<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP27624

Description Uncharacterized protein
SequenceMTSRPPLGVQQPRPPQHQHTHKLPTSSLSQRSAPHQHQHQHQHYLQHQQQRVLAQQPPPQQPLPHQALQQHAYPLQQHAHFPPQSQSPVRRDVNGYDLTTTPDFGDGAAAMPSRQTLHRRPGSRLKLEIYNSDPADPTAASTILHDTSLTESPSCVADSKPFTPSRIMPPMDPSEMGDMSPDPSTHMHTADLDAPLPMPARPARINTVLPQRPAAQPPAASNTTSKKDSRPKPFTVEPPAAAPSYPVRGNDQQKTTVAYADFFPWTGNGPEDQFSEHVIRNGYYDKGIFSTAETQSAKATLFPALKHKTGLTALSSVFAAVLGQRRHNGQITTPSTFKPPPRVTLTDTKRELWLKDLANPAISLRRLSRTIPHGIRGKVLLEQCLNKNVPTDRAVWLIKCVGANEIRATKRKGVGTLVVGGESRWIKDWTISVEQFIEQVYFGFDEDDWKAKVHYTTRLAAHLYAEHLLDREHYSEWLVSSLENSSEARLPMWMLLTQLYWSDLLKLRKYGRRLVTALISHHHLIYNHPDRDILNPLLKTLTDCLNTLILSSPENFVCPAAWIKYRDALQACLPAGDEARRNSFEAINLRNEQLAASANRSQPAARHILVGMLDGTLHAPMPSDLPSQCWSVSQDKPALARALLEWCTSLYRPGLAKVYVTSKILQHWSTLGFDVTLAVLDFLCDDPLEEQPRKNALYHLVCELVRASLFAVSRYIRWLMGRGGVRRPEQVAPDGPAATRLLAEMPPCVLTSSERNLRSGILRRASYSVADEAENTVVAIKHLRYTFGMPMPDVQPNDPIFQRPPMAMAKLTKRISKASRTLKGEVGSWLRASLASSSSSSSSSSSSFSSSTGDKEKGGPQLPDVSPSVFYGMRSVLEAAEDFTILADVLKTLTKHCTVDILPAIADTVNRHFFIFSALDAASPIFLALHQRFKTTAVREQGITLRPLLVSLVSLGARIPGMEDVVARLKKDLALTDRHNPVDACSPVSDNMVSRLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQDDASDLHDEIEKLLAGGSSLDRNTMERLFQTIVQRLQAAWGGAAATKQRAYSTLLGRLRAFDAQCFDGLMVKWLMYLRALGSRPSVLRIFPLLVSVGCLEFGTILATASEFPTAGAGQQRVPVPPPATLAGGVPQVVQITYRTRYMQQVLMLLTAPVPQDDLLTADEAYRFLVLQDQAVRDSPKEVLNLIFLALAEYSYARAQNDLEGLPLDADYVQELLFELLKRLVLRDATGVARALSVRSTNPQVMARIDWMTTKLLIPTAAAPQTTRVSFEQVLELTNEFTLPFCQVKLALALSLSNNNNNNNNNTTTTTTGEDGQEQQTSHVELLANAMDKAIAAGNVAWVGMLSSLSPDITQHLKARAQSRFLELLPSPPGKATGSSGRVAADQASLEQNLRMAENLLSVMDAIMRGGSNATSPIPPGGSPRQAQLSPAVVDKLVDLWEILASPTSQPQDTKSEDTPMGNTPTVGVDPETKASLLLYHLPLLLNLLTLHNNTQSSLDFSRQPADLRAKLLIACAGILHLLDHAVDLFELSRPPGPDNSASSSTGVIHPLPAEGELPAELAFPHPAQHGTVGGHDQGQDRQEKHTALARAVANLSRRVFDLACLLADNLPEEARLTCVRAVGSGGVLALDGRLRYVLSVPWGVGFDVGVAGLQSGGQQQGQGDGAGSVFTAGGSGGGGMGIGFGGSGGGLVLCHRDSGGAKPSSSASAPPGTRNPTINNNTNPNSHSHSHSNSNSNSNSNISGTGTGTGSMCVLLGTPISLWGLDRPGGAATERFSVFHFRRWEALSEPTPVVGENDTALSLGLFEARKV
Length1875
PositionKinase
OrganismChaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Chaetomiaceae> Chaetomium.
