLEE......HDK............L.PPPF
  292-  310 (22.79/ 9.27)	DF.........SEQFWFIN..FRFdFSPAP.
  313-  334 (19.94/ 6.01)	........LTPAVRYWMTEkvNNI.LKTEGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     110.53|      33|      33|     433|     465|      11
---------------------------------------------------------------------------
  433-  457 (35.36/23.75)	..............P.FSQEKLSIEEILEFVTAKHVGYLL
  458-  492 (48.31/35.78)	FSLFRKFD....gkPrFTQGKKARLE.LNVWTQKPEDYYL
  494-  520 (26.86/15.86)	MQLLDDEDlkiqvnP.W.........MGDFITTPSTG...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      30.93|      10|      27|    1000|    1009|      12
---------------------------------------------------------------------------
 1000- 1009 (17.48/12.05)	LVTG..AAAEPD
 1026- 1037 (13.45/ 7.14)	LSTSqpATAPPQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27635 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LSTSQPATAPPQPPQAQPSQQVQQVQQQQVVSQLQPQAQQPRSAMPHASVGQQQPHGAPAPMARFPPQQQQIFQQQRPPQPQPNMHGGQISQPNMHGGPKPQLQGQHGQPGQMVAAPQQQGQRPGTGTAAGMGRSNAPLVVLD
1026
1168










Molecular Recognition Features






MoRF SequenceStartStop




NANANA