Description | Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MTDRPFILQVPPTQQRGPQNIAEFVARINPDAFRVLNEAELRRKVEEEKNGVGQDEDVDMESSPSDNEGEPADAKDIITAKHEMLRVIDQTRQTTLYALDFVSLLLSKENPGQAVTTFSPGLRELVGIGTLGATMLDAPTPLTQSRIPDNKLVTIGKRLMDLNKAADTALAASKRLQKEIAAETKYWSEVLAVRNDGWQTSRMPREPQTMGVKFGFNNAAPEFKAVSIAPMRRADNGSVLLDRSSIGHKSQRIQVRILEDGRIVGRSSLPSPVSADAPLQDRVKEMRDTIFAQELWHEINREARTLLNQGVHLEPSSITYTMDASTTVSIRLATLGEEEEGLDEQQEGPQDVMAESLNIALSLLLSHAHRMNELRRSEPGINKGPPRTYPILLPLISYHKYNQSIQTCLQTLSAHISVLRSASVDSSMTVKEPLLSSPPGAPAATSLYTILTRPPAVQFDITITPDSRIRILLKPTQLTGAAFSICCLPALHPGAQNPLATTCPPSTDDYDSLTQVVSYLQAAIPRALAAHYEAVLVVEATVNGGMLGDLPPSPSRWMPLIDGKGIVDPETMRFGIRFSFGRNPAKGGQLELGAQTDYVDGSRKRVRRNWIWPGAQSSLDSVAKHVLARGPPEE |
Length | 634 |
Position | Head |
Organism | Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.336 |
Instability index | 55.64 |
Isoelectric point | 5.89 |
Molecular weight | 69537.27 |
Publications | PubMed=21784248 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP27625 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 87.80| 28| 330| 14| 43| 1 --------------------------------------------------------------------------- 14- 43 (45.46/37.39) QQRGPQNIaeFVARINPDAFRVLNEA....ELRR 345- 376 (42.34/28.16) QQEGPQDV..MAESLNIALSLLLSHAhrmnELRR --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 199.30| 61| 410| 125| 186| 2 --------------------------------------------------------------------------- 125- 186 (94.45/68.08) LVGIGTLGATMLDAPTPLTQSRIP..DNKLVtIGKRLMDLNKAADTALAASKRLQKEIAAETKY 536- 598 (104.85/71.35) LVVEATVNGGMLGDLPPSPSRWMPliDGKGI.VDPETMRFGIRFSFGRNPAKGGQLELGAQTDY --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 98.94| 31| 118| 379| 415| 3 --------------------------------------------------------------------------- 379- 415 (52.56/38.05) PGINKGPPRT..YPILLPLISYhkynqsIQTCL.QTLSAH 498- 531 (46.38/22.78) PLATTCPPSTddYDSLTQVVSY......LQAAIpRALAAH --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) MTDRPFI 2) NWIWP | 1 609 | 7 613 |
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