Aromaticity0.06
Grand average of hydropathy-0.382
Instability index57.25
Isoelectric point8.10
Molecular weight205389.99
Publications
PubMed=21784248

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP27624
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     148.00|      17|      17|     997|    1013|       1
---------------------------------------------------------------------------
   46-   62 (30.25/10.08)	QHQQQRVLAQQPPPQQP
  997- 1013 (39.25/15.02)	QQQQQQQQQQQQQQQQQ
 1016- 1032 (39.25/15.02)	QQQQQQQQQQQQQQQQQ
 1033- 1049 (39.25/15.02)	QQQQQQQQQQQQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     208.15|      43|      43|     136|     178|       2
---------------------------------------------------------------------------
   83-  131 (51.26/23.44)	.PQSQSPVRRDVNgydLTTTPD......FGDGAAAMPSRQTLH.RRPGsrlklEIYN
  136-  178 (76.98/39.13)	DPTAASTILHDTS...LTESPS.....CVADSKPFTPSRIMPP.MDPS.....EMGD
  182-  200 (33.60/12.67)	DP...STHMHTAD...LD..................A.........PL.....PMPA
  201-  244 (46.30/20.42)	RPARINTVLPQRP...AAQPPAasnttSKKDSRP.KPFTVEPPaAAPS.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.19|      13|      17|      10|      22|       3
---------------------------------------------------------------------------
   10-   22 (28.91/13.58)	QQPRPPQHQHTHK
   30-   42 (27.36/12.44)	QRSAPHQHQHQHQ
   69-   80 (19.92/ 6.94)	QQHAYPLQQHAH.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.90|      15|      17|    1713|    1729|       4
---------------------------------------------------------------------------
 1715- 1729 (27.33/18.17)	AGLQSGGQQQGQGDG
 1731- 1745 (27.57/10.98)	GSVFTAGGSGGGGMG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.65|      15|      17|     372|     388|       6
---------------------------------------------------------------------------
  372-  388 (19.83/20.24)	PHGiRGkVLLEQCLNKN
  390-  404 (28.83/17.63)	PTD.RA.VWLIKCVGAN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.35|      16|      17|     302|     318|       7
---------------------------------------------------------------------------
  302-  318 (22.49/16.48)	FPALKHKTGLTAlSSVF
  322-  337 (28.86/16.86)	LGQRRHNGQITT.PSTF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.52|      16|      17|    1674|    1689|       8
---------------------------------------------------------------------------
 1674- 1689 (28.10/15.93)	LPEEARLTCVRAVGSG
 1692- 1707 (29.41/17.02)	LALDGRLRYVLSVPWG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.58|      12|      17|     885|     896|      10
---------------------------------------------------------------------------
  885-  896 (19.03/13.60)	ILADVLKTLTKH
  901-  912 (20.56/15.43)	ILPAIADTVNRH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.23|      41|      43|     709|     749|      12
---------------------------------------------------------------------------
  687-  715 (36.27/14.26)	............PLEEQPRKNALYHLVCELVRASLFAVSRY
  716-  756 (73.71/36.16)	IRWLMGRGGVRRPEQVAPDGPAATRLLAEMPPCVLTSSERN
  780-  805 (40.25/16.59)	IKHLRYTFGMPMPD.VQPNDPIFQR.....PP.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      60.99|      16|      36|     459|     474|      14
---------------------------------------------------------------------------
  455-  473 (22.97/14.14)	Y.................ttrLAAHLYAEHLLDREH
  474-  509 (14.76/ 6.01)	YsewlvsslenssearlpmwmLLTQLYWSDLLKLRK
  510-  528 (23.26/14.44)	Y.................grrLVTALISHHHLIYNH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     336.03|      85|      86|    1495|    1579|      15
---------------------------------------------------------------------------
 1430- 1493 (74.90/34.38)	.............ELLPSPPGK.........ATGSSGRVAAD...QAS.LEQNLRMAENLLSVMDAImrGGSNA....TSPIPpggSPRQAQL....S
 1495- 1579 (142.55/72.45)	AV...VDKLVDLWEILASPTSQPQDTKSEDTPMGNTPTVGVDPETKASLLLYHLPLLLNLLTLHNNT..QSSLD....FSRQP...ADLRAKLL.IAC
 1581- 1668 (118.57/58.95)	GIlhlLDHAVDLFE.LSRPPG.PDNSASSST..GVIHPLPAEGELPAELAFPH.PAQHGTVGGHDQG..QDRQEkhtaLARAV...ANLSRRVFdLAC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.22|      18|      21|    1077|    1097|      16
---------------------------------------------------------------------------
 1077- 1097 (25.71/20.58)	GSSldrNTMERLFQTIVQRLQ
 1102- 1119 (29.51/15.45)	GAA...ATKQRAYSTLLGRLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.46|      14|      19|     643|     656|      17
---------------------------------------------------------------------------
  647-  668 (20.76/12.09)	CTSLYRPGLAkvyvtskiLQHW
  669-  682 (21.70/13.04)	STLGFDVTLA........VLDF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP27624 with Med12 domain of Kingdom Fungi
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