Description | Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MTNSQNIKNVITDLYTVLSLAANYDTISPSTVSTRNNAHHSTREALIHDFDLLAESLRETHRTASSTPLSASQGIPEPLIQYVENGRNPDIYTREFVELVRRMNQLMRGKMHAFGEFRDLLAREMTVALPELKEDVKKVVVETGGRWPLPEEEGEGMRGRRGSNRERERERERERERERERVG |
Length | 183 |
Position | Middle |
Organism | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.873 |
Instability index | 38.07 |
Isoelectric point | 6.25 |
Molecular weight | 21132.43 |
Publications | PubMed=21784248 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP27628 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 56.52| 16| 32| 33| 48| 1 --------------------------------------------------------------------------- 33- 48 (28.39/16.85) STRNNAHHSTREALIH 66- 81 (28.14/16.65) STPLSASQGIPEPLIQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GMRGRRGSNRERERERERERERERERVG 2) PLPEE | 156 148 | 183 152 |
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