<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27633

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDAGEYETNTLLIVSTRFPRSNLSAISFRIYEPIASQSIYTFNASDVEDALRNDGLLVYMDAVRRGIWCFYLSSNDPSTTTHPEQLGLHARMEVCGYPLGLVANGSFEPVGLFRNRPLGPNAINTPTSSSSTNSAVEVKFSFDGKAAPIPSQDFKGYSTVPVREIYEFFVKAVLSSLTTFFCRNSGAILLNHRTVLLPSTAFASGDADWNQIPKQAAVGTFRTHLTTTGSLLISLHVSLLHGMVSSADVLRSSLLSASSTVLAAPFGTFGTLQGVISTDETQAGESGSFGQYPETQVTRMRQNHTERFIQWKNTCYTLLQMKGMSPSLLDGSPWLNIHFTQRKPYDYRPDGKRTPLSSSGPTAPWPAVLCFRKPKLESMADVPFEKAFNATGIESMDPLNKAKVWCEGVSEREEALARRKKERDITAAQDHAQLADQKGQSQTNGLSPMGAWRPANGVVAGSTAGAMYPTPPDGVQQIGAAAFDAAQMQSPSGQLPSNNIAGVGDQATQVTAGQAQGQASALAPAPAAVTEPAFNSTNFPEESYYGDLGENLFEGNELTEADFENIFDEQPTSMDLYMPMLDGEPAQPAVQDNSQNQGGMEGVQMTPSQEEQGASSKPLPPVFAARPDLRPPNNNTLVNQQALQQSNTENFNRNSAIGIKRHPSPFNPETVFKRICPAFSRPPPVPLAQRSLPSRQSARHNSVFEPIEFDPSLALTSKKYGEHGLFDYRSALKNKESDAFFNVSPASTSFPTNVRQCKSQNNPPQDFGSILVKLAAGHANGSVSQKDVFSDSESSTWTSDDDEHAANDASGRASSPAKSSVLQRRRPDDDVVSIAASFRELDHLSADSPGYGPVDIARLSTAEIPELSLSRYFADPEPAPLRLSVSDADFITVAQILTEQAASGFLKLPAERPYSDLQDARRSLVKAIRYSVRGLHKALPRTLSGAVGCQLRPLAEVQDVPLMQPIGRVQVRANEVSKSSIFSIPVPHVELRRYDNQLSVLPSAVSFWETLGLGPVQGPKDIVAVCVVPQVEGMRENAAAFLDRVQSTYEVLRLGSFDRLPTSGNVVDGLVLLVTDQDVGSPGLSMNMQRSAFSHPMAKVALACASAQITEKNIVVFFAYTPEKPGSIVDACSAFQELFEHYKRFLVEKKKPVANELALQLIPLDYIVSETGLVVLTPSECARLCIETYDRCTLFGGPMPSPAILLEKALPRAIDFKLAATPSPNLLRENQCIHIAYARSIDERWVTAAWTDNRGSNQAIASYCLGRRGRPLSRPFSDVVHEIWETTQAIISTCKVHWRVIITKCGPMDPHEIELWAARAQAETRSNVSLVLLTVDTDPSLQLIPPAATIPTSAPSVFYSTPVSTPQPMSSMSPGENPPTPSGFGGSSFTPGGGGAGESSQTPGSQPQSQQQQQIDLTAGADGETTLIDPSEMTHGVLLSHRLNNSPSLTDLNPALASGYLIKRGGPRPEDLPVAMEGVRDAGKG
Length1485
PositionKinase
OrganismChaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.07
Grand average of hydropathy-0.297
Instability index51.59
Isoelectric point5.49
Molecular weight160608.73
Publications
PubMed=21784248

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27633
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.34|      28|      39|     986|    1014|       1
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  986- 1014 (46.32/34.05)	VPHVELRRyDNQLSVLPSAVSFWETLGLG
 1028- 1055 (49.02/30.71)	VPQVEGMR.ENAAAFLDRVQSTYEVLRLG
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     474.76|     148|     613|     665|     826|       2
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   18-  190 (185.75/104.56)	FPrSNLSAISFRIYEPIasqsiyTFNASDVEDALR..NDGLLVYMDAVR.RGIWCFYLSSndPSTTTHPEQLGLHARMEVCGYPLG..LV......ANGSFEPVGLFRNrplgpNAINTPTSSSSTNSAVEVkfsfDGKAAPiPSQ....DFKG.........................ystvpvreiyEFFVKAVLSSLttfFCRnSGAILL
  197-  253 (67.91/27.47)	LP.STAFASG...........................................DADWNQI..PKQAAVGT.FRTHLTTT......GSLLISLHVSLLHGMVSSADVLRS.....S..................................................................................................
  692-  881 (221.11/126.72)	LP.SRQSARHNSVFEPI......EFDPSLALTSKKygEHGLFDYRSALKnKESDAFFNVS..PASTSFPTNVRQCKSQNNPPQDFGSILVKLAAGHANGSVSQKDVFSD.....SESSTWTSDDDEHAANDA....SGRASS.PAKssvlQRRRpdddvvsiaasfreldhlsadspgygpvdiarlstAEIPELSLSRY...FAD.PEPAPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      70.92|      17|      17|     912|     928|       3
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  912-  928 (29.59/16.72)	RPYS..DLQDA.RRSLVKAI
  929-  947 (16.88/ 6.08)	R.YSvrGLHKAlPRTLSGAV
  952-  966 (24.45/12.41)	RPLA..EVQDV...PLMQPI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.60|      14|      17|     364|     379|       4
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  364-  379 (24.49/19.70)	PWPAvlCFRKPKLESM
  383-  396 (24.11/12.76)	PFEK..AFNATGIESM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.82|      24|      27|    1355|    1378|       6
---------------------------------------------------------------------------
 1355- 1378 (48.22/23.27)	PSVFYS...TPVSTPQPMSSMSPGENP
 1381- 1407 (42.60/19.65)	PSGFGGssfTPGGGGAGESSQTPGSQP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.23|      35|      40|     447|     486|       7
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  430-  483 (49.13/43.14)	DHAqladqkgqsqtnglSPMGAWrPANG..........VVAGSTAG...AMYPTPpdgvQQIGAAAF
  484-  534 (45.11/24.92)	DAA...........qmqSPSGQL.PSNNiagvgdqatqVTAGQAQGqasALAPAP....AAVTEPAF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.29|      41|     673|     631|     682|       8
---------------------------------------------------------------------------
  587-  631 (66.49/38.63)	QPAV.QDNSQ..NQGGMEGVQMTPSQEEQGASSKPLPPVFaARPdlrP
  640-  686 (61.80/32.10)	QQALqQSNTEnfNRNSAIGIKRHPSPFNPETVFKRICPAF.SRPppvP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.28|      20|      27|    1212|    1237|      12
---------------------------------------------------------------------------
 1212- 1233 (33.45/33.73)	RAIDFK.LAATPSPNllR.ENQCI
 1239- 1260 (25.83/ 8.88)	RSIDERwVTAAWTDN..RgSNQAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.80|      15|      27|    1309|    1324|      14
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 1309- 1324 (21.93/17.37)	DPhEIELWAARAQAET
 1338- 1352 (26.87/15.67)	DP.SLQLIPPAATIPT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27633 with Med13 domain of Kingdom Fungi
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